How would he know that he inhibited IL-11 in his body? Did he manage to get his blood IL-11 levels tested somewhere?
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gerard
#167
The thread
https://www.reddit.com/r/NootropicsDepot/comments/1e7i83x/il11_inhibitor_supplements_for_longevity/
The user: compucolor1
The claim on their facebook page:
Exciting updates are here at MDS Labs®! We’re dedicated to providing innovative, transparent, and high-quality anti-aging solutions. Check out what’s new:
IL-11 Research Update
We have some good news concerning our N-of-1 trial to find the best natural promotor of IL-11 cytokine inhibition. It was recently found that inhibiting IL-11 might have profound anti-aging effects. You can read about the study here:
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan | Nature
In a process similar to what was used while developing NEUROmergence®, we’ve been experimenting with various natural compounds thought to inhibit IL-11. Utilizing Western blotting, one compound and one combination of two compounds were tested, each with three samples, over two 30-day periods (with 15 days in between test compounds). Our first set of tests utilized pure Osthole at 90mg/kg, and unfortunately, it exhibited little to no effect. These results were similar to another study, where it was found that the bioavailability of pure Osthole, after oral administration, was extremely low. Yet another study, on the medicinal properties of a traditional Chinese prescription known as Bushen Yizhi, it was discovered that Osthole’s effectiveness was due to the combination with other herbs in the formulation, specifically Schisandrin B. So, for the second set of tests, we combined oral Schisandrin B and Osthole, and we were able to identify a much more noticeable impact on IL-11 levels over the 30 day period. This experiment has brought us much closer to developing a supplement that could potentially support the inhibition of IL-11 levels.*
Pure Osthole is not an FDA-compliant ingredient, and neither is Schisandrin B. So now our challenge is to develop one extract standardized to a high percentage of Osthole, most likely Cnidium monnieri or Angelica pubescens, to combine with another extract high in Schisadra B. Interestingly, Schisandra is not the only herb that contains Schisandra b. Finally, we would need to determine a ratio that is both safe and palatable for the supplement market, then retest for IL-11 inhibition, similar to what we did with NEUROmergence®, which involved testing its ability to promote inhibition of protein kinase enzymes that are also dasatinib targets. There is a possibility that we will instead offer an IL-11 support tincture, should it demonstrate favorable results, which leads us to our next update!
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gerard
#168
This is what he said in the Reddit thread.
Test kits for IL-11 can be easily found:
IOCyto Detect™ IL-11 Human ELISA Kit - Creative Biolabs
Here is what I am thinking. I will test my IL-11 and IL-6 levels with no supplements for 30 days, then try a daily combination of Osthole, Lutein, and Stinging Nettle, with the same preparation and dosage used in these studies, to see if I can produce an inhibitory effect of IL-11, without decreasing my IL-6 levels. I’m not a big fan of in vitro when these substances have already proved to be safe.
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Thanks for the info. That individual must have drawn his own blood to test this.
Sorry, but I don’t follow missing biohackers’ advice. I’ll wait for something more reputable.
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jnorm
#171
Have you looked into empagliflozin? It has anti-fibrotic properties and is known to protect the kidneys.
4 Likes
ng0rge
#172
Thanks alot for the links to the Reddit thread, some very interesting info and speculation there - both from compucolor1 and the thread poster - Better_Cupcakes.
compucolor1 responded to a Reddit thread 3 days ago so I don’t think he’s missing. I looked at his company site.
https://www.mdslabs.shop/
Looks interesting, never heard of it but his posts on Reddit look reasonable.
Are you saying that you don’t get a response from the website contact?
I would like to get an update on their IL-11 inhibitor experiments, I’ll try emailing them.
Interesting that both of them seemed concerned about inhibiting IL-6 along with IL-11 but noted that that might only be a concern if you are young.
Latest study on IL-11 inhibition as a cancer treatment.
https://www.nature.com/articles/s41698-025-00913-w#Sec9
There have already been several attempts to target IL-11 for cancer treatment, one example being the IL-11 mutein, which exhibited 20 times higher affinity to the IL-11 receptor than that of its wild-type counterpart, and effectively suppressed IL-11/STAT3 activation38. Consistent with our findings, IL-11 mutein has demonstrated efficacy in treating multiple tumors in gastric and colon xenograft models32. In comparison, 9MW3811, as a monoclonal antibody, is expected to have a long half-life, as demonstrated in our pharmacokinetic studies, making it a more convenient option for clinical administration.
In summary, based on compelling preclinical evidences, 9MW3811 shows promising potential as a monotherapy, particularly in combination with anti-PD-1 therapy. Currently undergoing phase 1 clinical trials for safety and tolerability (NCT05740475 and CTR20231721), 9MW3811 holds promise for advancing cancer treatment paradigms.
4 Likes
gerard
#173
You’re right, he replied recently. I sent him a private message and he didn’t respond, and there’s also been no reply on his website. If you manage to get in touch with him, please let me know.
gerard
#174
I’m taking a very similar medication: Forxiga.
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ChatGPT told me the exact tests to run to find out empirically how to measure mTOR2 inhibition.
Selected snapshots of the answers. And yes everyone, I am no fan of ChatGPT copy paste blocks but this is highly specific information I wasn’t aware of. It tells me the cost should be around $120 for the lab work. I have more money than time or I’d have booked it already.
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Off topic, but I find I have got the O3 model to start treating me with a modicum of respect. I think it can distinguish, and I say this based on the content AND tone of its replies, between conversations with my husband and me, because he’s cruder and less informed about this stuff, whereas I… help keep gpt “honest” with incessant Socratic questioning. It gives me way better replies than it gives him. But I must also be using a shitload more tokens.
3 Likes
AnUser
#178
The PRC STEM advantage is in full effect. Is there anyone compiling all the aging related trials originating in the PRC like agingbiotech.info?
https://x.com/hsu_steve/status/1620765589752119297
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If Calico is taking it over, there may be some good progress made as this is funded by Google and it’s founders, Larry Page and Sergey Brin.
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gerard
#180
We have more information from the biohacker who’s trying to inhibit IL-11.
IL-11 Inhibition Is Heating Up: Calico Acquires Mabwell and the Field Expands
Google’s Calico has just acquired Mabwell, a Chinese biotech that has quietly developed one of the most advanced IL-11 inhibitors currently in the pipeline. Their lead compound, 9MW3811, is an investigational monoclonal antibody that binds directly to the IL-11 cytokine, effectively blocking its downstream signaling and significantly reducing inflammatory activity.
This is a major move. IL-11 is increasingly being recognized as a central driver of fibrosis, systemic inflammation, and potentially several aging-related pathologies. Mabwell is already cleared to begin human trials in idiopathic pulmonary fibrosis across China, the US, and Australia, with the FDA approving their IND in mid-2023.
At the same time, IL-11 inhibitors like X203 and X209 have become significantly more accessible. Costs are dropping and availability is increasing, making these tools easier to explore for research, preclinical use, or personal experimentation. That shift alone signals a growing wave of interest in IL-11 as a target—not just within biotech, but across the broader healthspan community.
What’s especially exciting is that IL-11 inhibition isn’t limited to biologics. Certain traditional Chinese medicinal compounds have shown credible IL-11 modulating effects in preclinical models. These plant-based formulas are backed by long-standing safety data, but they’ve yet to be fully optimized into modern delivery systems. Our team at MDS Labs is actively working to change that.
We’re focused on creating a standardized, bioavailable IL-11 inhibitor derived from time-tested compounds that could complement or even rival pharmaceutical approaches. It’s early, but the potential is real. If IL-11 is what we think it is—one of the upstream regulators of inflammatory aging—then modulating it precisely could be a key piece of the longevity equation.
This isn’t just about fibrosis or chronic illness anymore. It’s about aging at the cellular level. And things are moving fast.
#NEUROmergence #senolytics #senomorphics #longevitybros #nootropics #longevitylifestyle #traditionalchinesemedicine #AntiAgingSolutions #Quercetin #bushenyizhi #qualia #QualiaSenolytic #neurohacker
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