#4

Thanks for sharing about Teddi. I’m glad she enjoyed life to the very end and passed on easily without lingering in suffering. That’s beautiful and what I hope for my own pets (& myself, family and friends).
I’m sorry for your loss but happy it was painless for Teddi.

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#5

Thank you! We should only be so lucky to be healthy our whole long full life AND pass in our sleep!

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#6

Zoomies = Happy Dog = Good owner. Well done!

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#7

Thank you, Joseph! She was absolutely a happy pup. We miss her terribly and suffer from losing her. But we are thankful that SHE didn’t suffer. She got one of my young adult kids through 3 years of cancer treatment and was an amazing dog!

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#8

So sorry to hear this, but it sounds like she had such a long and wonderful life with a loving family. If you don’t mind sharing, what was her sirolimus dosing regimen?

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#9

Her Sirolimus regimen: 2.5-3mg once weekly. We both took a few breaks every few months from it for a few weeks. She weighed 45lbs and took no other medicine. But in addition to her kibble, I often gave her veggies and some beans, along with flax, hemp, turmeric, black pepper and ginger. I am a WFPB vegan so often shared my food with her…And she got tons of exercise.

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#10

Zoomies! I love it! Now I know what to call them when my dog (Shih-poo) does her “zoomies” in the yard.

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#11

Awww so sorry. Very hard to lose our furry family members but what a way to live and die, doing zoomies the night before! That’s amazing. Such a lucky dog to be so loved.

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#12

drfawn, my deepest condolences. We know that when we need to say good bye to our beloved pup it is one of lifes greatest loses.
We have a 11.5 yr old Goldendoodle from, MossCreek Goldendoodles. He has been in the Dog Ageing Project and went off the rapamycin or placebo in Jan. We are certain that he was on the rapamycin and now can’t wait to finish the study to put him back on it. He definitely slowed down after stopping the meds.

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#13

Thank you, Harvey. How long was he on Rapamycin? I wonder what the best age is to start, for us and our pets.

#14

@CoachHarvey , does this mean they are still following through on the rapamycin arm of the Dog Aging Project despite the lack of funding? If so, this is wonderful news because I’ve been concerned we might not get any data from it.

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#15

I think they are still doing the TRIAD portion of the trial, but I don’t know anything about how the timeline has been impacted by the funding termination. Matt used to say they expected first results in 2026, but I’m sure thats now been pushed out: Inside TRIAD: A Closer Look a the TRIAD Cohort - Dog Aging Project

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#16

My deepest sympathies, dr fawn…I have an 11.5yr old, about whom folks say he and I are racing each other to the finish line - I dread being without him, and we’re both still in excellent shape. He has been on Rapa at approx. 3mg/wk. But I had his supply only b/c my pharmacy screwed up my first order and sent 100mg capsules, instead of the 5mg we had stipulated. I have been opening the caps and weighing out the approximate 3mg doses. But now, a vet whom I know online, Dr. Toman, who is an anti-aging promoter, has advised that the Rapa will be ineffective unless it is in "acid-resistant"capsules. I have no clue on this, nor does my pharmacy, and whether this is true for humans, or whether their “human” capsules are acid-resistant or not. The vet supplies Rapa in tablets, but right now his supply is compromised, and I have no idea if, how, or why these tablets would be acid-resistant.
I’d welcome any comments on this from the list folks. Once again, my sincere sympathy and love to you, Dr.Fawn, for your love to her - they give so much and ask so little…

ginny

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#17

Hi Ginny,

Thank you for your kind condolences. My family and I really feel an emptiness that she filled. For what it’s worth. I gave the Sirolimus in powder form to Teddi, as I shared mine with her. I am not sure about whether it needs to be in capsule form for effectiveness, but my pup sure seemed to respond positively to it. As for myself, I feel that it must make it through my GI system in powder form, since when I raise the dose too much, I get diarrhea. I wish you and your pup great health and longevity!

Cheers,

Fawn

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#18

If anything, this just shows that it’s not getting absorbed and is being excreted in your stools. There is plenty of pharmacokinetic data showing that rapamycin powder is not effectively absorbed in humans and extensive prior discussions on this topic elsewhere on the forum. You’re most likely just creating expensive poop.

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#19

Does it have to be a special type of capsule to get absorbed or resist acid breakdown?? Do vegan capsules suffice?
Thank you!

#20

It really needs to be tablets, from my understanding. I don’t think anyone has found a capsule that will do it, but I’d search the forum for the discussions on the topic. Safest bet is to use pharmaceutical tablets such as Zydus (generic sirolimus).

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#21

The problem is that the average gastric emptying time can be much longer than what the ‘acid resistant’ capsules are marketed to. So if the spec is at 1 hour, you’d want to take it on an empty stomach and drink water and do some light exercise to increase gastric emptying time.

Totally doable and makes powder usable, if it was real rapamycin without a bunch of impurities.
I wouldn’t take powder personally since I can’t verify whether it’s real.

#22

Did anyone test blood levels after taking an acid resistant capsule + water?

#23

There is a research paper on why higher doses of rapamycin cause diarrhea. And yes - some sort of good protective capsule is needed for rapamycin. Its hard to know what is working in a person, without blood tests to validate.

See this thread:

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