"Lock In" Rapamycin Gains with Higher Doses

[Maxi]

No, I take only blood pressure medications and muscle relaxants/pain killer because of my chronic deseases (ME/CFS,IBD). I am just starting Rapa 6mg/week in the hope it helps.

[59vw]

@DeStrider What side effects made you lower your dose? Are they gone or just better on the lower dose. It still is a 12 mg equivalent dose so not that low.

I ask partly because it is always difficult to tell which supplement is causing the effects.

[DeStrider]

The side effect that made me lower the dose was itchy hives. You can see the pic here. At 6 mg + GFJ, I had over 50 itchy hives all over my torso which appear after dosing and last several days.

At 5 mg + GFJ, I get 5-10 hives and at 4 mg + GFJ, I get 0-1. So, I’m sticking with 4 mg + GFJ. I believe this is my body developing an allergic reaction, because the first few times I dosed at high levels, I did not get hives. However, now it is very reproducible.

I do get hives when I overexpose myself to other things I am allergic to such as animal dander. So I’m pretty sure it’s allergic in nature.

Side Effects of Rapamycin (part 2)

It is bilateral. I found a couple on my upper thigh that were not red or inflamed but still itchy and harder than the surrounding skin. Even long after a shower the torso ones are still red. The photo I posted was after a shower which was when I noticed them in the mirror. This pic is after the Claritin and 1-2 hours. They are mildly to moderately itchy. The bigger the itchier. If you asked me to guess without counting how many there were before I counted, I would have said about 5. [IMG_20240730_095604]

[Lewei]

@DeStrider

Mikhail Blagosklonny

Thank you very much for the information. What do you mean by high dose rapamycin? What dosage?
Laura.

[Lewei]

Could I enroll in your study?

Thanks. Laura

[Lewei]

What do you mean by taking high dosage? What dosage of rapamycin you are taking. Thanks. Laura

[DeStrider]

This is the scale I use for weekly doses:

1-4 mg a week - low dose.
5-9 mg a week - average dose
10+ mg a week - high dose

I personally take 14 mg a week (4 mg + GFJ + EVOO) but have gone up to 21 mg a week at my highest.

@John_Hemming takes ultra-high doses very infrequently (60 mg+)

[John_Hemming]

My current (ultra?) high dose is 22mg plus GFJ. A rule of thumb multiplies that by 3.5 for bioavailability. (-> 77mg) I am currently waiting for my WBC to be reliably above 2G before taking my next dose. I do blood tests weekly so I will know this soon.

I have posted glucose charts and blood work from one of my doses.

[BeatTheOdds]

What made you decide to stick on a weekly dose rather than extend to around 14 days like a lot of people who take a higher dose?

[DeStrider]

My body can still only take 4 mg + GFJ before developing side effects whether it is every week or two weeks. So, I’d prefer to dose more often, although that does mean there’s always at least 1 mg of Rapamycin in my system while dosing. I do take a break every 3rd week to clear the Rapa out. So essentially I’m on for 2 weeks and off for one. It’s almost an every other week schedule.