Interesting, but a long way to actionable human dosage. Japanese studies of osteoporotic women and epi natto consumption surveys are all over the place.
At times studies of K2 use other than 7 isoprene residues. The most frequent alternative is 4. (ie MK4)
adssx
#84
I agree, based on studies alone, the evidence is weak. Based on my own lived experience, though, unless proven otherwise, I’ll keep using K2 MK-7 forever 
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adssx
#85
French-Chinese-German-Italian paper: Vitamin K-Trolox Synergism Realized in Hybrid Neuroprotectant with Potent Anti-Ferroptosi/Oxytosis Activity, Reduced Toxicity, and In Vivo Efficacy in Alzheimer’s Disease Mouse Model 2025
Of course, it’s a mouse model, but the methodology is interesting:
The Chou group systematically explored the structure-activity relationships (SAR) of vitamin K derivatives, identifying menaquinone-based analogs 9 and 10 with enhanced neuroprotective profiles against oxytosis (Figure 1).
Of note, vitamin K analogs confer ferroptosis resistance through a non-canonical pathway involving ferroptosis suppressor protein 1 (FSP1), operating independently of the glutathione peroxidase-4 (GPX4) axis.[17]
They used those derivatives:
According to ChatGPT: " Menaquinones are 2-methyl-3-polyisoprenyl-1,4-naphthoquinones (MK-4, MK-7, etc.). The 9 and 10 compounds have an amino at C-2 and no polyisoprenyl chain at C-3, so they’re best classified as amino-naphthoquinones / menadione (vitamin K3) analogs, not MK-type vitamers."
