I think the main benefits of HBOT arise from HIF activation. I don’t think Hyperoxia has any benefits beyond that.

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The influence of CO2 on up regulation of hypoxia related genes.

“ Because nasal breathing prevents hyperventilation during exercise, it promotes an increase in the partial arterial pressure of CO2. The rise in systemic CO2 stimulates hypercapnia and permits the upregulation of hypoxia-related genes.”

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