#114

I’m 62 and my skin is beautiful … no sagging yet!

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#115

Tell us more about growing probiotics and the results you have. Do they take away fine lines or lighten skin?

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#116

I assume you micro needle and then spread the tret/rapa mix onto your freshly needled face?

#117

No, I mix the rapamycin into the Ret-A, then liberally spread it on my face, chest, hands and forearms. Then I use a small microneedle roller and roll it into my skin … please recall I said I’m a maniac. The first time it did it … it caused a lot of red raised skin. By the third time my skin was not so irritated. I’ve been doing it weekly … though I think I’m going to go to bi-weekly.

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#118

The probiotics are very soothing. My skin is already pretty good so its hard to tell if it is doing more. As for lightening … I’m a redhead and my skin is very fair and I don’t have age spots on my face so I have not been focused on lighten…

#119

Hormones may be leveraged to treat and prevent signs of aging such as wrinkles and hair graying, according to a study, “Endocrine Controls of Skin Aging,” published in Endocrine Reviews .

Until now, only a limited number of hormones, mainly topical retinoids (retinol and tretinoin) and estrogen, which are typically used to treat side effects of menopause, have been used in clinical practice as anti-skin aging compounds. This study reviews a new class of hormones and their anti-aging properties.

Melatonin is especially interesting as a potential anti-skin aging substance as it is a small molecule, inexpensive, well-tolerated and a direct and indirect antioxidant as well as a regulator of mitochondrial metabolism. Some of the studied hormones, moreover, have astonishing and unexpected biological effects on skin function and hair aging, as highlighted by distinct genetic deficiency syndromes.

They also reviewed the emerging roles of additional endocrine players, including α-melanocyte-stimulating hormone (responsible for skin pigmentation), members of the hypothalamic-pituitary-thyroid axis, oxytocin, endocannabinoids (found in CBD products) and peroxisome proliferator-activated receptor modulators and found they have very promising effects, e.g. on UV-induced genotoxic stress crucially involved in the development of photoaging and pigment synthesis within skin and hair.

Paywalled Source Paper:

Markus Böhm et al, Endocrine Controls of Skin Aging, Endocrine Reviews (2025). DOI: 10.1210/endrev/bnae034 , dx.doi.org/10.1210/endrev/bnae034

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#120

Finally some reasonably priced topical rapamycin with added bonus - exosomes. I don’t know of any good studies on the latter but the got the cream just for rapa alone.

https://www.musely.com/cellrepairserum

  • iPSC Exosomes 250 million/bottle
  • Rapamycin 0.0125%
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#121

Melatonin is especially interesting as a potential anti-skin aging substance as it is a small molecule, inexpensive, well-tolerated and a direct and indirect antioxidant as well as a regulator of mitochondrial metabolism.

Makes me wonder if one could usefully (and safely) apply melatonin topically; if the molecule is small enough, with a bit of transcutol, well… that would be easy to mix up.

I myself can’t tolerate melatonin orally, except at teensy doses, but topical applications are generally thought to have localized effects. Hmm.

Anyone tried this? Any theories?

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#122

I’m interested too and have some transcutol and powdered melatonin on hand. Thanks for asking. If I find anything useful I’ll put it in this thread.

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#123

Per Copilot:

There are several skin penetration enhancers that can be used to improve the absorption of powdered melatonin through the skin. Here are some commonly used options:

  1. Transcutol® (diethylene glycol monoethyl ether): Known for its excellent solubilizing properties and ability to enhance skin penetration
  2. Propylene Glycol: Widely used in topical formulations
  3. Ethanol: Often used in combination with other enhancers to improve skin absorption
  4. Oleic Acid: A fatty acid that can disrupt the skin barrier and enhance the penetration of active ingredients
  5. Dimethyl Sulfoxide (DMSO): A powerful penetration enhancer that can increase the absorption of various compounds through the skin
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#124

I’ll try it too and report the results if any.

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#125

Awesome. I just found this which is older from 2012 but still seems positive although I’m not a scientist.

“Regarding clinical application, exogenous melatonin should rather be used topically than orally, since orally administered melatonin appears in rather low levels in the blood due to prominent first-pass degradation in the liver, thus limiting skin access.84 Topical application might be meaningful, since melatonin can penetrate into the stratum corneum and build there a depot due to its distinct lipophilic chemical structure.85Therefore, endogenous intracutaneous melatonin production, together with topically applied exogenous melatonin or metabolites can be expected to represent one of the most potent antioxidative defense systems against UV-induced skin aging.25,29-31”

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#126

I definitely want a full report!

I have been using the Elevai serum with exosomes for about a year and my skin seems to love it, but this serum with the addition of rapa is quite appealing.

1 Like
#127

I have been using a 1% melatonin lotion on my scalp since 3 weeks without any negative reaction. (I upped the dose). I use a self made lotion with similar ingredients as Bryan Johnson, he uses 0,1% melatonin

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#128

Isn’t that a tiny amount? 1% and 0.5% rapamycin creams is used for facial angiofibromas,

1 Like
#129

Please tell us the type (genus, species, and strain if it’s a unique strain) of the probiotics you’ve been using. Thank you

#130

Just watched this interesting and informative video of Amitay Eshel, co-founder and CEO of Young Goose. I didn’t previously know some of the information, such as advantages of topical NR and NMN over NAD+ or niacinamide, for example, or that topical spermidine plus spermine and putrescine is more effective than just spermidine. Or that certain marine algae extracts were senolytic or senomorphic.

1 Like
#131
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#132

Well crap, I guess Ima ordering that now.

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#133

Has it occurred to you that this might just be BS? Topical niacinamide has a ton of evidence and clinical studies behind it. NR and NMN do not. And a quick google search shows that this guy sells… topical NR and NMN products… what are the chances!

7 Likes