#5

Thanks John! There is a long way to go until we establish an accurate dosage that make sense for a long and healthy life! Until then, we are our own guinea pigs…

#6

I’ve not got a milligram scale but I bought a 100g bag of pure melatonin and I’ve been having tip of teaspoon a few hours before bed for a couple of nights.

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#7

Thanks! Please, let us know later how your experience goes with this dosage!

#8

My view about melatonin is that it is most signficant when protecting mitochondrial DNA against damage, but that is probably also the hardest thing to measure. It has a lot of other effects as well.

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#9

Interestingly when I first started taking melatonin I thought 10mg was a high dose and I would feel sleepy the next day. I seem to be handling these higher doses quite well considering. It’s certainly more than 100mg, possibly as high as 250mg.

It has a nice feel to it as well, certainly alters perception slightly. Puts me in a bit of a dream like state. I hear some people take high doses throughout the day as well to maintain high levels for health reasons.

One time I accidentally mixed up my night time and morning supplements up and took 10mg of melatonin before work, I felt like I was mildly drunk or stoned haha.

#10

10 mg/kg was also used in another recent paper: Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits - #7 by adssx

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#11

I won’t bury the lead… my question is, if I want to see if MEL helps my bones, how long would you guess I need to take it before it might show up in a DEXA? 6 months ish?

As someone who was just yelled at by their gyn for not being on fosamax, I appreciate these posts, and the dosage recommendations for humans.

John’s trick of taking melatonin if I wake in the middle of the night works so well for me that I stopped taking it before bed, but that means I’m taking it many fewer nights because I often sleep through the night.

I’ll start taking 100mg before bed whether I need it or not.

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#12

I would think citrate may be better for bone creation.

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#13

Hi I live in Australia and would really like to try pure melatonin without fillers. Which brand do you use and how accessible is it? I saw a doctor last week who prescribed Voquily and the pharmacy compounders told me that they are no longer permitted to compound melatonin (this in Perth anyway) - that I must use the one prescribed. I looked at the fillers and no thans. Am taking NOW brand - have tried a few.

#14

I got it off Pure Bulk. I just bought it.

I also have Life Extension IR/XR which combines instant release and extended release. This is good for sustained levels of melatonin, but it’s very low dose. That was off iHerb.

Whether these get through customs is up to luck and the discretion of the customs officer who may come across it.

If you want something that is far less likely to be confiscated then you can find a domestic supplier, the websites Vitamin Grocer and Mega Vitamins have many brands available. But this isn’t pure melatonin without fillers, they’re capsules, tablets or gummies.

Mega Vitamins has better brands available like Life Extension, Now and Swanson.

I’ve never tried prescribed melatonin, but I honestly can’t be bothered working through the system to get something so cheap and readily available.

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#15

Its worth a try as I am really not keen on Voquily. I tried the Life Extension liquid version a while back (sickly sweet but it did work) the Now 3mg brand I have is rice flour. Doesnt feel right. I totally agree with you- only got prescribed because compounded seemed effective. I will look at the options you described thank you!

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#16

Life Extension IR/XR also has filler ingredients but it is the only way I could find to get the “microactive” form of melatonin which is extended release which has its own benefits, and was recommended to me by someone I respect.

Sounds like you might like the pure melatonin powder from Pure Bulk. Bulk Supplements is also an option.

You could capsule it yourself, or just use a spoon and dry scoop it like I have been. If you’ve ever eaten any weird herbal/supplement powders before it won’t be that bad. It’s slightly bitter, and the flavor lingers a bit. No big deal for me.

If you have a capsuling machine you could capsule some. If you have a milligram scale you could break one of the capsules open after filling them just to measure how much you’re getting on average per capsule if this is something you are interested in knowing. I am thinking of getting a scale soon.

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#17

Thank you Travis.

I dont like alginate (the Life extension one) as it effects the thyroid amongst other things. Funny enough I have their sleep one with nobiletin though I havent tried it because it has colourants and other fillers. Though nobiletin is hard to find so maybe I could tonight. I did find their vanilla flavoured melatonin liquid to be effective a while back. Am defintely leaning towards pure - I would probably dissolve a small amt into my pomegranate juice. Have you had any side effects? I mean did it feel different to others?

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#18

I’ve never heard of nobiletin, I’ll look into that one. Looks to be a component of citrus peels. I’m a big fan of orange peel powder, and citrus bergamot. I take these nightly. I wonder if I get nobiletin from these?

I personally just put the powder in my mouth and then down it with water. Funnily enough I downed it with some coffee a few days ago and had no lingering taste at all. I really should cut back on coffee lol!

I would recommend just putting it in your mouth, holding it there for a bit for some potential sublingual effects and then drinking it down with pomegranate juice (or whatever you want to drink it with.)

No side effects either, other than the fact that melatonin can leave you a big groggy the next day if you’re not used to it. My experience with melatonin, which I detailed in a previous comment, is that when you first start taking higher doses you can experience grogginess the next day. I used to not want to take the 10mg capsules the day before I need to wake up early for work. I’m just going to take this larger dose nightly now.

I feel no ill effects.

I’d advise slowly titrating upwards to gauge how you feel.

#19

https://dergipark.org.tr/en/download/article-file/3392275#:~:text=In%20citrus%20fruits%2C%20nobiletin%20content,different%20geographical%20regions%20may%20vary.

Nobiletin was detected at a concentration of 0.43 mg/g in dried orange peels collected from California, whereas orange peels collected from China exhibited higher levels of nobiletin at 7.79 mg/g (4).

Discovery of Nobiletin from Citrus Peel as a Potent Inhibitor of β-Amyloid Peptide Toxicity - PMC(2-(3%2C4,nobiletin%20on%20PC12%20cell%20models.

Nobiletin (2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one) is one of the major polymethoxyflavones in the peel of citrus fruits, including oranges, mandarins, limes, and lemons [10]. Various pharmacological effects attributed to nobiletin include antioxidant, anti-inflammatory, anti-diabetic, anti-atherogenic and anti-carcinogenic activities [11,12,13,14,15]. The neuroprotective property of nobiletin has been demonstrated in several recent studies. The compound prevents ischemic brain injury by regulating the Akt/cAMP-response element-binding protein (CREP)/Bcl-2 pathway in Sprague–Dawley rats. Nobiletin reduces Aβ-stimulated memory impairment in several AD animal models, including olfactory bulbectomy mice, APP-SL 7–5 Tg mice and 3XTg-AD mice [16,17,18].

There is some evidence showing that citrus peel may prevent AD.

Increasing evidence has demonstrated that amyloid-β peptide (Aβ), the hallmark of Alzheimer’s disease (AD), evokes oxidative and inflammatory cascades, which ultimately lead to the death of neurons. The purpose of the present study is to demonstrate the effect of nobiletin, a representative compound of citrus peel, in preventive and therapeutic approaches against neuronal damage by exposure to Aβ25–35. Nobiletin significantly ameliorated Aβ25–35-mediated cell death by restoring abnormal changes in intracellular oxidative stress, cell cycle, nuclear morphology, and activity of apoptotic caspase.

Where do you get your citrus peel, please?

#20

I tend to eat the whole slice of lemon/orange etc (perhaps cutting the harder part off the ends of a slice of lemon). That’s because there seems reasonably good evidence that there are helpful things in the peel as long as it is well washed.

#21

Thank you. I do that, but not the peel of the whole orange. Was referring to citrus peel powder, to mix into my tea. But I found citrus peel granules on Amazon.

#22

There’s a thread somewhere here, I think started by Alex Chen, about consuming citrus peels. FWIW, I’ve been eating mandarin and orange peels daily at breakfast for several years now. I eat a whole mandarin and half an orange (with peel). However, I only buy organic and wash thoroughly.

Multiple benefits for skin (I’m of scandinavian descent living in SoCal), and I had a small BCC removed from my back in 2011 (no recurrence since). Combined with green tea, very protective against skin cancer. Packed with carotenoids, vitamins and other polyphenols and good source of fiber. Has d-limonene and other terpenes with multiple health benefits, including against CRC.

Just a habit I got into, and a way of getting a daily dose of citrus. Can’t hurt, might help.

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#23

@Bicep highly recommends Pectasol.

#24

Thank you. Bicep and I, discussed it in another thread. It is expensive, and only provides milligram doses, compared to the peel of a whole mandarin.

Although most studies have been done on modified citrus pectin (MCP), the article below points to studies below using plain citrus pectin, apple pectin, papaya pectin, and even broccoli stalk pectin.

The added benefit of plain citrus pectin, which I just discovered now, while searching for this post, is that it actually heals ulcers (in rats). It is a folk remedy in Brazil.

The peels of fruits from Citrus aurantium L., popularly known in Brazil as orange bitter, are commonly used asatea form for the treatment of gastrointestinal tract disorders, such as ulcer and gastritis. We evaluated the healing effects of essential oil from the peels of Citrus aurantium fruits (OEC) on gastric ulcers in middle-aged rats. We examined the effects of a 14-day chronic OEC treatment on gastric mucosa in middle-aged male Wistar rats that were given acetic-acid-induced gastric lesions by morphometric and immunohistological analyses. Oral OEC treatment significantly reduced the lesion area (76%) within the gastric mucosa and significantly increased (P < .05) the height of regenerated mucosa (59%) when compared to the negative control group.

The active ingredient seems to be limonene,

The exact chemical composition of essential oil from fruit peels of Citrus aurantium was measured and already described by Moraes et al. [20] that indicated the presence of limonene (79.83%), myrcene (1.43%), and octanal (0.45%).

Mandarin peel also is high in limonene.

In the case of mandarin, the predominant compounds were limonene (51.81–69.00%), 1,8-cineole (0.01–26.43%), and γ -terpinene (2.53–14.06%).

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