I’ve read this entire thread a few times (although focus and reading comprehension may be an issue) and must confess I am confused a bit with one aspect of a Rapamycin based skin treatment. (I’m not doubting it is effective, but only in how to integrate it with other therapies). I am working on incorporating the terrific ideas here in this threat, with some “regrowth/rejuvenation” from GSK-Cu or other potential compounds, as well as hyarulonic acid. I am thinking of two different water/DMSO spray treatments daily: one in the morning (with Rapamycin) and one at night (with retinol-A), and similar for a @Agetron hair tonic but with some slightly different ingredients). But I am confused based on my (simplistic) assumptions of how the main ingredients will impact my hair/skin:
o. Rapamycin inhibits MTOR so should slow cellular aging by slowing cells from reacting to stimulus?
o. Retinol-A (or other potent vitamin A derivatives) stimulate “regrowth” (I assume through killing the already-near-death surface cells)?
o. There are other serums which promote cellular regrowth, to thicken skin and regain elasticity? Topical GSK-Cu in DMSO is the one I’ve selected but others are suggested as well.
o. There are hydrating elements such as hyarulonic acid which have good impact on adding moisture (and thus volume) to skin, as well as skin health. Won’t this clash with retinol-A impacts?
I’m thinking of two separate “serums”:
MORNING: Rapamycin in sparing DMSO and water, sprayed on skin (and hair with minoxidil).
NIGHT: retinol-A in sparing DMSO and water, sprayed on skin (and minoxidil for hair)
Where do I put the regrowth/rejuvenation compound (GSK-Cu)? Where do I put the hyarulonic acid? Do I need to use different serums in alternating weeks?
The most common protocol for oral Rapamycin seems to be a “pulsed” approach of weekly or every two weeks. Why are we administering topical Rapamycin daily on skin instead of “pulsed”? — won’t that negate some of the positive impacts of cellular regrowth? (This must mot be an issue because I see many of you are using this protocol with high effectiveness, and dr green and others have prescribed this to many patients for years and might have noticed if it wasn’t working)
I see some people using Retinol-A (etc) daily topically on their skin (perhaps nat might) and Rapamycin daily as well (perhaps in the morning). Don’t these two effectively cancel each other out? (I don’t think they do because some of you are using this protocol will high effectiveness)
If I want to incorporate a regrowth/rejuvenation element such as GSK-Cu into a topical treatment, won’t this negate the effects of Rapamycin (or vice versa)? Will I this need to pulse my treatments every few days/weekly to see benefits from both protocols? For that matter, won’t this clash with the Reitmo-A treatment as well?
If I want to incorporate a hydrating element such as hyarulonic acid into a topical treatment, wouldn’t this clash with the Retinol-A treatment and be better with the Rapamycin treatment?
I’d love to hear thoughts on this, and especially where I’ve erred. Thank you.