#82

Don’t jump on the N=1 bandwagon just yet.

“Bothersome tinnitus prevalence was significantly higher among cannabis users relative to nonusers”

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#83

Is there a study that shows this?

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#84

To move back to the topic of this thread … and ask something that has been asked umteen times before:
All the studies point to sildenafil being protective against AD, but where is the evidence that ALL the PDE5i’s are equally effective? In particular what about tadalafil?

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#85

That’s probably right. I don’t recall any measurable effect on tinnitus when i was smoking about ten years back.

#86

Dose dependent effect suggested on this link and was all pde5i

Here is one on PD similar pattern

We would also expect it to be mechanism of action … not the actual structure of one vs another and this study suggests that. It would logically extend having a form with a long half life would expect to have the most benefit.

There isn’t a good trial showing this definitively, but the group of studied in my reading has me looking at a sustained serum level as likely to yield highest benefit.

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#87

@Deborah_Hall @SNK

Ever use of marijuana and each additional marijuana-year were associated with a 6-month (P < 0.001) and a 2.5-month (P < 0.001) higher average in GrimAge acceleration (GAA) using generalized estimating equations, respectively. Recent use and each additional day of recent use were associated with a 20-month (P < 0.001) and a 1-month (P < 0.001) higher GAA, respectively.

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Cannabinoids/cannabis/CBD/THC - can they slow aging in strange ways?
#88

I tend to agree. I experienced no positive effects other than falling asleep. actually, it was very inflammatory in my case, that is why I wasn’t a fan of recreational use, and never used as such. I also thought that its use made one easier to forget things (forget to do something you were planning on doing). However, it did definitely have a significant calming effect which always resulted in making me fall asleep (if I were having difficulty sleeping).

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#89

Has anyone found a prospective study for pde5’s in Alzheimer’s in people with or without ED?

#90

I have to say, I can only tolerate 2.5mg cialis per day. Otherwise I get a stuffy nose, acid reflux, and red eyes. I’ll take more if necessary for sexual reasons but if we leave that aside, 2.5mg is I can handle before side effects get to me.

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#91

Association of Cannabis Use With Cardiovascular Outcomes Among US Adults

Conclusions

Cannabis use is associated with adverse cardiovascular outcomes, with heavier use (more days per month) associated with higher odds of adverse outcomes.

https://www.ahajournals.org/doi/10.1161/JAHA.123.030178#d1e765

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#92

Actually just got on generic Cialis(Tadalafil) for its anti inflammatory effects throughout the cardiovascular system and brain. 5mg a day has had no negative side effects, other than some mild nose stuffiness the first couple days or so of adjusting to the new drug.

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#93

Given that Viagra stimulates blood vessels and blood flow, would one expect this would speed healing on the theory it increases blood flow to the needed area?

#94

I wouldn’t count on it. It does have some benefit when it comes to increasing the blood flow but nothing that I have read to suggest that it helps with wound healing.

#95

Yes Cialis (Tadalafil) has the same effect. Matt Kaeberlein has been considering taking Tadalafil for a while and said in a recent podcast that findings from a new study have convinced him to start - I think he said at a dose of 5 mg/day. Here’s the podcast, which is about 14 medications linked to lower death rates in humans:

My husband recently started taking Cialis for BPH, which we were happy about due to the longevity benefits. Also helps lower his BP.

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#97

Apparently you don’t know much about Cialis because 5 mg/day doesn’t have that effect. He is taking it for BPH and nocturia.

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#99

For someone with erectile dyfunction @SNK who needs a lot of help in that area, 5 mg might do it! I’m glad it worked for you.

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#101

@SNK can you be more respectful and keep the focus to the topic - AD in this case

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#103

I think we should keep building a community for everyone and that we all - including you - should not make it uncomfortable for anyone (whether you think they are “mushy” or not).

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#105

I just clicked on “ignore” so I don’t see any more his posts, Neo, since I find the so-called “humor” to be merely a game of pushing the boundaries of what’s acceptable while trying not to get banned. Ignore = gone.

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#107

Thanks, it’s appreciated.

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