#141

did you run it through an AI engine to get these #? If yes, what kind?

#142

Can you elaborate on the excitement on Dihydroberberin and Tributyrin? What was your baseline on ApoB and what interventions resulted the reduction?

#143

How long have you been on pantothenic acid and at what dosage that resulted the drop of apoB and ldl?

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#144

@Jonas Since Sept 8 2023. My last test results were Nov 10 2023. 500mg / day.

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#145

that’s interesting info! I would be interested to hear from those taking it if they are seeing benefits beyond juts muscle growth

#146

Why to change pantothenic acid ( that seems to work for you) for pantothine ?

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#147

Berberine has many of the same benefits as metformin, including AMPk activation, reduction of inflammation and improvement in insulin sensitivity (plus it can help lipids) but without the side effects of metformin (B12 deficiency and reduced muscle hypertrophy). Dihydroberberine is more bioavailable than berberine so a lower dose is needed (100 mg vs 500 mg bid) and it doesn’t cause it GI distress usually.

Tributyrin is a post-biotic composed of three butyrate chains. It’s a less-stinky form of butyrate. Butyrate is great for large intestinal health (feeds the colon cells) and it activates your own GLP1 production in the gut. So, you get many of the same benefits as a GLP1 agonist (obviously in lower doses) such as reduced appetite, improved blood sugar, and reduction of inflammation. You can increase butyrate by increasing fiber, polyphenols, and fermented foods (which feed gut bacteria so they make butyrate) and you can also take butyrate directly.

We’ve combined the two into one pill in HOP Box. Our Ingredients - Hop Box - Human Optimization Project

I’ve seen my HgbA1c go down from 5.4 to 5 with just the addition of this combo. As to my ApoB - my baseline is 30 (I’m ApoE2/E2) so getting in down to 26 was part diet/supplements but mostly luck. :rofl:

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#148

I’ve been taking Fatty15 for about two months. I’d found that I wasn’t reliably taking omega 3’s - I was concerned about lipid peroxidation and hated the huge capsules. So, I decided to give fatty 15 a try.

Fatty15 is an entirely new fatty acid that seems (at least in early studies) to do as much or more than omega 3’s. It affects all 12 hallmarks of aging, activates AMPK, and improves lipids. I take two capsules a day (twice the regular dose).

I don’t know that I’ve felt much but it might have contributed to my ApoB going even lower than baseline (30 to 26).

We need more studies to see if it’s additive to omega 3’s or if we can even replace omega 3’s.

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#149

Just curious why do you mention your Apoe status in relation to apob values?

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#150

ApoE2/E2 variants (only 1-2% of the population) can have very low LDL and TGs, as well as low ApoB.

I am E2/E2 and my ApoB at baseline (without drugs) is 30. I mentioned it to point out that, although I have a nice low ApoB, it’s not because of anything I’m doing right - it’s mostly just luck.

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#151

Urolithin A and Fatty15/ C15:0 (pentadecanoic acid) are the 2 I would love to try if they weren’t so expensive. Also Pendulum Akkermansia.
I need to look at comparisons of Dihydroberberine with liposomal berberine for making berberine more bioavailable.

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#152

FWIW, here is a study that speaks to your question.

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#153

That’s actually very interesting. My husband and I are both apoe3/4. My LDL is low while his is high. He’s more into saturated fats than I am so this will be food for conversation.

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#154

Thanks for that color.

(A) can we measure the effect of Omega 3 oxidation in our body? Do you think those oxidation risks are the same from eg eating salmon or sardines?

(B) have you tested / is there a test for Fatty15?

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#155

I haven’t tested. You can certainly test omega 3 and 6 levels (ex: Omegacheck blood test) and there are indirect markers that should improve (ex; lipids, blood sugar, hsCRP for inflammation) but I don’t know how fatty15 affects these tests. It’s a good question. It’s a pretty new product but very interesting.

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#156

Got it, ok. Thank you.

#157

Nice, fun website! I like that you’ve focused on more bioavailable versions of your ingredients. Looks like a great overall combination. What’s your feeling on how supplements/ interventions (including rapamycin) are synergistic/complement each other or combinations that cancel out, overlap, are redundant or have outright negative interactions?
Fisetin and Quercetin, as just one example, are quite similar. When trying to reduce our stack, do we need both?

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#158

Thank you. We’ve had a lot of fun trying to make this “longevity” stuff a bit more playful and interesting to the average consumer. With Fisetin and quercetin - we included both but at low doses because we also have other polyphenols like CurcuPrime and Apigenin and there’s certainly overlap in mechanism of action, etc. And, our goal is to change the formulation as the science changes, so we’re always on the lookout for more studies.

I’m a fan of Rapamycin and take that daily. I suspect (but don’t know for sure) that the combination of Tributyrin + Dihydroberberine in our Equilizer probably work as well as Acarbose (but without the gas!) since Acarbose both lowers blood sugar and improves gut microbiome. We’ve had a number of HOP Box users who brought their A1c down by 0.5 without any changes to lifestyle.

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#159

Daily dosing of rapamycin is not common among the people here. An intermittent dosing strategy is most common here. May I ask what made you use a daily dosing strategy?

#160

Sorry. I meant weekly. I take 6mg ish per week.

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