José
#1
What was the “low/lower,” assay reference?
Forum member John_Hemming, post he was getting an assy with the reference used was a lower number than the “normal / standard” reference used by the majority of labs.
I’m not sure if I’m answering your question - but HsCRP in the U.S. is:
<1.0 Optimal
<3.0 Normal
Over 100 call the mortician (not really … anything >10 I usually want a reason why, and will work up if we have an infectious or inflammatory or malignant issue ongoing)
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adssx
#3
Even 0.7 for women to be first quintiles? Cardiovascular Health - #1056 by adssx
Yes, the lower the better. But data for optimal is interesting - I tend to stick with what Quest/LabCorp list and they have been <3 is normal, <1 is optimal for health outcomes. Sure, great to be at 0.2 … just not sure that gets you much over being at 0.8 … maybe a little benefit.
Vera-Health.ai goes with Low Risk <1 mg/L, Average risk 1-3, High risk>3.
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The baseline indicates baseline Il-6 which is part of SASP see my chart in Exogenous intervention in mRNA transcription
José
#6
John,
What was the low reference for the lab you use/used for hs-CRP?
José
#7
FWIW…
“C Reactive Protein”
StatPearls…the same notes medical doctor and researcher use.
This article is probably worthy of a dedicated post … but I’m too lazy. Really interesting article on combo of CRP, LDL, and Lp(a) predicting outcomes with cardiovascular disease with 30 years of followup. It was exclusively on women, but we’d expect similar patterns with men (probably just stronger effect).
And the best way to reduce CRP is?
Mine is uncomfortable at 1.39. Not sure what I’m doing wrong though.
Vera-Health.ai did a pretty good job … here is their answer - similar to mine.
To decrease high-sensitivity C-reactive protein (hsCRP) levels, which is a marker of inflammation and associated with cardiovascular risk, several strategies can be employed:
Medications: Statins, primarily used for lowering cholesterol, have been shown to reduce hsCRP levels, providing an anti-inflammatory effect 1. Colchicine, an anti-inflammatory drug, has also demonstrated efficacy in reducing hsCRP in patients with coronary artery disease 71.
Lifestyle Changes: Regular physical activity, including both aerobic and resistance training, can decrease hsCRP levels and improve overall cardiovascular health 1. Additionally, improving sleep quality is crucial, as poor sleep has been linked to increased hsCRP levels 5.
Dietary Interventions: A diet rich in anti-inflammatory foods, such as polyphenol-rich foods, and low in ultra-processed foods can help reduce hsCRP levels 61. Weight-neutral dietary interventions specifically targeting inflammation have shown promise in reducing cardiovascular risk 6.
Nutritional Supplements: Vitamin D supplementation has been shown to lower hsCRP levels in individuals with type 2 diabetes and vitamin D deficiency 1. Propolis supplementation has also demonstrated potential in reducing hsCRP levels in women with polycystic ovary syndrome 1.
Gut Health: Modifying the gut microbiome through synbiotics (a combination of probiotics and prebiotics) can effectively reduce hsCRP levels by decreasing systemic inflammation 41.
Periodontal Health: Addressing periodontal disease can lower systemic inflammation. Non-surgical periodontal therapy has been found to decrease hsCRP levels in individuals with gum disease 11.
These strategies can effectively reduce hsCRP levels and potentially lower the risk of cardiovascular and other inflammation-related diseases. It is important for individuals to consult healthcare providers before making significant changes to their medical or lifestyle interventions.
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amuser
#11
So this is mostly a plot of range restriction, as the dominant oscillation just reflects minimum values (.3 and .15) at two different labs?
CRP is C Reactive protein.
hs means high sensitivity.
I have three different highest sensitivities in mg/L 0.15, 0.16 and 0.30
You can test for CRP with a test that is a lower sensitivity with a threshold of 0.6
According to Morgan Levine the original data for her formula had the threshold of 0.6 and is hence not as reliable with results below that.
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Yes, and if you read the text:
CRP is a protein produced by the liver from Interleukin-6. Interleukin-6 is a cytokine both produced when an infection occurs, but also as part of the Senescence Associated Secretory Phenotype (SASP). By taking weekly CRP tests it was possible to identify a background CRP level which when there is no infection indicates the burden of senescent cells. This was reduced during the citrate supplementation from 0.5 mg/L to under 0.15mg/L (which is the testing threshold of the most sensitive lab test. This implies an association of citrate supplementation with a reduction in senescence. (see chart).
In the chart it can be seen how an infection from time to time increases IL-6 and CRP, but then it goes back down to the “too low to measure” value.
It should be noted that 0.15mg/L is a very low value for CRP for an older human male.
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I think citrate supplementation is the best way. Possibly melatonin or rapamycin also helps.
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RobTuck
#16
For reducing the risk of a significant ASCVD event in adults >65, my personal judgment is that a target hsCRP of <0.5 based on the LabCorp protocol) is both desirable and attainable.
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Low dose colchicine is cheap, effective and FDA approved for reducing inflammation in CVD. I know people seem to be worried about its toxicity but that only appears to become dangerous at way higher doses. FWIW I’ve been taking 0.5mg daily for 18 months now without any issues, n of 1 obviously. You could easily split the pill into 2 or 4 while you gain confidence with it.
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Davin8r
#18
I wish we had data on whether or not colchicine helps if CRP is already low. It would seem like an obvious thing to measure before/after in any colchicine/CVD outcomes trial, but I’m assuming the Lodoco trial did NOT do this because the pharmaceutical company wanted the broadest possible indication (“it’s good for everyone/anyone at risk” which is good for drug sales) rather than to risk narrowing it down (“it only works for those with elevated CRP”). They’d rather us not know so that they can sell more drug.
Well maybe… but at 5c per tablet (from India) they’re welcome to my money.
Davin8r
#20
It’s not so much the cost (it’s only 30 bucks for 90 pills using manufacturer’s coupon for branded Lodoco if you have private health insurance in USA), but rather it’s taking an additional drug that has potential side effects, interactions with other medications, may in theory reduce muscle hypertrophy from resistance training, and so far has not shown a benefit for mortality.
