#464

Sure but those ripples are still much less than with the injectable version.

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#465

Yeah that’s true. If you try it, I’ll be interested to hear what you think. I don’t know if I’ve yet seen any glowing reviews of Rybelsus. The side effects were too much for me, unfortunately. My wife threw up both times she took a 3mg Rybelsus tablet and wouldn’t touch it after that, but she’s had smooth sailing with no nausea on compounded injectable tirzepatide.

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#466

I’m ramping up on my second week, splitting 14 mg pills which is bothersome. That’s why I wanted to look at taking the whole 14 mg pill but every 4 days, then 3 and 2 to end up with the 7 mg daily dose equivalent.
I don’t have weight to loose but I’m desperately trying to lower my own blood glucose production and I want to take the minimum effective dose for that. Today I had my first 2 consecutive days in years with a fasting morning glucose below 100 mg/dl so that’s encouraging.
No side effects so far.

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#467

I too am desperate to lower my FBG, so I’m following your progress with great interest. Any side effects so far?

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#468

No side effects so far but I’m still at low dose: 7 mg every other day (eq 3.5 mg dally) for 2 weeks. I will switch to 14 mg every 3 days (eq 4.6 mg daily) next week.

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#469

Are these the exact prompts you are using to get these graphs? I’m trying them and I’m not getting any graphs. Can you please share the exact prompts you use to get these graphs. I’d love to be able to play with this…

#470

It only works with GPT-4o not the o1-preview

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#471

Is this the same data you’d get from the popular glp1plotter.com ?

#472

No, ChatGPT generates python code that uses libraries to solve differential equations and then run that code.

Here are the exact prompts I used (@RapAdmin might be interested too)

what are the detailed pharmacokinetics of rybelsus compared to injectable semaglutide, including the differential equations ?

[…]

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[…]
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Amazing in fact.

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#473

I posted this a while ago: Getting to 10% BF with tirzepatide or alternative?. TLDR: “I am 45 years old and aiming to get from ~15 - 17% body fat down to 10 - 12%. I’ve done this in the past with strict keto, intermittent fasting, impaired sleep, and lots of “food noise.” I am unable to maintain this body fat % beyond a couple weeks.”

Still haven’t taken the plunge on GLP-1s, though thinking about giving it a go with Reta now after doing some reading on Tirz vs. Reta. Has anyone done this and had success?

#474

I’m attempting this with Tirzepatide. For me the food noise was rather unbearable after 3ish weeks of a 750 calorie deficit at ~15% body fat. So far, tirzepatide has eliminated the food noise and I’m slowly creeping down towards 10%. Another benefit is that I generally don’t need to weigh food and count calories anymore. I do have a general idea of how much I’m eating in a day, mostly because if I don’t somewhat track it in my head I won’t eat enough and will be in too large of a deficit to have a high likelihood of maintaining muscle mass.

On the other hand, I don’t think these weight loss drugs help with the other challenges of going to low body fat levels and/or dieting for long periods of time. Namely the (potential) collapse of hormone levels like Testosterone and possibly thyroid hormones. This is evidenced by the high percentage of side effects like “fatigue” that are reported in the studies on GLP-1s.

1 Like
#475

That sounds pretty great. Have you had any side effects? Did you consider Reta over Tirz?

#476

Main “side effect” is nausea/pain when eating too much. In my experience this is pretty easy to manage. I learned pretty quickly how to intuitively tell when I’m getting close to the threshold where another bite would cause nausea and/or stomach pain. I had a rather severe immune reaction when I bumped up to 5mg - felt like I had the flu for almost a week. Out of the 4 or 5 following doses I’ve only had a minor immune reaction once (again flu-like symptoms, but more manageable). FWIW, in my anecdotal search this kind of reaction doesn’t seem too common.

I would consider switching to or adding on retatrutide once it’s approved. Insurance covers Monjouro for me and it seems to be working well so I’m not particularly motivated to order retatrutide for now.

#477

I’m catching up on this thread and this comment caught my eye because retatrutide has become very popular relatively recently among bodybuilders on gear (AAS). There’s a lot of discussion surrounding running it at low doses while bulking, with guys having success adding muscle without adding any fat and possibly while losing fat - the recomp objective that’s hard to achieve and usually thought to be pointless to attempt even when on gear. Of course, on cuts they’re running higher doses and stacking it with a lot of other compounds. SLU-PP-332 is often in the mix now too.

I’m also seeing a lot of talk about microdosing cagrilintide with reta, whereas the discussion used to focus on cagrilintide with sema (cagrisema). I’ve been using reta for a few weeks to drop fat, and I have cagrilintide on the way. The thing I love about reta is that I can eat if I want to. What I don’t love is the RHR increase, though it does always tend to drop somewhat after about a month or so.

2 Likes
#478

I know a couple guys using Reta at 1mg weekly who are hardcore workout guys but are not using any PEDs other than the BPC+TB combo. They are both gaining muscle while getting leaner.

I’ve got some SLU-PP-332 coming just to try :slight_smile:

I’ve been taking Reta for 6 months now. My RHR is typically 58 the last 4 months but that is up from 55 before I started with GLP1-R’s 16 months ago.

And yes, with Reta I can eat what I want when I want and it’s pretty cool :slight_smile: That is quite different from Tz which made me a bit food averse and if I ate too much, somewhat uncomfortable.

Went to a new restaurant on Wednesday for the soft opening for friends and family. Had lobster, lobster bisque, clams 2 ways, crab dip, turkey dinner, hot turkey sandwich and a chocolate sunday for dessert. I did not eat that alone, there were 4 of us but the helpings were not “light” I would not have been able to enjoy that with Tz but it was great with Rt. Was up 1.2 lb the next day and 2 days later that was gone… back to my HS grad weight LoL!

6 Likes
#479

https://www.nature.com/articles/s41591-024-03412-w
published 2 days ago on Jan 20th, 2025

Data from about 200,000 participants. New GLP-1 users compared against new SGLT-2i/DPP-4/sulfonylurea users :

“Compared to usual care, GLP-1RA use was associated with a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders, cardiometabolic disorders, infectious illnesses and several respiratory conditions. There was an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis and drug-induced pancreatitis associated with GLP-1RA use compared to usual care.”

(also see x.com)

3 Likes
#480

If somebody could get access to it that would be useful.
In the mean time here are some of the figures from it.

Outcomes with reduced or increased risks with incident GLP-1RA use compared to usual care.
image

Forest plots for systematic evaluation of the effectiveness and risks of incident GLP-1RA use compared to usual care.
image

5 Likes
#481

Longevity’s First Blockbuster

It’s already generating nearly 40% of revenue for major drug companies like Eli Lilly.

It’s projected to generate $126B in sales by 2029.

GLP-1 drugs (like Ozempic and Mounjaro) are a case study in what’s possible when you tackle giant markets that people truly care about. It’s an example of how targeting the root cause of diseases keeps people healthier for longer. It’s an example of our larger thesis of moving from sick care to healthcare.

GLP-1s drugs are a blueprint for the next era of medicine. I can tell you this as an investor who has followed these technologies. And as a person, who started taking these drugs about a month or two ago.

This is just the beginning.

A few years ago, people saw being overweight or obese as a personal failing. That was never 100% true — there is a genetic component to obesity for example. But back then, the idea of taking a drug to magically lose weight seemed crazy.

People say the same about aging. If you ask people if they want to live longer, many initially say no. But if you ask them if they want to feel young, feel healthier, watch their great-grandchildren grow up…that answer changes.

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#482

This has been my feeling more and more those last few months : if we’re talking about longevity and not talking about GLP1 agonists, then we’re wasting time.

At the highest dose, retatrutide works like a statin by slashing ldl levels by 40%. It also actually increases egfr, beating the SGLT2 inhibitors in efficacy. And because of the glucagon agonism, subjects are in perpetual ketosis at the highest doses , even after consuming carbs. That’s in top of the cardio benefits, which even an older drug like semaglutide provides.

3 Likes
#483

And it can be stacked with statins and SGLT2i for additional benefits.