#222

I would love to hear more about the potential of its anti viral protection that @desertshores mentioned.

I’m already taking it but now excited to learn it is possibly preventing me from getting sick

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#223

I remember my grandmother adding it to laundry to make bed sheets brighter. Also, when my poodle was dying from a tic bite, a Russian veterinarian administered an MB IV and told us that the dog would live if not dead in 15 min. The dog lived.

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#224

I prefer LL 37 as it is proven and works amazing. It is in the Cathelicidin family of peptides and is the only known one humans make. It is antimicrobial, antiviral and anti fungal. I cleared up a nagging but minor infection I had for nearly 2 years. It only took 1 week to do what several round of antibiotics could not handle. I stopped the antibiotics 2 years ago to protect my gut.

There is a good amount of clinical evidence for this peptide. Not as much hoping required.

We do a 1 week cycle every month. My thought process on this… various virus and bacterial infections modify our immune system so they can hide. These hidden resident nasties are thought to be the cause of many things, like CVD, dementia, various cancers, and a wide variety of other issues. My “hope” is that regular use of LL 37 may clear some of these out or at least reduce their effect over time.

Exactly what people hope MB will do only with much more clinical evidence.

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#225

How exactly do you use the red light ? I just listened to Peter Attia podcast with Francisco Gonzales Lima, Ph. D. and specifically stated that he wouldn’t combine red light with MB unless you can localize the light to the infection or the tumor. I am not sure if I understand the Biochem fully on this but red light will turn the MB from an reducing agent to oxidizing agent which can be harmful to the tissue.

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#226

Did he give any citations that the combo is an oxidizing agent, and to what extent?

Methylene blue is a redox agent.

I can find no compelling evidence not to use them together. Can you?

I find quite the opposite. Clinics and doctors in several countries are using them together.

I have been using them together for quite some time, and my skin looks much better than that of a typical 84-year-old.

If I were young, I would probably skip the MB, but as I am in the age group with almost exponential risk of dementia or Alzheimer’s, I will take my chances.

We are sailing in uncharted waters when using supplements, etc., which will probably never get any high-quality randomized trials. As of now, mostly we get anecdotal evidence from users and the reporting of doctors and clinics.

As for Huberman, I no longer trust his opinions.

Methylene Blue
Functions as a mitochondrial electron donor, potentially improving cellular energy production
Has antioxidant properties that may reduce oxidative stress
May improve cognitive function through several mechanisms
Can increase cerebral blood flow
Has been studied for neurodegenerative conditions like Alzheimer’s

Red Light Therapy (Photobiomodulation)
Uses low-level red wavelengths (typically 630-670nm) to penetrate tissues
May stimulate mitochondrial function and ATP production
Could reduce inflammation and promote healing
May improve skin health and reduce signs of aging
Being studied for applications in wound healing and pain reduction

Combined Potential Benefits
Enhanced mitochondrial function when used together
Potentially stronger neuroprotective effects
Improved cellular energy production
Increased antioxidant activity"

These are just a few of very many positive reviews and studies of MB + red light therapy.

https://www.sciencedirect.com/science/article/abs/pii/S1572100005000979

Methylene Blue and Red Light Therapy for Dementia, Parkinson’s, and Alzheimer’s Disease

“https://levitasclinic.com/methylene-blue-and-red-light-therapy/#:~:text=Elevate%20your%20cognitive%20function%20and,MB)%20and%20red%20light%20therapy.”

“Perfect Pairing: Harnessing the Anti-Aging Power of Methylene Blue and Red Light Therapy”

“Harnessing the Power of Methylene Blue and Red Light Therapy in Functional Medicine”

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#227

A most excellent point. While you are ahead of me by a decade or so, I feel the same way. I’m willing to take some “risks” today that I might not have 10 years ago.

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#228

I came across this several months ago and it gave me pause: Removal of red light minimizes methylene blue-stimulated DNA damage in oesophageal cells: implications for chromoendoscopy - PubMed (available on Sci-Hub).

#229

Honestly I have hard time wrapping my head around this one. I had Biochem about 30 years ago.
I am not a PA member but maybe someone who is could get the transcript of that podcast and get the PhD exact wording.

#38 – Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer’s disease treatment and prevention – is AD actually a vascular and metabolic disease?

If I were young, I would probably skip the MB, but as I am in the age group with almost exponential risk of dementia or Alzheimer’s, I will take my chances.

MB sounds very promising otherwise. I started my mom on a trial low dose 7mg a day. I take about 2.5-5 mg a day on work days. I took 5mg with 250 of liposomal NMN and I had a head rush for a couple of hours but incredible alertness for 9-10 hours.

#230

Another good read from Healthspan.

Beyond Plaques: How Methylene Blue and Ketones Address Vascular-Hypometabolism in Alzheimer’s Disease

Alzheimer’s disease (AD) is often associated with amyloid plaques and neurofibrillary tangles, yet growing evidence supports a vascular-hypometabolism hypothesis in which cerebral hypoperfusion and mitochondrial dysfunction—particularly at the level of cytochrome c oxidase—drive early disease processes. Research led by Dr. Francisco Gonzalez-Lima highlights pronounced deficits in oxidative energy production within critical brain regions such as the posterior cingulate cortex, correlating with cognitive decline and disease duration. These findings challenge the predominant amyloid-centric model by emphasizing the role of impaired blood flow and metabolic failure. Consequently, interventions targeting these core vulnerabilities—including methylene blue, ketone-based therapies, and near-infrared light—show promise in restoring mitochondrial function, enhancing oxygen utilization, and potentially slowing AD progression. By reframing AD as a hypometabolic disorder rooted in vascular and mitochondrial insufficiencies, new prevention and treatment strategies may outperform traditional approaches focused primarily on amyloid pathology.

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#231

#38 – Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer’s disease treatment and prevention – is AD actually a vascular and metabolic disease?

I can’t find the transcript but listen to the podcast at 2 h 11 minutes. Attia askes if the infrared and MB can be combined as treatment for Alzheimer’s and Francisco Gonzalez-Lima, Ph.D specifically says NO. He then proceeds to explain that photon absorption by MB causes ROS generation and unfortunately he doesn’t fully elaborate but pivots to how this is useful in pathogen or tumor eradication. This is confusing because he makes a case for using both in specific cases I guess to make a distinction. Most likely ROS generation in the frontal cortex in the absence of infection or tumor growth is not favorable.

Since there are no studies that I know of, combining both modalities in treatment or prevention of Alzheimer’s, I find his statement compelling enough to avoid using both modalities. I actually thought about getting the IR device for my mom but decided to start MB - it’s easier to pop a pill - compliance wise.

This is a problem with kitchen sink approaches like Bryan Johnson, with each added variable the potential interactions and unintended consequences arise.

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