#672

I’m not a fan of using DMSO (at least in high concentrations) as a skin penetration enhancer. See this commentary on DMSO and other penetration enhancers from a dermatology textbook: Rapamycin for Hair Growth and Hair Pigmentation - #320 by RapAdmin

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#673

Sorry I’m well behind the curve to respond to this, but there’s definitely some chatter about Fotona removing fay from below the facial skin and giving a worse (older) appearance. Probably a less-skilled operator, but still: a risk I’m personally not willing to take.

https://www.reddit.com/r/Fotona4d/s/nUFCI2KuBQ

(Yes, this is only one reddit thread and not a clinical trial with a appropriately powered double-blinded control group of sufficient size, but there appeared to be a lot of this type of chatter. )

#674

I’ve been using a serum containing vitamin C, vitamin E, and ferulic acid for a few years now. I started taking it a few years ago at the recommendation of my brother. That was before I really got interested in longevity, so I’ve never looked into the actual research on this combination, but subjectively I’ve always been impressed by the results.

I was actually surprised reading through this thread, where I only saw one mention of this combination—it’s also part of Bryan Johnson’s regimen.

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#675

I do the same with very good results. A more affordable copy of Skinceuticals Ferulic CE. Have no affiliation with either company.

[Ferulic Acid CE Serum | Skin Beauty Solutions]

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#676

I did use it for few years, but I hated the smell of it after few hours. It smelled like burnt skin. I also find that if you use tretinoin there was no added benefit I could observe just additional hassle of another product. I also think it made my skin more oily.

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#677

Ooh all of that is exciting! How did you find your polynucleotide results (or is it a bit early to tell still?) ?

I am concerned about it potentially being a waste of money if rapamycin reduces collagen synthesis. Unsure how to link to another post but Does rapamycin increase or decrease collagen I/II/III/IV/VII synthesis?

#678

I am not yet taking rapamycin either but plan to. But from your comment, the way i think about it is that i “pulse” have periods of planned autophagy (for me fasting, four consecutive days every 1.5 months or rapamycin 2x/month dosing) which reduces MTOR, and most of the rest of the time i can increase MTOR and collagen synthesis. So the fact that some things increase MTOR and some reduce it is all according to plan.

#679

The areas treated with polynucleotide were also treated with either one of the hyaluronic acid products, making it difficult to distinguish their individual effects. I was pleasantly surprised by the results around two weeks in, as I didn’t have high expectations initially. Some initial tightness I experienced has diminished, and I feel that the improvement is ongoing. I’m very pleased with the results. Just today, a friend commented that I looked good, even though I had only had 4 hours of sleep and an early morning flight. She specifically mentioned that my eyes looked youthful. This is where the most noticeable difference is apparent - the skin is tighter, laughter lines are less prominent, skin more elastic, and my brows appear lifted. The increased volume, maybe I should say plumpness in my brows and temples has made a significant difference. The skin under my eyes looks younger, with no visible signs of aging. The area with the least noticeable improvement is my chin, where I may consider fillers as there may also be some bone loss contributing to the issue. However, overall, I’m really happy with the results.

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#680

The interesting part is that most compounded prescriptions for topical Rapamycin are dosed daily.

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#681

This always confused me for skin rejuvenation. Virtually no-one recommends this for oral. Why would it be different? And why would you not require some “pulsed” MTOR stimulation to rebuild collagen/elastin?

#682

It may be based on this only human study I am aware of, where they used 0.001% rapamycin daily. Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial - PubMed

Which by the way is much lower than the 0.2 % or more typically sold online. For example gethealthspan sells 60 gm tube of 0.2 % or higher and one is supposed to use that over 90 days.

0.2% of 60 gm = 120 mg of rapamycin / 90 = 1.3 mg per day or 9 mg per week.
I know it’s topical and it’s supposedly poorly absorbed but it just seem like a big dose to use just on the face.

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#683

I noticed the word “paiva” and the word “polynucleotide” several times in this thread and I wanted more information. With a bit of research there seem to be some PubMed studies, but I also found this very current article in Harpers Bazaar. It’s very readable (maybe 10 minutes) and interesting. Apparently, injected polynucleotides can cause the skin to undergo some rejuvenation. I would like more information about safety and how long it lasts, but did not find that. How it would compare to laser treatment or retinoids would be nice, too, but I found nothing there.

#684

I was told the effect should last about a year. I had this done few weeks ago, did not research in depth, but the result is really natural, it is not a filler, skin appears plumper and younger looking. I would say it gets a better texture. The best I can describe it is similar to using instagram filter. It does not change you, but you appear somehow younger.

#685

4 posts were merged into an existing topic: So, what’s the deal with collagen?

#689

One interesting aspect of the genome is how the non-coding DNA acts as a form of metabolic logic and makes decisions for the cell without actually producing proteins.

Clearly this goes wrong in the same way as other aspects of transcription and that can affect other things. It could affect the way the cell deals with nutrient availability. I probably should read up on this at some point.

1 Like
#690

Would you know (off the top of your head — i don’t want you to be my librarian) if TOR not turning off when eating excess nutrition is just due to excess nutrition which leads to metabolic misbalances (high TG, high BG, etc) or does it happen when larger amounts of amino acids are provided (let’s say hydrolyzed plant-based amino acids so we don’t get potential/perceived “issues” with animal protein). Or perhaps TOR being on “excessively” may not be an issue when involved in recovery and muscle building? I ask because i see a number of older natural body builders and athletes (who haven’t destroyed themselves like football players) who look fantastic for their ages (obviously not a Clinical research trial or MR) — are they actually aging faster but the visual impact of muscles make them look younger?

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#691

Interesting the same red lights I have!

#692

So, in effect, you’re asking what nutrients or other factors are the primary activators of mTOR and what is their relative contribution to aging - would that be a correct characterization of your question.

I’ve not dove too deep into this but if you search on “mTOR activation” or “mTOR activators” in our forums we’ve had many conversations around different aspects of this topic. Dudley lamming (formerly of the Sabatini Lab) has research suggesting the iso-leucine is one of the major activators of mTOR, see this video (and thread): If Validated This is Huge News on Leucine -- A Paradox Solved? - #4 by AlexKChen

and this thread: Dudley Lamming Interview, a Leading MTOR & Rapamycin Researcher

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#693

Organic silicon may promote collagen production and improve nail and hair quality. I mix one teaspoon of the product below into my daily collagen peptide drink.

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#699

I use topical finasteride and it is producing some good results. My concern about taking finasteride is the side-effects. Has anyone had any side effects from taking finasteride?

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