But remember, we are not mice. High protein consumption in humans is generally beneficial when it comes to avoiding frailty as we are not nearly as cancer-prone as mice.
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That Gregor plant-dude guru looks like a sickly old man and he’s also a follower of a low protein diet.
1.6g/kg of protein per day hasn’t killed anyone yet.
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He’s a counterexample to your statement.
SNK
#411
Trust me I’m doing my part consuming 3-4 Lbs organic steaks lathered in butter and wine sauce daily! 
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A high fat diet has shown to also be detrimental to longevity in mice and obviously high cholesterol and alcohol consumption are proven to be damaging to humans.
I hope to look like Bob did in his 80’s.
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If you’ve seen recent photos of Clint Eastwood and Gene Hackman, both in their early 90s, on the one hand, they aren’t looking so good, but on the other they’re still alive and have (so far as one can tell) a decent level of mobility and mental acuity.
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Alex
#415
No have not tested yet. But I can say that intermittent doses work well for how I feel. Consistent doses caused me some minor performance problems.
Jack LaLanne, body builder extraordinaire. He lived to be 96. He lost all of his muscle at the end though.
His life and death also stresses why you should see a doctor.
LaLanne often said, “I can never die; that would ruin my image!” The fitness guru died of respiratory failure due to pneumonia at his home on January 23, 2011. He was 96. According to his family, he had been sick for a week but refused to see a doctor. They added that he had been performing his daily workout routine the day before his death.
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Seems like he was doing well until pretty late in his life…
But he worked out daily, religiously.
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Folks, please stay on-topic, don’t tell other people what to do (its fine to share your experiences), and stay focused on this science (opinions without research behind them are not worth much here, unless you’re a demonstrable expert in the topic area).
This is not a place for political discussions, or ad-hominum criticisms.
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…a lot of information here. Thank you. I’m surprised it didn’t mention HMB more or go into more detail as to the benefits of its use to prevent and reverse sarcopenia.
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KarlT
#448
Not really directed at older ages but very informative
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The full episode was very informative. My summary from memory (please provide corrections):
- older muscle behaves the same as younger muscle as long as you use it. It’s never too late to start
- muscle protein synthesis (MPS) is triggered by leucine (and lysine and methionine?) but is limited without sufficient EAA. MPS can last 5-6 hours
- Muscle is more responsive to MPS after exercise. Type 2 muscle fibers are the larger fibers used with heavy weights and when lighter weights are lifted to “failure”. These are the fibers lost in aging and retained / gained by doing harder, shorter exercise (not walking on flat ground, but walking up stairs)
- eating protein before bed increases overall MPS (better to use every 5-6 hour time slot)
- muscle is very responsive to protein in few hours after exercise
- use supplements (including protein powder) only after establishing a healthy diet. Don’t use supplements to avoid needing a healthy diet.
- animal proteins are better than plant proteins, especially within whole foods. Vegan whole food diets can have minimal MPS effects.
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Hi there, do you know where I could source (buy) this?
Thank you!
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SNK
#452
btw, Is TM5484 same class as TM5614?
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SNK
#453
CTStan, 148lbs sound a bit low to me my friend. Indulge in some pizza and ice cream often and put on some fat, forget about the muscle part. Muscle is always good but if older than 80 FAT is king. Tim I just sow you at 135lbs and you are almost 6 feet, dude, are you trying to disappear, put on some weight man, and do it fast. If you are over 5 foot 10 the lowest a man should go is 165lbs. Anything lower would be uncivilized (as per an old commercial)
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By far, the biggest thing is a consistent, fairly intense, strength training routine. That is the stimulus for muscle growth and maintenance.
To that end, anything that helps you train and recover is worthwhile.
For example, if curcumin or fish oil helps your joints, it will indirectly improve the ability to train. Or maybe some carbs and protein help with recovery.
There’s still a lot we don’t know (eg why Rapa does not empirically seem to reduce muscle mass despite turning off MToR), but the training stimulus seems to be the most important factor.
CTStan
#455
Thanks for your concern. I agree my weight is a little low, but attempts to add fat are very difficult for me. Pizza and ice cream isnt an option when HbA1c is 5.6.
By the end of this month, I am scheduled to determine (and report) if I’ve added muscle mass or body weight.
I exercise daily and continue to get stronger. That is evident in the steady progression of maximum poundages I can use. But whether that has translated into increased body weight, I dont know yet. I kind of doubt it.
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