#122

May I ask your dosing? I have a 6 pound papillon. Dr Kevin has him on .5 mg once per week. I have not found that size from any of the Indian sites. I heard other dogs get their Rapa 3x per week.

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#123

Heā€™s 13.5 pounds and gets 1mg/week.

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#124

Everolimus (another version of mTOR inhibitor, very similar to rapamycin) is available in smaller dosing quantities - see the photo below. More information here: Everolimus instead of Sirolimus / Rapamycin? Anyone else trying?. (82 rupees to the US$, so divide the prices below by 82 to get US dollars.)

Screen Shot 2023-12-09 at 10.58.35 AM
Screen Shot 2023-12-09 at 10.58.35 AM1038Ɨ618 33.6 KB

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#125

Thanks I have considered that but it is not as potent. Is it close enough to be safe for dogs?

#126

Itā€™s listed under company SS Enterprises on Indiamart. On Indiamart, it will be referenced as Sirolimus rather than rapamycin.

Edit: Removed second source. They apparently no longer have it. It is still listed under SS Enterprises above.

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#127

Thanks you just saved me a fortune!

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#128

Yes, thank you @Vlasko! Iā€™ve been wanting to have him on 0.5mg more frequently.

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#129

Seems like minor differences to me but here is a paper looking at gastrointestinal pH in Dogs and humans. Dog stomach pH is slightly higher (more basic) and Dog intestinal pH is also slightly higher (more basic). This suggests to me that if anything sirolimus would be more stable in the dog gi track resulting in better bio availability.

https://doi.org/10.1002/jps.2600750313

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#130

Let me know how more frequent dosing works.

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#131

@Pattyg Will do! Iā€™d prefer the 0.5mg for myself as well tbh. I have quite a bit of the 1mg on hand right now so Iā€™m probably a few months away from reordering.

#132

Does anyone know if Zydus manufactures sirolimus in 0.5 mg?

India Mart has several vendors that listed, but all reply that they only have 1 mg and 2 mg.

#133

Unfortunately it seems the Indiamart vendors who were providing 0.5 mg pills no longer offer them.

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#134

If you have a small dog, and are looking for sub-1mg dose tablets, Iā€™d look at Everolimus. There are vendors, including Zydus, that provide 1mg and sub-mg tablets in that form: Everolimus instead of Sirolimus / Rapamycin? Anyone else trying?

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#135

Thank you. Will do a deep dive on Everolimus. One Indian pharma respondent suggested the 1mg sirolimus be split with no comments on bioavailability :roll_eyes:. Triumvet is using a patented coating. Sounds like there may be evidence of higher oral availability of everolimus. Lots of questions about equivalent dosing.

#136

I think I could get more comfortable with Everolimus if there was/were:
ā€“ more clarity regarding MTorc2 inhibition
ā€“ available reports on purity
ā€“ more clarity on oral bioavailability and dosing

RapAdmin, did you ever decide to incorporate everolimus into your regimen?

With all of these outstanding questions, Iā€™d prefer to stay closer to the TRIAD study standards, but am interested to know if anyone else is dosing their dog with everolimus.

For now, splitting a Zydus or Biocon 1mg tablet and placing into AminalBiomeā€™s #4 delayed released capsule seems to be a reasonable option.

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#137

I probably have the weirdest story about dog dosing. Weā€™re both pretty new at this - two months or so. My first prescription was supposed to be 5mg doses, my own recco to my MD with which he agreed, but the compounding pharmacy screwed up and sent me 12 x 100mg (!) capsules. I talked to my doc and we agreed on 5mg, and asked them to exchange. They said they had no use for the first batch, sent me a refund (Godawful expensive, it was), said to keep the others, and sent 12 x 5mg caps. I was aware of both Matt K.'s dosing and Dr. Kevinā€™s, and I thought Dr. Kevin might be a bit much with 3X weekly. I used a precision scale to weigh the capsule and contents of a 100mg cap, thinking that if I could divide it into 20 doses Iā€™d have 5mg each to give him. BUT there was not enough mass/content in each to divide into 20 doses. So, he is getting an inexact and possibly excessive dose once weekly. I know what it weighs, and know it is about 1/5 of the contents of a 100mg - but no idea how strong it is. So, weā€™re on week five or so, with no bad symptoms, but no great changes either. Heā€™s a big healthy ten-year-old, and is still big and healthy. Me, Iā€™m taking the 5mg/wk and feeling good but nothing standing out - yet. Iā€™m 75, ex-bike racer, bodybuilder, active pilot - some orthopedic issues from trashing myself, but still working out moderately and in excellent shape and weight . Both of us use lots of life-extension type supplements, and have for years. Great to be in your company - this is fun!

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#138

Hi, Iā€™d be most concerned about 2 major issues. 1) the quality of the compounding pharmacy. Giving you 100mg capsules is a MAJOR screw up. That could have killed you and/or your dog. How much can you trust that they actually know what they are doing? 2) how much of the compounded capsulized rapa is being absorbed? See other extensive discussions on the forum regarding poor absorption from compounded rapamycin capsules as opposed to tablets

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#139

Yes - there are frequently problems with the compounding pharmacy rapamycin. See these threads:

Here: Bioavailability of Rapamycin From Compounding Pharmacy

Here: Compound pharmacy rapamycin capsules - bioavailability, concerns, & solutions?

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#140

Please support the continuation of the Dog Aging project by signing the below petition for Matt Kaeberlein. The NIH is likely not renewing its funding at one of the most critical points in the study.

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#141

Hi there, Iā€™m a long-time lurker and just started myself and 3 pups on rapamycin. I havenā€™t seen anyone post this study yet from last year A masked, placebo-controlled, randomized clinical trial evaluating safety and the effect on cardiac function of low-dose rapamycin in 17 healthy client-owned dogs - PMC. Itā€™s Matt Kaeberleinā€™s 2nd trial on rapamycin in dogs. Iā€™m no expert, but as far as I can tell there was no statistically significant difference between the groups in the clinical evaluation; however in the owner questionnaire in response to the question, ā€œHas your dog experienced any positive changes in behavior or other things that you would associate with good health within the past week?" owners of dogs in the rapamycin group replied with a ā€œyesā€ response in 26.8% of all surveys while owners of dogs in the placebo group replied with a ā€œyesā€ response in 8.1% of all surveys. This trialā€™s rapamycin treatment group received 0.025 mg/kg three times weekly for 6 months.

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