#22

Yes, I’ve tried Keto and it dramatically raised my LDL-C and APOB. I gave up Keto after that as CVD is the biggest killer in the US and my A1C is only slightly above my target.

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#23

That’s not always the case for HbA1C. Plenty of people, including myself, have a high HbA1C (6.0 for me) on a strict keto diet even after 1 year. Since then I switched to a less strict low carb diet that include more veggies and fruits so I’m still in ketosis (measured with Keto Mojo) but my HbA1C is still 6.0.
In my case it’s my liver that generates all the glucose I need (too much in fact) even if I eat 0 carbs.
Currently trying Tirzepatide and, at least according to my CGM, it seems to be better. I will do an HbA1C test in a few weeks.

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#24

This seems like a fairly common phenomenon that keto proponents rarely talk about. I had a similar experience - strict keto resulted in 100-105 fasting glucose. Switching to a high carb and low fat diet reduced my fasting glucose to 90 or so fairly quickly.

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#25

Does anyone know how long after stopping Rapa, the labs come back to normal?

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#26

I agree it’s common. I talk about it. I worry about it. I’m not as keto as I once was and the problem is smaller. I’m still low carb, just not low enough to make many ketones. Usually.

#27

Also at @dicarlo2, this may be because “strickt keto” should also have a limit on proteins (some here on this forum deny that vehemently). The liver makes glucose from proteins. If you eat yet more oil like MCT and ketones, the liver could not make all that sugar.

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#28

Yes, the original strict Ketogenic Diet is 4:1 or 3:1 ratio of fats:Carbs and Protein combined, but that ratio is weight(g or oz if in US), so in Calories the 4:1 ratio is 90% fat and 10% other and the 3:1 ratio is 87% fat, so very high. This was used to treat epilepsy in the early part of the last century.
Fat has 9 calories, so 9 x 4 = 36, Carbs/Protein has 4 Calories, so 1 x 4 = 4.
36:4 = 90:10 ratio.

#29

I take rapamycin 12mg every fortnight, my LDL cholesterol is under 50 and my A1C is 4.5 without any medications to control them.

Responses to rapamycin vary so the blanket statement of needing blood glucose/cholesterol drugs isn’t true for everyone.

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#31

Yes, but taking metformin regardless is something I would do just because the risk is virtually nothing, and adding 5mg Crestor or 10mg Ezetimibe would get your ApoB in an even better place. You didn’t mention triglycerides either.

#32

Thank you for your concern, but maybe it is not quite addressing the issue, which was about not to rapa without the stata, I mean statin. Sure, do early what you can do, such as exercise, but statins? See, there is this paper,

https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391

which has been “discussed” on this forum before, but not at all fairly, certainly not regarding how statin side effects have been hidden, or review articles misrepresenting the reviewed research. See, if they all really want you to take something, it is better to be careful, and on this forum there is very little critical thinking, just chatGPT.
The Yale paper on long covid being indeed rather side effects from the clot shots, it is discussed in many places right now, but not here. Is it not strange that people interested in longevity do not care about the establishment regularely making them cut years of their expected lifespan?

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#33

Oh sorry, I did misunderstand your post. I thought you were simply afraid to take medicines to help you now incase they didn’t work later, without regards to rapa.

Fwiw, my rapa didn’t alter my labs.

#34

Serum cholesterol level 2.4 mmol/L (92.8 mg/dl)
Serum triglyceride levels 0.61 mmol/L (54.0 mg/dl)
Serum HDL cholesterol level 1.02 mmol/L (39.4 mg/dl)
Calculated LDL cholesterol level 1.1mmol/L (42.5 mg/dl)
Serum cholesterol/HDL ratio 2.4
Serum non HDL cholesterol level 1.4 mmol/L (54.1 mg/dl)

Estimated ApoB from those results is 41

I just don’t see any reason to take a statin/ezetimibe and I don’t know any doctor who would recommend one based on those results. Why take another drug when there is no real benefit?

re. metformin I am young and don’t want to compromise exercise performance. As I get older the cost/benefit may change and I could start depending on TAME trial results.

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#35

Because both metformin and SGLT2 are contraindicated in certain cases of kidney disease, especially if the GFR is lower than 30 or if the patient is prone to dehydration.

#36

I thought SGLT2 inhibitors were recommended for GFR over 20 now. Besides, if your kidneys are that bad already, you’ve already missed the longevity boat. T1 diabetics or those who’ve experienced ketoacidosis are probably the ones who need to take them off the table.

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#37

That’s probably true. T1 diabetics have a life expectancy that’s abbreviated by 10-12 years. People with CKD, especially if they’re on dialysis, also have a significantly shorter life expectancy. In my case, being a fitness buff has already saved my life a few times and may allow me to live about as long as want to live, which is five to eight more years. I’m 77 now. From supplements to peptides to off-label drug use, I’ve gotten far more value from this site than I have from rapamycin.

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