#7

let me check if blood test is available for IGF1R & Sirolimus test in india and will add selenium to my supplement stack
Thanks

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#8

You ought to check your Selenium level first - sure, too little impacts ability to absorb nutrients, but too much can be toxic.
Selenium levels are highly variable across the whole population - you might find you are perfectly ok with your level.

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#9

good point will add selenium to blood test list

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#10

I have high normal testosterone yet I don’t grow a ton of muscle very quickly or have any clinical symptoms that would suggest too much or too little. High-normal serum doesn’t necessarily equal abnormal.

Check with your endocrinologist.

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#11

FWIW, have you tested your insulin levels? High IGF1 can be associated with diabetes/insulin resistance/metabolic disorders. What is your A1C? I used to have high IGF-1 and high inflammation. What helped me was going low carb and intermittent fasting.

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#12

Here is the effect on IGF1 and Sirolimus blood levels with LEF blood tests that I saw from 15mg Rapamycin every other week:

  1. Feb 17 (2 weeks after my last dose of Rapamycin and 12 hours fast) : IGF1 = 167 ng/ml, Sirolimus < 0.5 ng/ml. Fasting Insulin was 4.5uIU/ml, and A1C was 5.6. I am Type II diabetic, but take Metformin 2x500mg/day + Mounjaro 5mg/week.

  2. Feb 20 (2 hours after 15mg Rapamycin & 12 hours fast, no GFJ or other supplements known to improve absorption of Rapamycin within 24 hours) : IGF1 = 146 ng/ml, Sirolimus = 13.9 ng/ml

Others have reported peak Sirolimus blood levels scaling roughly 1ng/ml per 1mg of Rapamycin without GFJ or other absorption aids. In my case the Rapamycin is the Rapacan brand ordered from India from dropshipmd.com.

I am not sure what the typical drop in IGF1 is supposed to be or if the effect on IGF1 is maximum when Sirolimus blood level peaks (typically 1-2 hours after intake) or takes more time to fully kick in.

Update : Mar 3 (2 hours after 18mg Rapamycin & 12 hours fast, no GFJ or other supplements known to improve absorption of Rapamycing within 24 hours) : IGF1 = 126 ng/ml, Sirolimus = 49.5 ng/ml. Not sure why my Sirolimus numbers are so much higher than on Feb 20.

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Growth Hormone and longevity
Evidence that mTORC2 inhibition is detrimental, by Dudley Lamming
#13

Wonder if further reduction of A1C will help lower IGF1. Metformin has shown to reduce IGF1 and you have room to the upper limit of 2,000mg. Can’t tell your body fat percentage, but there seems to be a correlation. Long water fasting and Keto helped me drop initial weight. 2,000mg of metformin helped me drop the final pounds (I’m prediabetic). Sorry, but I have not repeated my IGF1 test for over 5 years.

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#14

Study of almost 400,000 confirms that higher blood levels of IGF-1 are a risk factor for several types of cancer

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#15

I am speaking off the cuff here without doing any research, but doesn’t IGF-1 activate/increase Mtor, not the other way around? So decreasing the downstream target of IGF-1,MTOR, may not have any effect on reducing IGf-1…. from my experience male hormones increase IGF-I, ie testosterone and DHEA, GH increases it greatly, and carbs increase it, with protein and food also having a slight effect. I don’t feel like having an all protein diet increases it crazily like some of these people say. I actually have low IGF-I levels myself naturally, like 70-ish, And taking 15-25 mg of the DHEA seems to raise it over 100… I personally don’t feel as good when my IGF-I is that low, it’s hard to explain…

Obviously, having raised levels is not good either. I don’t think around 150 like the person above is horrible, from my recollection those studies involve a level over 200, maybe even 300…

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#16

Sorry, didn’t mean to hijack this thread : I am not the one with the high IGF-1 of 293, I just posted my numbers after taking Rapa, to show that it does have a small immediate lowering effect.

I recently learned that the the Labcorp IGF1 blood test can be inaccurate if supplementing with Biotin (Vitamin B7), which is present in most multivitamins and Vitamin B formulations : These need to be discontinued 72 hours before blood draw to get an accurate IGF1 value. I saw this warning at marekdiagnostics.com, the site recommended in another thread for the lowest cost $59 (Labcorp) blood test for Sirolimus. This also affects most Labcorp hormone tests (eg T3,T4, Testosterone, Estradiol, FSH, LH, SHBG) except for the more expensive high sensitivity versions based on LC-MS technology.

Do NOT discontinue Biotin if it has been prescribed by a doctor. Some cancer drugs (also Metotraxate used for Arthritis) require large doses of Biotin to minimize damage to non-cancer cells, and discontinuing Biotin can be dangerous.

You can get an LC-MS version of IGF1, that is NOT sensitive to Biotin, from Quest Labs (Ultralabtests.com offers it for $69 + $8 blood draw fee). The regular Labcorp version that is sensitive to Biotin is $75 from LEF or $39 + $5 from marekdiagnostics.com.

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Discount Code for Lab Testing
#17

Have you tried reducing your protein intake?

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#18

I recently had a high IGF1 level and my hypothesis is that it’s caused by regular training and 10mg melatonin at night;

#19

How high was the level?

#20

Little known fact. Testosterone therapy and increased estradiol conversion from it can show increased IGF1

#21

According to the study, IGF-1 remained unchanged?

#22

My levels increased from 260 to 360, I never had these kind of levels, so I will retest. My estradiol was increased 20% from HCG 500 IE weekly I added to my TRT. For the rest, I didn’t change anything in my routine.

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#23

I got the idea that “higher dose” melatonin supplementation causes higher IGF1 from the Youtube performance coach Vigorous Steve . This is the only study I could find who could explain the mechanism behind it.

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#24

20% higher estradiol would more than likely raise IGF1 level, so that’s the likely explanation. What was your exact estradiol level?

As far as I know, high IGF1 appears to be worse if it’s naturally high with no explanation.

If you incorporate things that raise it, like HCG in this case, I don’t think it’s as much of a problem.

For instance, there has never been any causal link between HGH and cancer, despite HGH raising IGF1.

There are also no links to cancer for testosterone therapy, despite the fact it could drive IGF1 up a bit from the increased estradiol.

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#25

Thanks for the reply, estradiol before was 39ng/l, it raised to 51. I am not worried about the high IGF1, but I want to determine the cause.

#26

I think that’s the probable cause. IGF1 was lower when estradiol was 39 and higher at 51, correct? That aligns with a lot of people’s experiences. When estradiol is higher, IGF1 is higher.

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