#21

I am interested in participating in the group buy. I would like to have 5g as well.

#22

I would be interested in 2 grams also.

#23

I may also be interested in a group buy.

#24

I would also be interesting in the group buy.

#25

Interested in at least 5 g

#26

2 grams, just let me know.

#27

I am interested in the group buy.

#28

Yes of course. I might have it next month. Anyone who is interested please dm me with your contact details. I am going to make a private group with all the molecules I’m making available

1 Like
#30

That should be ok. I send you and everyone else on this thread a DM

1 Like
#31

Please add me to the group @Ryan

#32

I apologize if I missed something. Is it much cheaper with a group buy?

Is this the same “chemical” you are ordering?

If you do not want to participate in a group buy, you can buy it from Cayman Chemical. Register, which I did, and they will sell it to you. A little pricey, but most research chemical suppliers are.

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

https://www.caymanchem.com/

Registration is straightforward.

#33

I have been testing the racemic ethyl ester form for the past few days. The ethyl ester dissolves in MCT oil and is more absorbable than the the free acid form. Once absorbed the ester should undergo hydrolysis back into the free acid form by non-specific carboxylesterases.

MA-5 is basically the plant hormone Indole-3-acetic acid with the acid tail swapped with a mitochondrial targeting side chain.

The effects so far have been a noticeable increase in ATP production, more exercise stamina, and an over all better mood. Sleep as not been effected.

I like to go for morning runs and It has made sprinting easier with less fatigue.

This could be placebo or just from the extra mental clarity but it seems like I can hear the details in music a little better.

This is the racemic compound so the pure S isomer effects should be even better. The lab is testing now if their method for getting the pure s isomer was successful.

I think MA-5 will end up being a very powerful compound.

1 Like
#34

What my lab is producing is the S enantiomer which is the isomer that raises NAD levels and activates all of the SIRT1-7 proteins.

It also will be 100x cheaper than ordering from a chemical supply website. Not sure why you posted that. No one is going to pay $140 dollars for 10mg. Also you usually need to ship to a business address and be emailing from a company email to order from most of those companies.

#35

This company will ship to a private address. I have ordered from them before.

The reason I posted was because I didn’t understand that you were going to supply a superior product at 100x cheaper.

I wasn’t trying to rain on anybody’s parade.

1 Like
#36

I’d be interested. Wonder what synergies there might be with IPAM
268% Median Lifespan Increase with Indolepropionamide aka Indole-3-propionamide or IPAM – What this is, and why more studies NEED to be funded!

1 Like
#37

Hypothesizing the interaction between Mitochonic Acid 5 (MA-5) and Indolepropionamide (IPAM) involves combining what’s known (or proposed) about their individual mechanisms and imagining potential synergistic, additive, or interfering effects on mitochondrial function and cellular metabolism.

:test_tube: 1. Overview of MA-5 and IPAM

:small_blue_diamond:

Mitochonic Acid 5 (MA-5)

  • A mitochondrial-targeted small molecule.
  • Increases ATP production and mitochondrial membrane potential.
  • Interacts with mitochondrial inner membrane protein Mitofilin (IMMT).
  • Reduces ROS and stabilizes mitochondrial structure (cristae integrity).
  • Promotes mitochondrial biogenesis and function, especially under stress or in diseased states.

:small_blue_diamond:

Indolepropionamide (IPAM)

  • A potent synthetic tryptophan metabolite derivative with antioxidant and mitochondrial protective properties.
  • Crosses the blood–brain barrier.
  • Neutralizes mitochondrial ROS, maintains membrane potential, and may regulate NAD+/NADH balance.
  • Thought to stabilize mitochondrial function under oxidative stress.
  • Potential link to circadian rhythm regulation, via its indole structure (melatonin-adjacent).

:brain: 2. Hypothesized Interaction: MA-5 + IPAM

:white_check_mark:

Synergistic Potential: Dual Mitochondrial Rescue

Mechanism MA-5 IPAM Combined Effect
ATP Production ↑ via IMMT and ETC optimization Indirect via ROS protection Potential additive or synergistic increase
ROS Suppression Moderate Potent Strong cumulative antioxidant defense
Membrane Potential Stabilized Stabilized Enhanced mitochondrial polarization
Cristae Structure Stabilized Possibly preserved via ROS mitigation Improved mitochondrial architecture
NAD+/NADH Ratio Not directly modulated May support NAD+ balance Potential support of redox homeostasis
Neuroprotection Reported in MA-5 Strong in IPAM May support cognitive and neurodegenerative resilience

:warning: 3. Potential Interaction Concerns (Theoretical)

  • Metabolic Overcompensation: Co-administration may overstimulate mitochondrial activity in certain contexts (e.g., in cancers with hyperactive mitochondria).
  • ROS Signaling Suppression: Excessive ROS scavenging (from both MA-5 and IPAM) might impair redox-sensitive signaling pathways (e.g., AMPK, NRF2).
  • Unknown Pharmacokinetics: The interaction at transporters or mitochondrial uptake mechanisms (e.g., via mitofilin or VDACs) is uncharacterized.

:microscope: 4. Hypothesis Statement

Hypothesis: Mitochonic acid 5 (MA-5) and indolepropionamide (IPAM) may act synergistically to enhance mitochondrial bioenergetics and redox homeostasis. MA-5 primarily stabilizes mitochondrial structure and ATP synthesis via interaction with mitofilin, while IPAM acts as a potent ROS scavenger and redox modulator. Their combination may result in enhanced cellular resilience under metabolic or oxidative stress, with potential application in neurodegenerative and mitochondrial disorders.

:dna: 5. Potential Experimental Directions

  • In vitro co-treatment of neurons or myocytes under oxidative stress (e.g., H₂O₂ exposure).

  • Measure:

    • ATP levels
    • ROS (MitoSOX or DCFDA)
    • Mitochondrial membrane potential (JC-1 or TMRE)
    • NAD+/NADH ratio
    • Mitophagy and biogenesis markers (PGC-1α, TFAM, LC3)

  • In vivo: Murine models of Parkinson’s, Alzheimer’s, or muscular dystrophy.

Would you like help designing an experimental protocol or theoretical model around this interaction?

#38

Obviously I’d love to hear what he has to say on this as well.

Earlier he stated:

This is promising to me as I3AA has been shown to increase lifespan in some species.

“In summary, this study identifies a novel link between AhR and SIRT2 contributing to lifespan in Drosophila . Reduced ability of the microbiota to produce AhR ligands from tryptophan such as indole metabolites results in defective gut barrier function and related disruption of metabolic pathways in flies during aging. Supplementation with IAA-producing bacteria or IAA directly markedly extends lifespan via activation of AhR-mediated SIRT2 signaling and subsequent inhibition of TOR-related metabolic pathways . These findings indicate that the indole derivative IAA, serving as an endogenous AhR ligand, has the potential to be an anti-aging agent via AhR-mediated SIRT2 signaling cascade in Drosophila during aging. AhR-mediated Sirt2 signaling contributing to lifespan extension in flies may be relevant to mammals that warrant further investigation.”

The few studies I can find on MA5 look promising as well. It appears to improve sperm quality. This makes me think it would pair well with IPAM given that IPAM in rotifer lifespan study not only increased lifespan, but size and fertility.

Given they’re both tryptophan metabolites it makes sense there would be synergy.

That analysis assumes that MA5 is similar to I3AA as @Ryan says. I’ve not looked into that.

1 Like
#39

I have MS and there is some linkage with tryptophan metabolism going awry. It’s also interesting that this strikes during young adulthood. I am thus interested in all thing tryptophan metabolism and lifespan, hence my self experimentation with IPAM 3mg per day. Almost a month and still alive :blush::joy:

2 Likes
#40

Keep us updated. Are there biomarkers you can check to see if it is helping your condition?

1 Like
#41

It’s getting close to the time you thought you’d have some s isomer ready to go. If available, please put me down for 5 grams.