#204

@DeStrider What side effects made you lower your dose? Are they gone or just better on the lower dose. It still is a 12 mg equivalent dose so not that low.

I ask partly because it is always difficult to tell which supplement is causing the effects.

#205

The side effect that made me lower the dose was itchy hives. You can see the pic here. At 6 mg + GFJ, I had over 50 itchy hives all over my torso which appear after dosing and last several days.

At 5 mg + GFJ, I get 5-10 hives and at 4 mg + GFJ, I get 0-1. So, Iā€™m sticking with 4 mg + GFJ. I believe this is my body developing an allergic reaction, because the first few times I dosed at high levels, I did not get hives. However, now it is very reproducible.

I do get hives when I overexpose myself to other things I am allergic to such as animal dander. So Iā€™m pretty sure itā€™s allergic in nature.

4 Likes
#206

Thank you very much for the information. What do you mean by high dose rapamycin? What dosage?
Laura.

#207

Could I enroll in your study?

Thanks. Laura

#208

What do you mean by taking high dosage? What dosage of rapamycin you are taking. Thanks. Laura

#209

This is the scale I use for weekly doses:

1-4 mg a week - low dose.
5-9 mg a week - average dose
10+ mg a week - high dose

I personally take 14 mg a week (4 mg + GFJ + EVOO) but have gone up to 21 mg a week at my highest.

@John_Hemming takes ultra-high doses very infrequently (60 mg+)

4 Likes
#210

My current (ultra?) high dose is 22mg plus GFJ. A rule of thumb multiplies that by 3.5 for bioavailability. (-> 77mg) I am currently waiting for my WBC to be reliably above 2G before taking my next dose. I do blood tests weekly so I will know this soon.

I have posted glucose charts and blood work from one of my doses.

5 Likes
#211

What made you decide to stick on a weekly dose rather than extend to around 14 days like a lot of people who take a higher dose?

#212

My body can still only take 4 mg + GFJ before developing side effects whether it is every week or two weeks. So, Iā€™d prefer to dose more often, although that does mean thereā€™s always at least 1 mg of Rapamycin in my system while dosing. I do take a break every 3rd week to clear the Rapa out. So essentially Iā€™m on for 2 weeks and off for one. Itā€™s almost an every other week schedule.

5 Likes
#213

@John_Hemming , are you still taking (or did you resume taking) these high doses, if you donā€™t mind me asking, and did you happen to post an update on your blood work anywhere?

2 Likes
#214

I am still taking infrequent ultra high doses, but have not posted the details of my blood tests. I donā€™t think, however, that they are significantly different such that were I to post them you would find new information. I am running other experiments as well.

4 Likes
#215

What is the highest dose youā€™re currently considering trying?

#216

I am not currently saying this publicly. I am very careful with testing as I do weekly blood tests and monitor a lot of things. I am not sure my dosing as above or currently would be safe for other people.

2 Likes
#217

Iā€™m planning on starting at a low dose. I hopefully am starting rapa soon.

#218

Thanks John, sorry if you mentioned anywhere, but do you take a statin/Ezetimibe or any other hypolipidemic agents?

#219

Not other than berberine and intermittent alcohol

2 Likes