Magnesium Recommendations

John_Hemming · 2023-05-04T06:20:34.112Z

That sort of comment from the manufacturer makes me worry about their chemistry.

en.wikipedia.org

Salt (chemistry)

In chemistry, a salt is a chemical compound consisting of an ionic assembly of positively charged cations and negatively charged anions, which results in a compound with no net electric charge. A common example is table salt, with positively charged sodium ions and negatively charged chloride ions. The component ions in a salt compound can be either inorganic, such as chloride (Cl−), or organic, such as acetate (CH3COO−). Each ion can be either monatomic, such as fluoride (F−), or polyatomic, su...

DeStrider · 2025-01-23T03:39:40.619Z

FYI, just be careful about how much magnesium you take. I used to take magnesium citrate which was fine. But then I added an SGLT2i and that increased my serum magnesium and now I am showing the symptoms of magnesium overdose (facial flushing, urine retention, dehydration, headache, muscle weakness). I had thought it was the empagliflozin, and I am somewhat right, but it is due to too much magnesium caused by the empagliflozin. I’m cutting all magnesium supplementation and hoping my body quickly returns to equilibrium.

Davin8r · 2025-01-23T04:07:49.855Z

@DeStrider did you have your serum or RBC magnesium tested? Mine is in the normal range even though I’ve been on daily 25mg empagliflozin and magnesium taurate (375 mg elemental Mg) for well over a year now.

DeStrider · 2025-01-23T04:12:29.345Z

I take about 430 mg supplemental magnesium plus empagliflozin. I also eat a diet rich in magnesium (lots of soy, leafy vegetables, fruit and nuts). So this is an educated guess based on my part as the symptoms of too much magnesium appeared after starting empagliflozin. I’ll need to get more blood work to find out for sure.

All of this combined is probably pushing me way over the limit. Hypermagnesia is a rare side effect of SGLT2is but it is possible.

See:

SGLT2Is May Increase Serum Magnesium 10-30%

FYI. Unlike lithium and sodium, magnesium levels in the blood are actually increased by SGLT2i. I may be overdosing magnesium as I have overlooked this factor until now! SGLT2 inhibitors have emerged as potential treatment options for hypomagnesemia in patients with type 2 diabetes. Data analysis performed on randomized controlled trials has demonstrated increased serum magnesium levels with SGLT2 inhibitors as a class effect in patients with type 2 diabetes compared with placebo. Empagliflozin (25 mg) appears to reduce Magnesium excretion in urine by 50%. It appears to have no effect on potassium, calcium, albumin, or creatinine. [image]

John_Hemming · 2025-01-23T07:34:03.739Z

I take a lot of Magnesium (at times a gram a day), but test my blood weekly and the serum level is normal.

DeStrider · 2025-01-23T07:49:48.705Z

Do you take an SGLT2I as well?

John_Hemming · 2025-01-23T10:03:37.544Z

No I don’t take an SGLT2i

LukeMV · 2025-01-23T13:52:09.925Z

Same as me. A bit under 1g plus a SGLT2. Then my RBC magnesium isn’t quite as high as I’d like it to be. It’s a little confusing.