#26

Good question. Its mostly more just my impression and interpretation of what Marco Quarta was saying in his presentation about the new world of “Senolytics 2.0” and the implications of what he was saying. James Kirkland was not there, and nobody at the conference was discussing dasatinib and fisetin. But that is what seems to be the implication of all this new research being reported on. But - yes, don’t take my word as gospel. If I was planning to take dasatinib / fisetin, etc. I’d first talk to some of these researchers to see what the current thinking is around these interventions. It seems like the pendulum is swinging in a very different direction now.

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#27

I have been using it for the last 2 months in combination with Rapamycin cream and Tretinoin. Very hard to comment on the efficacy. The science base is interesting, but the aggressive marketing approach makes you wonder. It is obviously driven by commercial objectives.

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#28

Yes - its always hard to know where the science leaves off, and the marketing begins. Ultimately you have to make the call to continue buying or not based on your own results.

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#29

So what dosing of Rapamycin was trending? 6-9 mg weekly?

#30

I didn’t get into dosing with enough people to get a read on that with any accuracy.

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#31

Could organ-targeted senolytics then be chosen, based on which organs are aging the fastest ?

My apologies if I haven’t linked my post appropriately

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#32

Thank you Rap Admin. For the past few years, I keep approaching the starting line of Dasatinib and Fisetin but each time, I back off given I’m not convinced of the safety profile. I was approaching the starting line again and then read your post here. So backing off again. HA! Appreciate the reply.

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#33

What is the safety profile issue with Fisetin?

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#34

I’ve not heard anything regarding safety issues with Fiseten. I think the bigger issue would likely be the cancer drug dasatinib.

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#35

Hi RapAdmin,
Do you have a link to the “latest SGLT2 inhibitor review article”?
Thank you.

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#36

1-s2.0-S0033062023001068-main.pdf (1.9 MB)
https://www.sciencedirect.com/science/article/pii/S0033062023001068?via%3Dihub

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#37

@DrG was nice enough to post it. But we also have links to all the latest good papers on canagliflozin and other SGLT2 inhibitors in this thread: Canagliflozina – Outro medicamento antienvelhecimento de destaque

#38

I’ve thought about this a fair bit. I don’t think this will ever be financially viable or practical. Growing a body and keeping it in optimal health is a massive energy expenditure. You’d essentially need to double food production. Also our bodies are shaped by our environment, it may be possible to stimulate muscles and replicate exercise to keep the body in perfect health but it seems like an incredible amount of resources. Even if you were to say grow a body and do the transplant at the earliest possible window, which is probably around late adolescence. I think it’s more likely we’ll find a way to grow specific organs for transplant, but then even that probably requires an organ of a certain maturity for it to function well enough. It’s super interesting.

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#39

Using what product? Please explain!

#40

He’s talking about the OneSkin product. See the presentation above.

#41

I found the website where they sell it. See here:

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#42

I’ve been using their face cream, eye cream, and body lotion for several months now. I love them! I receive positive comments on my skin. I use to use rapamycin cream, but it made me break out with acne. I’d love to try it again at some point, but OneSkin has been a great alternative. I think their products work. I’m going to continue to use them.

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#43

I’ve been using OneSkin on my hands and face (the eye cream, face cream and body lotion) for perhaps three months now. I like the products, and I’m going to continue with them, but I must mention that so far, I haven’t noticed any dramatic changes. I actually went so far as to do a couple “before” photos in my bathroom (which none of you will ever see, since I took them without a speck of makeup on, in a very bright, harsh light–not flattering!), and I compared them to new photos, taken in the same conditions, about a week ago. Well…I’m not looking any worse (haha), but I can’t say that I’m seeing any improvement, either. I believe the company says it’ll take several months to see noteworthy changes, so I’ll let you know what I think in another month or two.

I do want to say that I’ve been reading up on them for quite some time, and I was also in attendance at the longevity summit that our beloved RapAdmin so thoroughly reported on (Thanks, RapAdmin!), and I believe their research is legit.

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#44

Several days ago, I also took some before pictures around my eyes. I’ll apply only OneSkin around one eye and my usual rapamycin cream around the other. I hope to see a difference in a few months.

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#45

Canagliflozin is getting all of the headlines. Maybe because Ivokana Canagliflozin is not available as a generic in the U.S.
Empagliflozin is a generic and might be the better choice for both efficacy and cost.
Empaglifozin is available from India at about a 33% cheaper price than Canaglifozin.

"We found similar reductions in worsening HF with empagliflozin, canagliflozin and dapagliflozin. However, empagliflozin was associated with a greater reduction in all-cause and cardiovascular mortality.

“Comparative efficacy of sodium-glucose cotransporter-2 inhibitors (SGLT2i) for cardiovascular outcomes in type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials”

https://sci-hub.se/10.1007/s10741-020-09954-8

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