cl-user
#2
The full paper would be nice. In the mean time we can at least look at some of the figures. That one is very interesting as it list a bunch biomarkers:
5 Likes
cl-user
#3
Here are the reference ranges they used it seems.
They have published the normalization code on GitHub
| short_name |
low_male |
high_male |
low_female |
high_female |
| WBC |
4.4 |
11 |
4.4 |
11 |
| RBC |
4.5 |
5.9 |
4.1 |
5.1 |
| Hemoglobin |
14 |
18 |
12 |
16 |
| Hematocrit |
42 |
50 |
37 |
47 |
| Platelets |
150 |
450 |
150 |
450 |
| MCV |
80 |
96 |
80 |
96 |
| MCH |
28 |
33 |
28 |
33 |
| MCHC |
33 |
36 |
33 |
36 |
| RDW |
12 |
15 |
12 |
15 |
| MPV |
9 |
10 |
9 |
10 |
| Albumin |
3.5 |
5.5 |
3.5 |
5.5 |
| Total Cholesterol |
NA |
200 |
NA |
200 |
| Triglycerides |
NA |
150 |
NA |
150 |
| Iron |
50 |
150 |
50 |
150 |
| Transferrin |
200 |
400 |
200 |
400 |
| Ferritin |
24 |
336 |
11 |
307 |
| Total Globulin |
2 |
3.5 |
2 |
3.5 |
| Fibrinogen |
200 |
400 |
200 |
400 |
| Lymphocytes, Abs |
1 |
4 |
1 |
4 |
| Lymphocytes, % |
30 |
45 |
30 |
45 |
| Neutrophils, Abs |
2 |
8.25 |
2 |
8.25 |
| Neutrophils, % |
50 |
70 |
50 |
70 |
| Monocytes, % |
0 |
6 |
0 |
6 |
| Eosinophils, Abs |
0 |
0.5 |
0 |
0.5 |
| Eosinophils, % |
0 |
3 |
0 |
3 |
| Basophils, % |
0 |
1 |
0 |
1 |
| Glucose |
70 |
99 |
70 |
99 |
| Urea |
7 |
28 |
7 |
28 |
| Creatinine |
0.7 |
1.3 |
0.5 |
1.1 |
| Uric Acid |
3 |
7 |
3 |
7 |
| Calcium |
8.6 |
10.2 |
8.6 |
10.2 |
| Phosphorus |
3 |
4.5 |
3 |
4.5 |
| Total Protein |
5.5 |
9 |
5.5 |
9 |
| HDL Cholesterol |
NA |
40 |
NA |
50 |
| LDL Cholesterol |
NA |
100 |
NA |
100 |
| Alk. Phosphatase |
30 |
120 |
30 |
120 |
| AST |
10 |
40 |
10 |
40 |
| ALT |
10 |
40 |
10 |
40 |
| GGT |
9 |
50 |
8 |
40 |
| LDH |
105 |
333 |
105 |
333 |
| CPK |
55 |
170 |
30 |
135 |
| Total Bilirubin |
0.3 |
1 |
0.3 |
1 |
| Direct Bilirubin |
0.1 |
0.3 |
0.1 |
0.3 |
| Hemoglobin A1c |
4 |
5.6 |
4 |
5.6 |
| Sodium |
136 |
145 |
136 |
145 |
| Potassium |
3.5 |
5 |
3.5 |
5 |
| Vitamin D (25-OH) |
30 |
60 |
30 |
60 |
| Microalbumin:Creatinine |
NA |
30 |
NA |
30 |
| TSH |
0.5 |
4 |
0.5 |
4 |
| T3, Free |
3.5 |
6.5 |
3.5 |
6.5 |
| T4, Free |
10.3 |
23.2 |
10.3 |
23.2 |
| Blood Pressure, Systolic |
NA |
130 |
NA |
130 |
| Urine Specific Gravity |
1.002 |
1.03 |
1.002 |
1.03 |
| Urine pH |
4.5 |
8 |
4.5 |
8 |
| PT, INR |
0.8 |
1.2 |
0.8 |
1.2 |
| Vitamin B12 |
200 |
800 |
200 |
800 |
| PSA |
0 |
3.5 |
0 |
3.5 |
| ESR |
0 |
15 |
0 |
20 |
| aPTT, sec |
25 |
35 |
25 |
35 |
| CRP |
NA |
0.8 |
NA |
0.8 |
| Amylase |
25 |
125 |
25 |
125 |
| Folic Acid |
4.1 |
20.4 |
4.1 |
20.4 |
| Magnesium |
1.2 |
2.6 |
1.2 |
2.6 |
| Indirect Bilirubin |
0.2 |
0.7 |
0.2 |
0.7 |
| LH |
2 |
9 |
NA |
NA |
| Estradiol |
73.4 |
184 |
36.7 |
660 |
6 Likes
Here’s another interesting study which I can access.
A new study shows that bodily organs get “older” at extraordinarily different rates, and each one’s biological age can be at odds with a person’s age on paper
5 Likes
EnrQay
#5
I look forward to a commercial lab test based on proteomics. Current lab tests are crude and only partly organ-focused.
1 Like
This is a similar full-access article. It verifies that the Levine test is a good predictor. Also. it shows that cystatin-C is the most important aging biomarker: (other than age and sex)
BTW: I have never had a cystatin C test. I guess I will have to add it to my blood work in the future.
As an aside: Rapamycin raises fasting glucose levels. IMO: unless you are diabetic, we probably are wasting too much time obsessing about glucose levels. Important maybe, but not as important as many other markers. I noticed early on that glucose was not heavily weighted on the Levine spreadsheet calculator.
“Patients with Type 1 DM and with Type 2 DM are expected to have an average life of 70.96 and 75.19 years at the end of observed period. The combined diabetic life expectancy is 74.64 years—comparable to the life expectancy in the general population”
Full access article:
https://www.nature.com/articles/s42003-023-05456-z
Life expectancy and survival analysis of patients with diabetes compared to the non diabetic population in Bulgaria - PMC.
6 Likes
This is very interesting. Thanks.
I’m confused by the “high levels of creatinine, alanine aminotransferase and vitamin-D are associated with lower hazard rates”. Isn’t high creatinine indicative of kidney problems, just like high cystatin-c?
My creatinine is high (I think due to muscle mass) while my cystatin-c is good.
1 Like
Glucose. I worry a lot about glucose. Perhaps I shouldn’t. My understanding is that high glucose causes many bad things to happen. But “lower is better” almost certainly isn’t true, as anyone who has experienced low blood sugar can attest.
But do these data say that getting my HbA1c to 5.0 isn’t important even if possible? I have brought my HbA1c down from 5.8 to 5.5 despite adding rapa bit only through many efforts. I’m not sure what else I could do to bring it down further. I keep thinking it is progressive…will go up over time, so I need to get low and fighting off any increases.
It is confusing.
cl-user
#9
Very low blood glucose is OK if you are running on ketones instead.
That said I’m running on ketones, eating low carbs and my blood glucose is still too high.
BTW Looking at the chart I posted above, high creatine is better until the 70’s where there is a peak at 0 (People in the high mortality track) so I guess that’s where the people with kidney problems are.
1 Like
What is your eGFR telling you? It has always been my understanding that this is the most used test for kidney health.
I don’t pay much attention to my creatinine levels as long as they are within accepted norms, because this is another measure that varies too much in my results depending on my level of exercise creatinine intake etc.
eGFR is considered a mostly reliable test for doctors to know how well your kidneys are working. However, the eGFR may not be accurate if you are younger than 18, pregnant, very overweight or very muscular.
Blood test: eGFR (estimated glomerular filtration rate) | American Kidney Fund.
1 Like
Perhaps we are placing too much weight on glucose control. Other than the obvious, people with diabetes need to be treated. Even then, when we just consider type 2 diabetes and glucose control in normal humans, there is no evidence that I have found that indicates that tight glucose control in other than type 1 diabetics extends either health span or lifespan. I am happy to change my mind. I would think that tight glucose control in healthy subjects extends health span, but there is very little evidence for that either.
Of course, a big driver for glucose control comes from big pharma. They make billions off of glucose control.
Before anyone challenges me, I said “tight” glucose control. Of course, if you eat a lot of sugar and high glycemic foods you will have other health problems besides glucose control.
2 Likes
@desertshores. My cystatin-c is 0.75 mg/l. The online calculator says my eGFR is 108 mL/min/1.73m2
My creatinine is 1.33 mg/dl which the high end of the normal range.
@cl-user How do I interpret this chart? it looks interesting but I don’t know how to find myself on it. Thanks.
Neo
#14
Perhaps this? Discussed elsewhere on the Forum. Top Stanford prof behind it.
1 Like
Neo
#15
I wonder if you just explained it - a younger phenotype has more muscle and even if kidneys are functioning that might drive that populations levels creatinine levels up…
2 Likes
Neo
#16
@desertshorese:
Yes, I really do too, partially because of glucose and all the related glycation forms of damage and age acceleration
And because of it being a proxy for what is happening with insulin levels and variance… insulin seems to be like one of the anti-longevity culprits via growth signaling along the lines of mTOR and IGF-1, etc
We also have all the ITP and other animal studies constantly showing that glucose modulating therapies extent life span
Glucose is also low and generally more controlled in fasting, intermittent fasting and CR
While I don’t agree with aspects of keto like the cardiovascular risks, it does support health benefits to low glucose, perhaps including neuro protection
And then we have the fact that glucose seems to be one of the few levers we can pull and control today as part of a decrease risk of cancer strategy
Blue zones, seems also to generally have complex carbs, when carbs and mixed with healthy fats and protein to lower glucose spikes
Did you see thread and discussion of Pendulum?
My glucose is generally low and HbA1c always comes in low so far, but I think I’m going to try it to lower my spikes and variability (and for all of the other gut / microbiome improvement reasons)
2 Likes
As I said, creatinine levels vary a lot. Since you are younger and fitter than I am, I would say maybe your physical activity is driving it up. So next time you test maybe lay off for a few days before your blood tests if your creatinine levels are worrisome to you.
I personally just pay attention to my eGFR levels for kidney function.
2 Likes
Creatinine also metabolises in blood samples.
Bicep
#19
It looks like this model is better and I’d like to use it, but the units are strange and I don’t get several of the tests done. Also they ask for the log of several of the parameters:
It would be nice if it was in an excel spreadsheet like the other one.
2 Likes
Tim
#20
@desertshores, GFR and creatinine are basically the inverse of each other. The kidneys are the body’s filter, removing wastes by way of the urine. Your GFR is the rate of filtration, so you want that high. The equation for it takes age, gender, weight, and other factors into consideration. Creatinine is one of the waste products, so you want that to be low or at least in normal range. Creatinine is derived from the action of the muscles. Oddly, some departments of the hospital use GFR as their primary metric, while others, like urology, use creatinine. My neph uses both.
