You are probably right. I simply thought having found something that was potentially vaguely relevant I should provide the link, but if it is a rubbish paper then I am happy to delele my post. Alternatively the post can remain, but with your comment and mine remaining as well.

I donā€™t mean to beat this to death, but based on the available evidence I could find, lithium citrate does not appear to be present in or extracted from Garcinia cambogia fruit.
The papers below analyze Garcinia cambogia fruit and its extract but do not mention lithium.
It is improbable that anyone could get significant amounts of lithium from Garcinia cambogia fruit.
I have looked at many papers (because I didnā€™t have anything better to do this morning :slightly_smiling_face:) concerning
Garcinia cambogia. I could not find one that mentioned lithium.
Phytochemical studies have revealed the presence of many elements in Garcinia cambogia, including:
Phenolic compounds
Saponins
Tannins
CaXanthones, such as carbogiol
Benzophenones, such as garcinol
Organic acids, such as HCA
Amino acids, such as gamma aminobutyric acid
Alkaloids
Flavanoids
rbohydrates
Proteins

https://www.sciencedirect.com/science/article/pii/S1878535221000708#:~:text=Among%20macro%20elements%2C%20K%20and%20Ca%20showed,>%20Ni60%2C%20and%20among%20essential%20trace%20elements

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Do you want me to delete the post?

@John_Hemming I think you should delete your post. :slight_smile:

This has now been done. ____________

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@adssx
I think it may be worth experimenting with. I donā€™t think 1-5 mg would hurt. @DeStrider found an immediate upside at 5 mg, while others are more comfortable with 1 mg. @desertshores is a longtime user and advocate. Of all the lithium salts out there, ororate may have the longest half-life, allowing low doses to accumulate in the brain. And it seems to have a significant number of life-enhancing properties. Iā€™ll continue with my routine blood tests, but my physician probably wonā€™t be involved in this experiment.

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This thread has been a fascinating read, thanks to @John_Hemming for starting it!

Leaving aside the mood and mental health benefits for a moment the protection of the brain and specifically dopaminergic neurons is incredibly exciting from a longevity perspective. Loss of dopaminergic neurons is a key limiter on longevity (not just for unlucky Parkinsonā€™s sufferers) and if we can slow that it would be a huge benefit.

EDIT: Was trying to find the original article I read on dopaminergic neuron loss and aging years ago but couldnā€™t! An extract from this was similar though:

https://www.sciencedirect.com/science/article/abs/pii/S0047637499000640

"Dopamine neurons in the substantia nigra of human brains are known to be selectively vulnerable and neuronal loss with advancing age was estimated to be more than one third between the age of 20 and 90 years (McGeer et al., 1988). There is a linear fallout of dopamine neurons with aging at a rate of 5ā€“10% per decade (Fearnley and Lees, 1991), and the limited number of the cells causes dysfunction in cognition and motor movement. "

The point of the article was that since we have this consistant loss of dopaminergic neurons with age if we live long enough all of us will develop Parkinsonā€™s. If you think about all the effort people here go to to avoid CVD (rightly!) there should be equal effort to preserve dopaminergic neurons in order to preserve our cognitive and motor function into old age.

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Thanksz. Any other things with this goal for general dopa/neurological longevity you think we should consider for our playbook?

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can you expand on that? and studies?

Iā€™m far from an expert so take what I say with a grain of salt but a good book on general brain health and nutrition is Brain Food by Lisa Mosconi who is fairly unique in having qualifications in both neuroscience and nutrition. It is non-technical and easy reading with practical advice.

Regarding specific chemicals caffeine appears to have strong protective effects on dopaminergic neurons and appears to help with Parkinsonā€™s also:

Low dose lithium is protective as mentioned here as are anti-inflammatory drugs generally although Iā€™m not saying you should chronically take anti-inflammatory drugs!

There are quite a few drugs in development which I am even further from being qualified to talk about but many drugs developed for preventing or slowing parkinsonā€™s will target the dopaminergic neurons.

There are mixed opinions on rapamycin helping but I have hopes everolimus could have positive effects but I am very much wait and see on thatā€¦

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Some argue low dose selegiline is the way. Iā€™m skeptical.

GLP1RA work but are they pro longevity as they increase insulin? SGLTi and telmisartan seem very promising (see the first paper here for instance: Parkinson's disease - #109 by adssx ). Then of course coffee (and smoking, if you donā€™t mind lung cancerā€¦). There are also papers around glutathione but Iā€™m skeptical and, if true, GlyNAC might do the job better. Many people are hopeful that immunosuppressants/immuno-modulators could work (thereā€™s an ongoing RCT finishing soon). And autophagy enhancere (ongoing trials of Ambroxol, soon Urolithin Aā€¦). See more: Parkinson's disease - #108 by adssx I think thatā€™s all we know so farā€¦ (other than healthy diet, good sleep hygiene, stress management, physical exercise, etc.)

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@Jonas,

See all the papers posted by @adssx.

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Iā€™ve been taking 300 micrograms of lithium chloride drops for a few weeks now and havenā€™t really noticed anything. It should be similar to lithium from other sources like orotate right? I was happy to find 50 microgram drops so I could adjust my dose up slowly and make sure thereā€™s no issues and I didnā€™t want to jump straight to 1 mg which was lowest regular dose I could find.

Is that a measurement of LiCl or elemental Li? li atomic mass is about 1/5 of cl.

Answer:

Following your enquiry for the Life Extension Lithium, we have checked this for UK/EU compliance and unfortunately there is currently no compliance available in the UK, but this is not EU complaint as the ingredients are not authorised in a food supplement.
This is not a product that we will be looking to stock.

I tried to buy some while in Switzerland: couldnā€™t find it either. Iā€™ll keep buying in France thenā€¦

Good state brand marked as serving side 10 drops: Lithium (from lithium chloride) 500mcg

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Sounds like elemental. Yes a really low dose

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@Josh
No, Josh, lithium chloride is not at all similar to lithium ororate or to other lithium salts used to treat bipolar disorder. The chloride is mainly used to produce a metal thatā€™s used to make automotive parts. If I were you, I would stop taking it. Youā€™re lucky youā€™ve been taking only microdoses.

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PQQ seems to boost cognition and memory

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People are apparently selling it as a supplementā€¦ Iā€™m not sure the difference:

If this is what @josh is talking about, Iā€™m not sure this is ā€œLithium Chlorideā€ā€¦