β-hydroxybutyrate is interesting because in ketosis it can be around at a millimolar level which has significant HDAC inhibitory effects (or perhaps more precisely KDAC). I have not myself seen the same argument made for acetoacetate or acetone.
Q re acetone
Q more generally
Interestingly acetoacetate appears to be a weaker KDAC inhibitor (If anyone is interested in this the second chatGPT is worth reading).
Acetate itself has interesting functions, but operates homeostasis within the cell which means it is not that good as an exogenous intervention (unlike citrate)
1 Like
Within the context of this KE4 is potentially an interesting supplement or any other ketone ester that produces beta hb.
