KarlT
#5
What about that expert Krister Kauppi?
5 Likes
RPS
#6
Yeah, he’s definitely a “longevity leader”
Come to think of it, so is @RapAdmin
And that guy who does the Wise Athletes podcast!
5 Likes
Interestingly the least frequent is every 2 weeks. I am sticking with every 21 days.
2 Likes
I want to know (a) how old are they, and (b) how long have they been doing their regimen? Bryan Johnson is 46 and has been doing his crazy stuff for a relatively short time. Get back to me in 30 years and if he’s still going strong, then I’ll consider him a “longevity leader”.
5 Likes
I do every two weeks and take a week off every 5th week. I’d go for 3 weeks if I dared take a bigger dose.
5 Likes
@KarlT Big thanks! There are quite many new people which I will add to the next version. Will see if I can add me in somehow 
@RPS Great suggestions!
@John_Hemming What dose do you take every 21 day?
@Dexter_Scott I like the suggestion and I had the plan to add that and also weight but it got a bit too personal which made it hard to get people to the list. Maybe I can add that as a parameter later on but most people on the list is around 45-65 years old.
@Joseph_Lavelle What dose regime are you currently on, Joe?
2 Likes
6mg with either part of a Pomelo or part of a Grapefruit. Zydus and Biocon sirolimus (I alternate supplier).
Apart from disrupted sleep (the first night and possibly the second) I have not identified negative side effects.
2 Likes
AnUser
#12
If a bunch of random names that aren’t ‘longevity leaders’ are added, the list will become useless, although we should appreciate people being nice in that way and all.
4 Likes
4mg 1x/14 days. I eat a grapefruit 3 hours before and with rapa. Other than the grapefruit I do not eat for 12 hours before rapa and 24 hours after rapa. I estimate an equivalent 12mg but I haven’t tested it.
After 2 doses I take off a week. Every year I take off a month (skip 2 doses). So I take about 18-19 doses a year.
1 Like
I’ll know that I’ve hit the big time when I make next year’s list!
9 Likes
Interestingly, female leaders take significantly less than male leaders, I didn’t do the math on this but it seems that this goes beyond simple per weight dosing.
3 Likes
Yes - it did seem a little less - and I don’t know the weight of these ladies or men. My wife weighs about 75% of my weight so she gets about 75% of my dose - this is based on lean body mass. It makes sense - but it does seem like they are going at it much more cautiously.
3 Likes
Reason #1396 why women live longer 
6 Likes
Doses taken with Grapefruit/Pomelo have a material multiplier effect. Hence I am taking possibly over 18mg every 21 days, With a half life of just under 3 days it means a week above 4.5mg. It may be over time that I should reduce the frequency of taking Rapamycin. It (probably) has taken my HbA1c up to 5% in a test done today that I received today (joy!) I took R on 12/4. It is difficult to be precise on HbA1c because some labs delay in testing. It may be I should have a cycle of a month of immediate test results, but in the end I am working on a broader pattern.
3 Likes
I only take 3 mg a week because of the fear of increasing my glucose
3 Likes
I did wear a CGM whilst taking rapamycin and it did seem to have an effect. I find wearing a CGM a bit of a nuisance as I have to be careful not to knock it off my arm. I saw an advert recently for a smart watch that monitors glucose. That would be nice, but the one I tried from China (E500) made up the results.
I think some day that will be possible. However, I had 6 mg of rapamycin with Grapefruit on 12th April and on 24th April my 1.75 hours post prandial non-fasting glucose was 4.1 mmol/L (which I think is about 73.8 in US units).
On the other hand I think my HbA1c had been pushed up a tad.
The reason I dose infrequently is to balance out the side effects and keep mTOR functioning normally hopefully most of the days in the dosing cycle.
1 Like
Jonas
#21
Two things: the video is why TSLA is up today, and more importantly I want to know what Ron Baron’s is on as he sure looks great for an 81 yr old:
@RapAdmin any ideas?
IMO: Most people are overly worried about the slightly increased glucose levels associated with taking rapamycin.
Once again we see the ubiquitous J or U-shaped curve associated with HbA1c levels.
My takeaway from this is that there may be some benefit from a lower HbA1c but there is little actual risk from a little higher HbA1c.
The study included 3,154 critically ill patients without diabetes who had HbA1c measurements in the database.
"1-year mortality, while levels between 5.0% and 6.5% of HbA1c did not significantly affect these outcomes.’
“Spline models revealed a U-shaped association, with lowest risk at HbA1c levels 5.4-5.6% (36-38 mmol/mol) and a significantly increased risk at ≤5.0% (≤31 mmol/mol) and ≥6.4% (≥46 mmol/mol).”
“The association between hemoglobin A1c and all-cause mortality in the ICU: A cross-section study based on MIMIC-IV 2.0 - PMC”
“Association Between Hemoglobin A1c and All-Cause Mortality: Results of the Mortality Follow-up of the German National Health Interview and Examination Survey 1998 | Diabetes Care | American Diabetes Association”
“The HbA1c and All-Cause Mortality Relationship in Patients with Type 2 Diabetes is J-Shaped: A Meta-Analysis of Observational Studies - PMC”
Of course, we do not have as yet any studies indicating any increased risk of diabetes in non-kidney transplant healthy people. However, we do have studies indicating that there was not an increased risk in kidney transplant patients who were taking higher continuous doses than members of the forum are taking.
“The systematic review and meta-analysis provided in the context does not provide evidence that converting to rapamycin increases the risk of new onset diabetes after kidney transplantation. The study compared rapamycin to calcineurin inhibitors and found no difference in diabetes risk between the two groups. More research may be needed specifically examining the diabetes risk of rapamycin compared to placebo or no treatment.”
“Conversion From Calcineurin Inhibitors to Mammalian Target of Rapamycin Inhibitors in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - PMC”
3 Likes
I’d guess his stack includes a sunlamp or he lives on a boat. I’m jealous!
1 Like
Neo
#24
Charles, it seems to be that these are associations studies and diseases like cancer push HbA1c down and hence contribute to correlation between low HbA1c and mortality even if the causation is cancer => low mortality AND low HbA1c
and not low HbA1c => Cancer and Low mortality
See eg here
3 Likes
