Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing

[Joseph_Lavelle]

Interesting paper

Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical...

“Several supplements, including MitoQ, urolithin A, omega-3 polyunsaturated fatty acids (n3-PUFAs), and a combination of glycine and N-acetylcysteine (GlyNAC) can improve physical function in older individuals through a variety of inter-dependent mechanisms including increases in mitochondrial biogenesis and energetics, decreases in mitochondrial reactive oxygen species emission and oxidative damage, and improvements in mitochondrial quality control. “

Found this on X

[KarlT]

@Joseph_Lavelle

“Several supplements, including MitoQ, urolithin A, omega-3 polyunsaturated fatty acids (n3-PUFAs), and a combination of glycine and N-acetylcysteine (GlyNAC)

Is there good evidence from studies not funded by the manufacturer that any of these work?

[Joseph_Lavelle]

Here’s something re: omega 3s. It the only one I’ve heard about having a legit anabolic effect. Perhaps it’s only an inflammation reducer (indirect effect).

Muscle Physiology and Aging: the Anabolic Potential of Omega-3 Fatty Acids

[Chris McGlory, PhD, on the Anabolic Potential of Omega-3 Fatty Acids]

[Ray1]

I had assumed that Mayo Clinic’s glynac studies were impartial, but Mayo sells Thorne Glynac, so perhaps not.