#81

Hi I’m having a little trouble navigating this site but to RapAdmin thanks for reply. Since my lipid levels already run a bit high, esp LDL at 150 or so, and am not on statins due to other markers, will definitely get this checked soon. I’ve seen something about insulin levels too? I’ve only had fasting glucose and A1C done. What exactly would I ask for, just an insulin level? Can it be done with a standard blood draw or are they talking about the glucose tolerance test? Are there any other out of the standard blood tests I should ask for or are sugar and lipids the main ones? Thanks!

#82

Thanks Kerstin what is GF and do you take metformin and the statin because the Rapa increased your blood values? I think if my levels are off I won’t stick with it if it doesn’t make me feel better because I don’t want to live longer with this chronic fatigue.

#83

Hi RapAdmin I see the right reply button now think I sent the other so that it’s imbedded somewhere among others. Sorry just getting used to this.

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#84

My two little dogs, 4lbs and 6 lbs, both on Rapa, just recently died. One was 19 years old and another one 10 (a rescue with many health problems). Both died from stroke. They had rather high dose of Rapa (0.5 mg) per their weight, given intermittently (once every 2 weeks). I couldn’t divide the coated pill for them. Ideally I would want to give them less.

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#85

My mom is the same age and weighs 135lbs. I built her up from 1mg on the first week, 2mg second week… to a 6mg every 1.5-2 weeks just to be sure we’re not affecting mTORC2. She seems to be doing great on it and I see such a huge improvement in her overall fatigue, physical resillience and overall health. She’s already on her second year of taking rapa and really never had a washout period. Now she alternates between 5mg to 6mg. But she did have breast cancer and it seems to be keeping it in check. I would say if your bloodwork looks great and you feel good, then I think there is no need to change anything. It is very possible that the older the age, the higher the dose is needed.

Just please get general bloodwork done (CBC, CMP …) after a few weeks on rapa to have a basic picture of what’s going on inside. There’s no way to track its’ effect on your bloodwork if there’s nothing to compare the bloodwork to.

@RapAdmin I’m curious if women can tolerate a larger dose without much side effects compared to men? Would there be any data on that? Or do women generally require a bit larger dose for rapa?

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#86

What higher doses increased the inflammation for you? If you’re taking the rapa with GFJ for the high dose, it could be that we really don’t know how high a dosage you’re taking as it changes everytime and that’s where it becomes a bit tricky to keep track off.

For the lower dose: how often did you take the 6mg ? Weekly or every 2 weeks?
Maybe instead of 4mg weekly, try the 6mg every 1.5 - 2 weeks. I would be curious to see which scenario would lead to better bloodwork. Lower dose but more frequent dosing or slightly larger dose buta bit larger intervals?

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#87

Hey TFL…
My high doses were 8 mg with GFJ… was getting a 38 ng/mL.

Because I was actually doing a trough blood draw. At zero, and then doing a second blood draw two hours after my dose, I was very aware of what the grapefruit juice was doing with the rapamycin.

In looking at it, that’s not a crazy high-dose, but it was enough to throw off my biological markers both in glycans and methylation tests.

Prior to that, it was strictly 6 mg once a week. I would like to see what 4 mg once a week would do now that I’ve been on rapamycin for almost four years.

No I don’t want to take a higher dose even even over a longer period of time.

That’s the problem. The big dose, it’s either too high, too low… or just right.

4 mg weekly for next 6 months and retest biomarkers.

Will markers go up - faster aging? Will they go down - slower aging? Will they stay the same… 4-6 mg no difference.

Without clinical trials, all we can do is experiment on ourselves. And even in the clinical trials, there are different phenotypes and genetic types of people. So even then, one size might not fit all.

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#88

Thanks please keep us posted.

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#89

Show me any mammal studies that show more is worse!

Of all of the “gurus” out there, you must pick one to follow for the dose, frequency, and delivery that you think is best for you. I choose to follow one of the pioneers.

Mikhail (Misha) V. Blagosklonny graduated with an MD and PhD from First Pavlov State Medical University of St. Petersburg, Russia. Dr. Mikhail V. Blagosklonny subsequently relocated to the United States, where he was awarded the prestigious Fogarty Fellowship from the National Institutes of Health. During his fellowship in Leonard Neckers’ laboratory at the National Cancer Institute (NCI), he was a co-author of 18 publications on diverse biomedical topics, including targeting HSP90, p53, Bcl2, Erb2, and Raf-1. He also was the last author on a clinical phase I/II trial paper.

Professor of Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York

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The higher the dose, the longer lifespan.

“in humans therefore the highest acceptable dose that does not yet cause unacceptable side effects may be optimal for longevity”

Dr. Blagosklonny was taking rapamycin before he discovered he had cancer. of course he was smoking at the same time he was taking rapamycin.

My present dose is 5 mg with GFJ juice weekly. Some consider this a high dose but I don’t because it causes me no adverse side effects. After a while he came to the guess that maybe once a week dosing is best. When I first started with rapamycin, I was taking 20 mgs with GFJ. Other than diarrhea, I experienced no serious side effects, but I did lose all of my arthritic pain among other things.

At 5mg with GFJ weekly and a few drugs, metformin, bempedoic acid, etc. all markers that I have measured are excellent.

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Interview with Mikhail Blagosklonny.

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#90

Thanks I am realizing I just started this knowing nothing about it, eg have no idea what MTorC2 is. I just read about the guy with fatigue on Health Rising, and did read a book called Rapamycin, but it didn’t go into any of the stuff all of you are talking about. I don’t want to get into it like a lot of folks here with the frequent blood tests (doubt doc would order them anyway) but will get the basic ones done soon. Thanks.

#91

Desertshores you are well past me in years, so more might not have an effect on you - might even be good.

But for me, more is detrimental. I am shooting for a hundred years while looking 60 years. We have very different goals in rapamycin use. That ship has sailed for you my friend. You look good for your age. I want looking good not related to my age. LOL. I wish I had started at 50 years.

My tests taken today: DEXA and Coronary Calcium Scan say I am spot on in arresting age to a degree. Two years have passed and no change in muscle or fat. Heart still that of under 35 years. The woman who did my scans today (and did it two years ago too) told me this is not typical with several years – changes always come. I have not budged.

My Researcher of choice is Matt Kaeberlein.
From Matt Kaeberlein, PhD private message to me in November 23.
Re: Rapamycin higher dose - Matt wrote: "I honestly don’t know. I understand Misha’s (Mikhail Blagosklonny) rationale for pushing it as high as possible until you get to side effects. My concern there is that you might be getting to side effects and not know it right away or at all (silent pathology) until it’s too late to reverse the damage. I have no evidence for that, but it’s a concern I have.

I absolutely think it’s possible that 36 ng/mL could be net detrimental to health while 6-8 mg could be beneficial. I am certain the optimal dose will be different for different people." Kaeberlein 2023

By the way Matt Kaberlein does 8 mg rapamycin weekly no GFJ – he tests at 20-22 ng/mL. 2 hours after dosing.

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#92

A potentially dangerous attitude to take. And the expert you choose to follow has cancer?

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#93

Mikhail Blagosklonny does have cancer because he was an avid smoker. The fact is that the experts are guessing just as we are. They read the same material that we do. Some are more cautious than others. I like Dr. B and Dr. Kaberlein, although I prefer Dr. Kaberlein more. However, even he goes back and forth between high and low doses. I’ve noticed that he tends to be more cautious (low doses) when speaking to individuals and more aggressive (high doses) when speaking theoretically with researchers. I can see both points as being valid.

However, I do believe that the animal data is telling us that high doses are very effective. Unfortunately, we don’t have animal data telling us the effectiveness of low doses. What we need is a study that fills that gap. Until we do, I think I need to do a period of high dose and mitigate the side effects with Metformin, Bempedoic Acid, Empagliflozin, Acarbose, etc…

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#94

We don’t know if it was a cause or the only cause of his cancer. Would be nice to know. What if overdosing on Rapa for years created favorable conditions for cancer development?

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#95

Rapamycin is a chemotherapy agent that slows tumor growth. It’s used in conjunction with many other chemotherapies to enhance their cancer-killing effects. Somehow, I really doubt it would cause cancer. It’s FDA approved to treat some forms of cancer.

I’ll put my money on the daily smokes.

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#96

Thank goodness someone close to my dosing. Everyone here seems to take so much. I started about 4 months ago w 2mg every week (recommended dosage Dr. Green). I am used to it now and its ok. I squeezed some grapefruits and drank juice about an hour before dosing. It was Ok day one, tired day 2. I haven’t heard about combining with fasting. Could you explain more about that approach?

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#97

@Thor1 Others have looked harder into the science of rapa and of fasting, and how to combine them for benefit. Do a search on this forum for a ton of discussion. Here is a link to a useful post

For me it comes down to convenience. I want to do one 24 hour fast (including all drugs and supplements) every week. I also want to take rapamycin. Both interfere with my physical activity so doing them together lowers the lost time. I hate doing both so together lowers the time in misery. Also, I want the rapa to clear quickly so I want an empty stomach, so that fits. I eat grapefruit before I take Rapa, so that’s not exactly fasting but im not fanatical about it. Maybe there is a combination benefit, but some people here don’t think so.

I try not to be a slave to my longevity efforts. I try to emphasize things that I enjoy (or can learn to enjoy) that also make me healthy. Repetition and reward make a habit.

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#98

This very close to my sentiments and how I approach overall health. Thank you!

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#99

If you chew a couple acarbose before the grapefruit your gut buddies will get the sugar from the grapefruit, and acarbose is supposed to increase MTor2. Just an idea.

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#100

A few years ago I overdosed on Rapa which resulted in temporary lung scarring. It was resolved though after I stopped Rapa for 4 months and then restarted on a much smaller dose. Dose is everything. Rapa is known to detrimentally affect healthy lungs. My point is that lungs of a smoker could be affected even more.

Rapamycin is used to treat certain lung conditions like lymphangioleiomyomatosis (LAM), where it helps reduce the loss of lung function¹. However, it can also cause some serious side effects, including:

  • Pulmonary fibrosis (lung scarring and stiffening)
  • Pneumonitis (lung inflammation)

Source: Conversation with Copilot, 6/26/2024
(1) Lung function response and side effects to rapamycin for … - Thorax. Lung function response and side effects to rapamycin for lymphangioleiomyomatosis: a prospective national cohort study | Thorax.
(2) Rapamune Side Effects: Common, Severe, Long Term - Drugs.com. Rapamune Side Effects: Common, Severe, Long Term.

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