#41

I’ve taken KE4 while doing high volume running training to help with recovery. 5-10 ml before bed. It doesn’t taste that bad. It makes me feel more rested the next day.

#42

Radiata, I may have used the wrong term when saying “energy boost” in an earlier message in this topic. So, I’ll ask in a different way. Does the KE4 provide the fuel you need to complete the run without exhaustion?

#43

I’ve never had a great experience with it during exercise. I’ve tried drinking an entire bottle during training on 2-3 hour runs, and up to 3 bottles during ultra events of 12+ hours in addition to gels, but never really felt much of an extra boost like they described in the trials to develop the HVMN KE.

I like it for recovery because it apparently raises EPO and helps with training overload:

Exogenous ketosis elevates circulating erythropoietin and stimulates muscular angiogenesis during endurance training overload - PubMed.

But, it’s also probably raising mtorc1, so it may not be great to take it around a rapa dose:

https://www.sciencedirect.com/science/article/pii/S2468867319300586

Presumably due to the expedited deactivation of AMPK [60], mammalian target of rapamycin complex 1 (mTORC1) signalling was increased following KE ingestion. The combination of reduced protein catabolism seen during exogenous ketosis [57,58] and potentially increased protein synthesis through mTOR signalling may help maintain muscle mass, which can be challenged by prolonged endurance exercise [62].

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#44

A more nuanced study of ketones on mouse lifespan. Good at older ages or when damage has already started, not great at younger ages.

1,3-BD extended the life span of aged and ApoE −/− mice, KBs may have an important role in tissue repair, as suggested by recent studies… By contrast, 1,3-BD diet from early life was associated with higher mortality, although the reason for this remains unclear

Source: https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13833

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