#41

Hi!
My partner who is 55 years old just got results of eGFR and it is 70 ml/min/1,73m2.
His Creatine level is 103 umol/L
He is very masculine , he is 190 cm tall and has 100kg and doing all kind of sports.
Also he lost 10kg in last 6 months.
Also he was taking 5mg of Rapa weekly for last 5 months.

I saw calculator of CKD and when I put his high and weigh the results of CKD are much better than results we got and in normal range.

Could anyone can tell me is there possibility that result of eGFR are 70 due to his high Creatine which is due to his big muscle mass?

Thank you very much!

#42

Creatinine can be high for people with high muscle mass. Also exercise itself can increase creatinine.

#43

He should get a blood test for cystatin c. This is a much more reliable estimator of GFR, especially in those with significant muscle mass and/or who exercise and take supplemental creatine.

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#44

Thank you on information.

#45

Thank you. very much.

#46

Yes, my eGFR calculated from creatinine is 69, from Cystatin C is 113

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#47

It seems likely statins improve kidney function and reduces decline in kidney function:

eGFR increase of 1.3, 2.6, and 3.9 mL/(min·1.73 m2) over a 5‐year period for placebo, atorvastatin 10 mg, and atorvastatin 80 mg, respectively.

Finally, the proportion of patients with a decrease of >30% in eGFR from baseline to the last visit was calculated. The percentage of patients with a decrease >30% were 2.5% (95% CI 2.2% to 2.9%), 2.1% (95% CI 1.9% to 2.4%), and 2.0% (1.7% to 2.4%) for the placebo, atorvastatin 10‐mg group, and atorvastatin 80‐mg group, respectively.

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… In the pairwise meta-analysis we showed that use of statins lowered the rate of annual kidney function decline by 0.61 mL/min/1.73 m2 and reduced the amount of proteinuria by −0.58 (95%-CI −0.88; −0.29) standard deviations per year.

Our results are in line with a recent meta-analysis Su et al. which reported that statins compared to control led to a 0.41 (95%-CI 0.11; 0.70) mL/min/1.73 m2 slower annual eGFR decline and a reduction of −0.65 (95%-CI −0.94; −0.37) standard deviations in proteinuria…

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