Neo
#22
Sean Connery in the lead!
Neo
#23
Hi John, what did you think about Jean Herbert’s presentation at Foresight earlier today - or actually I guess yesterday for you?
It was a good presentation, but i still think we need to actually fix the aging process. The concept of a full body transplant does not attract me.
1 Like
Neo
#25
@John_Hemming I’m 100% in agreement that we need to fix the aging process.
Just seems good that the world diversifies its approaches and that this could also be a bridge for many in case fixing the aging process in other ways ends up taking too long time.
I think I know how to fix a lot of the aging process.
3 Likes
Neo
#27
@Phil_Van_Treuren @ng0rge @AnUser @RapAdmin @John_Hemming @scta123 and others
On the brain, it seems like ARPA-H, the US Gov’t new DARPA (the guys that invented the internet, GPS, etc) will be doing a big program in how to slowly introduce new brain tissue to adult brains. (which if done in waves, eventually could replace your brain “substrate”, while still retaining your memories, experiences, and “you, yourself”). See e.g.
https://hebertlab.einsteinmedneuroscience.org/about/
MIT Technology Review
The US government just hired a researcher who thinks we can beat aging with fresh cloned bodies and brain updates.
4 Likes
LaraPo
#28
It’s better to have old head and young body than old head in addition to the old body. Old brain may get rejuvenated from the young body and old face can undergo a face lift.
4 Likes
Jonas
#30
Yes - Karl is a Caloric Restriction enthusiast and doesn’t believe that the evidence shows he’ll get much additional benefit from rapamycin. Karl is very diligent and discipline in his diet; probably not a path most people want to (or can) follow.
Karl also tends more towards the Aubrey de grey camp - looking for biotech innovation that can rejuvenate humans, not just provide smaller incremental benefits like a 15%, 20% or 30% healthy lifespan increase (although Aubrey, with he RMR project is becoming more interested in rapamycin).
4 Likes
Jonas
#32
What are the 2 drugs that can extend life by 10 years per the guy named Greg in this video (timestamp 10:53)
1 Like
I don’t know, but the key words there are “could potentially”… in other words one-day, maybe (but a long way away)…
Here is the Juvenescence product pipeline Our Pipeline - Juvenescence
so these are what they are working on…
1 Like
AnUser
#34
Until it’s close to being available or available I would be very skeptical. If ARPA-H is anything like DARPA it funds moonshots.
1 Like
I have been explaining on this forum.
Neo
#36
Sorry, I’m not at all saying that the ARPA program means everything is now solved.
Rather I just mean that all the sleep, fasting, rapa, other meds and supplements are only going to help people so much (10%, 20%, max 30-40% health and lifespan increase?)…
If we really want people, loved ones and ourselves to be able to live vastly expanded lives in quality and longevity we needs scientific, technological and medical advances.
And in that context it seems that you agree that solving aging via small molecules and perhaps even via partial reprogramming, crispr and other gene therapies is still an open and MASSIVE question (I take it because you often mention biostasis/cryonics).
Replacement of the body (via brainless clone or other tissue engineering). And then either rejuvenation only being needed for the brain (which already will last longer as it’s in an optimally young healthy body again) and/or doing stepwise brain enhancement with young, healthy brain tissue per the ARPA-program and other efforts, seem as smaller scientific and engineering feats than solving all aspects of aging via molecules. Hence, anything that can support that path would be helpful.
Truly encourage everyone to take a skim through the slide deck here:
There is also a good overview video.
4 Likes
ng0rge
#37
Neo, I agree with you in concept, but as a practical matter, I think there are much more important issues to solve. I’m old enough to be concerned about extending my lifespan from say 100 to 120 and I think rapamycin might do that, but beyond that I really start looking at what the world will be like when I get to 120. We really need to focus our resources on solving the biggest problems - if the world goes to hell, what’s the point in living longer?
I also agree with you that if we can renew the body and other organs that the brain will also function better for longer. I think it is simpler and more likely to renew organ by organ rather than the whole headless body - that’s complicated and a good ways off whereas I think we’re much closer to being able to clone and transplant organs. The complicated issues are the brain and the whole inter-related body organism - the individual parts are much easier and I think can extend life considerably. As we move into the future we’ll have a better understanding of how to proceed so given another 50 years, I can put off thinking about brain or head transplants, or body clones (or god forbid cryogenics) until the picture of the future gets a little clearer. I will certainly feel better when it looks like we have finally turned the corner on our social and environmental and distribution of wealth problems.
1 Like
AnUser
#38
I don’t think there is any way brainless clones will be grown in the U.S. the way it is now. If a billionaire is going to fund it it probably must be done in a city-state where it is aligned with the public there what they believe. With a large enough of a military with Anduril drone swarms to protect it. Once the brainless clones and brain transplants are done successfully maybe the U.S. or other countries perception will change to that fact. As other people maybe wants to get access to it. Otherwise once the first video of a brainless clone shows up on YouTube or X you’ll have people show up to terror-bomb the building like the terrorists in Contact. In the best case scenario some people in the U.S. government starts screeching and put their thumb on the scale to shut it all down. Realistically, it won’t ever happen because of these things, at least not in the U.S, but maybe in a free and protected city-state where it’s aligned with its citizens.
3 Likes
ng0rge
#39
I agree, even apart from the bio-tech medical issues, there’s no way to get past the social political issues at this point.
1 Like
JKPrime
#40
Body replacement including body component replacement ( such as cardiovascular system) will be needed. Further human body will need to rearchitected for longevity. However, unlike you I’m very doubtful that any simple drug intervention including rapamycin will be able to extend the max lifespan of already long lived species like humans. Square the mortality curve, sure. We are already longest living among monkeys and primates and fine tuned for longevity. 120 years is the max and increasing that will require major changes.
1 Like
How does this solve dementia?
.png)
