Lately I’ve been taking the equivalent of 12 mg every other week.
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AnUser
#62
Any reservations for using everolimus instead? Why do you take it less frequently than every week but with higher dosing?
Thanks. I’m happy to see I’m not out on a limb with my own dosing (essentially the same as yours).
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I think everolimus would be fine. As for why I take it less frequently. I think the evidence indicates that that will maximize the benefits while minimizing the side effects.
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adriank
#65
Hope so, I am not going to try everomilus until there is more data.
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Yesterday I took comprehensive blood tests and other tests because it is now two years since I decided to start taking a low dose of rapamycin once a week. Now afterwards was it the right decision for me? I would say yes. Firstly because it has totally stopped my chronic bleeding gum that I have struggled with almost throughout my life and different dentists, hygienists and others have not been able to help. But when I started taking rapamycin then after a while the bleeding just stopped. So I’m very happy that I found a solution for this because chronic bleeding gum increases the risk of different age-related diseases.
Secondly I think this decision to start taking rapamycin has forced me to deepen my knowledge around how to self-experiment in a better way, to build up a professional network that I can use but also deepen my understanding around my own biology and how I work. I think all this will be very valuable for me when the big breakthroughs in the longevity field hopefully come because the data and safety around these future interventions will most likely not be perfect. So I guess I will need to take higher risks later in life to increase my odds of not dying and the thing I’m doing now is to prepare myself for that.
Thirdly it is also important for me to deepen my understanding around mTOR inhibitors to see if it may be a promising intervention to use when Rapamycin Longevity Lab develops advanced combinational therapies. My current view is that it’s a mistake to not use mTOR inhibitor as a base ingredient in combinational therapies for longevity. But we need of course much more than just a mTOR inhibitor such as rapamycin to radically extend lifespan.
But now it’s time for me to stop taking rapamycin for three months. The reason for that is that I want to see if some biomarkers improve or worsen and also see if cycling rapamycin may be good. I will take different tests before and after. I have also added tests from TruDiagnostics and GlycanAge because I’m curious to see if something can be detected by them. When the three months has past I will start taking rapamycin again and it will be very interesting to see if some changes can be detected. The last thing I will do this year is to add a glucose regulator to my protocol. Probably Acarbose but it could also be Canagliflozin or some other one.
In around one month I will get my results back from the tests I have done. Let’s see if they also indicate if it was a right decision for me to take rapamycin or not. A bigger summary on that in the future!
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AnUser
#67
How are your apoB or LDL-C levels doing, if you want to share? Done anything to change those for prevention of ASCVD, as your levels were somewhat high for APOB in the past, or not for now?
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Below is the biomarkers that I have gathered throughout the two years. It will be very interesting to see the next data gathering. Jan 2023 was pre data before I started taking rapamycin.
I don’t take any medication for lowering LDL or ApoB but I did some changes in my first meal intake during last year which may have had some effects. You can read more about what I did in this post.
https://x.com/KristerKauppi/status/1761315679582466488
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Do you do aerobic and/or strength bearing exercise? VO2 max? You might find a boost or decline in capacity during your 3 month Rapamycin embargo.
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AnUser
#70
You might want to lower that further, I’ve written a good review here on the topic here: Apolipoprotein B (ApoB)
Basically having an apoB of 100 mg/dl rather than 70 mg/dl doubles your lifetime risk of CVD events like strokes or heart attacks, based on data from genetic studies. It’s in that post with a source.
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I have not done a VO2 max test but in the gym I have experienced progress but I got one shoulder injuiry last year around March which forced me to rehab for many months but now I’m coming back step by step.
Thanks for highlighting this! I have talked with my physician about starting low dose of Rosuvastatin but I wanted first see what effects I could achieve with only diet changes. So that will come but again thanks for pointing this out. I really appreciate it!
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