Bicep
#41
This is a really good one:
I was already sold on ergo, still this helps.
8 Likes
From ConsumerLab:
I’m going to try this one:
3 Likes
Bicep
#43
It makes sense that your body makes it to put out the fire after exercise. So probably you shouldn’t dose around that time. Just a guess.
I also noticed that mushrooms high in ergo are also high in glutathione.
2 Likes
That’s what I use. I think Real Mushrooms is the best brand.
2 Likes
The only problem with that one is that the dose seems too low to move the needle. Or am I missing something?
1 Like
Neo
#46
Does the human body make it? @DeStrider second quotes sentence says that it does not
Edit to correct paste:
The dosage police holding you back? Take as many as you want.
I’m just wondering about the best way to maximize the bang for the buck. I think this would be more effective.
Nutricost is half the price for double the amount (120 capsules vs 60). The Real Mushroom brand is 500 mg of oyster mushroom and Nutricost has 250 mg of oyster mushroom. So if I take 2 Nutricost, it should be the same as 1 Real Mushroom capsule. However, with Nutricost I get all the other mushrooms - Cordyceps, Shiitake, Lion’s Mane, Turkey Tail, Chaga, Maitake, White button, Reishi, and Agaricus - as a bonus and it’s still half the price.
I think I’m going with Nutricost.
1 Like
Neo
#49
Is this one the fruit or the roots?
1 Like
Bicep
#50
It doesn’t specifically say that; it says if you eat it, it’s absorbed and distributed. As you would expect.
In the video, he says blood levels in people who exercise are higher. Also in mitochondria of exercised people.
I may be making assumptions and have no previous knowledge. Are you thinking it’s stored somewhere and only released when you exercise?
1 Like
Bicep
#51
Ok, this says it cannot be made by higher animals:
https://www.sciencedirect.com/science/article/abs/pii/S008367290860271X
Thanks for pointing that out.
2 Likes
The label says it’s the fruiting body.
1 Like
One of the studies above used this source for Hericium erinaceus:
Grown and processed in California (local!)
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Neo
#54
There was also something about of it is grown on logs instead of some artifice growth bed like wheat or something, might want to check for that
Bicep
#55
Ok, the table in this article, about half way down:
https://sci-hub.se/https://doi.org/10.1016/j.foodchem.2017.04.109
says dry weight of yellow oyster is 4 grams ergo/gram dry weight. So they are getting 5 grams out of a half gram. Somehow they are extracting it, concentrating it by about double.
Maybe that will work for you. I prefer to be sure (as much as possible) to get what I want and nothing that I don’t want. When I took 30 supplements I worried about the cost but now that I’m down to 10 Ive decided I can afford to buy the best without spending more in total.
It’s less expensive from my own Fullscript store than Amazon but not 3/4th cheaper. Still, I’m satisfied with the trade off.
“For three consecutive years, Real Mushrooms has been distinguished as the “Best Mushroom Supplement Company” by ConsumerLab”
5 Likes
Perhaps a good reason to pair ergothionine with rapamycin:
Ergothioneine Protects Against UV-Induced Oxidative Stress Through the PI3K/AKT/Nrf2 Signaling Pathway
Background: Ergothioneine (EGT) is an antioxidant, which could be detected in human tissues, and human skin cells could utilize EGT and play an anti-oxidative role in keratinocytes. And in this study we are going to elucidate whether EGT could protect the skin from photoaging by Ultraviolet (UV) exposure in mice and its molecule pathway.
Methods: Histological analysis was performed for evaluating the skin structure change. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were measured with biological assay for evaluating oxidative and antioxidative ability of skin exposed to UV light. And the level of marker molecules in mouse skin were detected by hydroxyproline (Hyp) assay, immunohistochemical analysis, Western blot, and quantitative real-time PCR (qRT-PCR). The markers of skin aging and cell death were tested by cell culture and treatment, Western blot and qRT-PCR.
Results: EGT decreased the levels of inflammatory factors induced by UV exposure in mouse skin. MDA and SOD activity detection showed that EGT decreased MDA levels, increased SOD activity, and upregulated PI3K/Akt/Nrf2 signals in mouse skin exposed to UV, which further activated Nrf2 in the nucleus and enhanced the expression of Nrf2 target genes. In the cell model, we revealed that EGT could inhibit the increase in senescence-associated β-galactosidase-positive cells and p16 and γ-H2A.X positive cells induced by etoposide and activate PI3K/Akt/Nrf2 signaling. Moreover, a PI3K inhibitor blocked EGT protection against etoposide-induced cell death.
Conclusion: The study showed EGT may play an important protective role against cell damage or death through the PI3K/Akt/Nrf2 signaling pathway in skin.
2 Likes
Ergothionine is the next supplement I am adding to my stack. 
2 Likes
Bicep
#59
Is there a blood test that the public can use for Ergothionine? I should get a baseline. It rained again and I got another approx 40 lb flush. I’m doing batches and have like 10 quarts of powder. I’m going to take a massive dose and see what happens.
1 Like
Good question - I can’t seem to find one but haven’t looked too hard.
I see that there are some reference ranges that have been published, at least for some populations:
L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia
https://www.nature.com/articles/emm20014
Also, the document below provides some good information but generally ergothionine seems to be early in its research (not a lot done so far from the sounds of it).
https://www.alzdiscovery.org/cognitive-vitality/ratings/ergothioneine
Ergothioneine_UPDATE.pdf (537.1 KB)
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