#21

Great list and something i haven’t heard of … citrulline.

Funny you mentioned Amla because I was taking it for several years, and it was just this very week my doc told me I might not be getting benefit so I could skip it. I took it off my list before posting :).

Curious if you see a difference with it, or like me, are you taking it in the hopes it does. I’d really just continue to take it just incase, but my list is ridiculous at this point, so I was happy to delete it!

I forgot to add I recently started taking creatine too!

PS, I’ll add rapamycin made the biggest difference for me. I’ve mentioned elsewhere that it changed me from a lifelong insomniac to a sleeper. Some of these other things, like taurine and ldn, have also helped my sleep.

3 Likes
#22

I’m building a site to track people’s stacks to enable discovery and summarization (it’s my retirement hobby). Ideally, people from sites like this would contribute their stacks for everyone’s benefit. Site is about 2 weeks from being “finished” but I’m starting to seed it with 100 stacks I’ve researched of different longevity doctors, influencers, etc… You can see the work in progress here: (https://wellstackedlife.com/). Shout out to @adssx who was one of my early testers!

6 Likes
#23

I’m not sure I agree with the ranking of compounds but her tenets seem sound and quite close to @John_Hemming 's theory of aging.

1 Like
#24

So why Pterostilbine but not Resveratrol?

#25

I wouldn’t touch either Resveratrol or Pterostilbine. Both are rubbish IMHO.

4 Likes
#26

I am quite happy with Pterostilbene, but Resveratrol is a cyclooxygenase-1 (cox-1) inhibitor and therefore prevents the creation of prostaglandins.

2 Likes
#27

My thoughts:

  • I had to stop listening when she started talking about Resverstrol and surtuins. I read the AI notes others posted above to get the rest of the video summary.

  • Are we really still doing the Rapamycin immune suppression thing? I thought we pretty much established that’s only for daily or more frequent users.

  • I always knew her as the “Metformin is the holy grail” doctor. The show notes make it seem like she didn’t bring it up in this video. I wonder if she still thinks highly of it.

  • I respect her opinions but I think she overrates a lot of these things, mostly focusing on positive conclusions and disregarding negative ones.

2 Likes
#28

Pterostilbene is more bioavailable.

Resveratrol or Pterostilbene? A review of two promising stilbenes - CIRCE Scientific.

The three hydroxyl groups in resveratrol hasten the molecule’s removal, which makes it challenging to reach and maintain appreciable levels of resveratrol in the bloodstream.

In pterostilbene the other two hydroxyl groups are replaced by methoxy groups (O-CH3). This difference is crucial** because it influences how quickly the compound is metabolized and eliminated from the body.**

Due to its structural characteristic, pterostilbene is more lipophilic, exhibits better bioavailability, and is more biologically active than resveratrol.**

1 Like
#29

Do you have any basis for that assertion? Or is this guilt by association - association with David Sinclair?

#30

I like Sinclair. However, I don’t like Resveratrol. Pterostilbine is guilty for being a Resveratrol mimetic.

Personally, Resveratrol gave me GI issues. I’ve also read many articles which question it’s value and that it may actually cause harm. I dumped my remaining Resveratrol about a month ago.

Here’s Dr. Stanfield’s opinion:

3 Likes