blsm
#392
@DrT, I’ll try to get one today. My hairline seems pretty normal for my age and I wasn’t expecting anything so there’s no up close before for comparison.
2 Likes
JuanDaw
#393
Score one for low dose doxy on DAV.
2 Likes
blsm
#394
This is the best I can do with my phone camera.
7 Likes
Do you have a before pic?
blsm
#396
No, because I wasn’t planning on that happening unfortunately. It’s just something I noticed.
blsm
#397
@DeStrider, I found a candid from a wedding on 10/28 and zoomed in on my hairline. It’s probably not a good comparison but it’s the best I’ve got.
6 Likes
SNK
#398
You keep teasing us with these nice pics of yours, will we ever see a bit more though hahaa
2 Likes
LaraPo
#399
This means that you’ve got a new growth of hair! It’s interesting. Could be DAV.
3 Likes
blsm
#400
@LaraPo, I have actually been getting lots of compliments on my hair lately.
4 Likes
blsm
#401
@SNK, I will post a picture of myself in my log toward the end of November when I’m finished with DAV and get my lab results. Keep in mind that I’ve only been on rapa for 10 months and haven’t done anything cosmetic. I’m 54 tomorrow but now I feel as good as I did at 29.
8 Likes
KFISH
#403
I wanted to report that I finished my “DAV” I had no side effects, blood test came out perfect same as usual there was no changes to any longevity blood markers. If anything, I had placebo effects of well-being, possibly will try to again in a couple of years down the road if needed for now, I will continue with Rapaymcin protocol.
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LaraPo
#404
Did any of your bloodwork markers improve? Like CRP?
KFISH
#405
CRP 0.5 always remains low-
1 Like
KFISH
#406
Quite frankly, I didn’t see anything change… Like I said, if anything, it was a placebo effect, and I felt well-being but I’m a very positive person, so I don’t put too much into it. I wasn’t really looking for anything except possibly killing senescent cells for the future. Not sure how to test besides my blood test which showed no new revelations.
3 Likes
Neo
#407
“Crapsules” - Might be something for future iterations of DAV as used in other cases where gut microbiome takes big hit:
https://twitter.com/erictopol/status/1722671524929524221?s=51&t=zJMJ1xVdRJYEDYz-DHipTw
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I’m now exactly half way through my 35 day DAV experiment. So far, absolutely no changes to report, either good or bad. My virus cleared up more quickly than I would normally expect but I really can’t put that down to the therapy because my wife subsequently caught it and had very mild symptoms too.
4 Likes
blsm
#409
I finished yesterday. I lost about 5 pounds total and didn’t change my diet. I have been more mindful of getting a little bit more calories and trying to add some liquid calories per @scta123 (thank you) and I’m no longer losing. I don’t feel weak or anything just very lean. My bmi is currently classified as mild thinness. My perception is that some subtle inflammation was/is reduced but without blood work I have no evidence. The azithromycin felt the most anti inflammatory to me personally. I had several times where old injuries I had forgotten about would become slightly painful/stiff for part of a day and then return to normal-whatever that might mean. Other than that the only thing I noticed was sprouting a few new hairs during DAV. I will definitely do it again in a year.
11 Likes
Some people just love to get a rise by spouting…ignore them.
I am a physicist with 40 years of research in human biochemistry; specifically, the ageing process. I would like to make some observations. To kfish…that second week of your experiment when you experienced flu-like symptoms. That is precisely what you should experience as a die-off reaction of cellular debri from senescent cells being cleared from your bloodstream. as far as the obvious signs of rejuvenation…remember, in the mouse dasatinib experiment, rejuvenation did not occur for 2 months or 1/12 of mouse lifespan. All things being equal (and they certainly are not) you should not expect outward signs for 6 years (it took a while to get like this…it’ll take a while to get back). Patience, my friend, it is about repair once the offenders have been killed off, and it is too soon to know. By the way this is not a license to experience intense reactions. BACK-OFF if you feel terrible, killing the patient will ruin the experiment, and there will be plenty of time to experience the pain of rejuvination later.
As a general ccomment to the brave souls in this forum…no one has ever created anything new without first being arrogant enough to believe he can do something that no one has ever done before. But there must be balance…firstly anyone can have a reaction to anything so prepare! Titrate the dose! Anything new–nibble first, then a little bit more…you will get to your experiment soon enough. With doxy, az and C, there is not much danger, but be safe, try a little first. Next, regarding Lisanti, he is without doubt one of the primere egghead researchers of our time, and though not the only one in the field of senolytics (Kirkland did dasatinib/quercetin and later Fisetin), both he and Kirkland were cancer researchers and were likely exposed to each others research as early as 2011, And Lisanti was published on Dasatinib at that time.
On to buisness. Firstly, In his many papers on Doxycycline (dx) Lisanti takes great pains to refer to dx as “already approved”, and “readily available”, and his writing is always plain-spoken, making him easily readable to a researcher like myself (and is the true mark of confident intellect). For him to be surrepticious in his description of dx dosage would be out of character. I therefore take him to mean common dx.
Secondly: throughout his research, he repeatedly refers to molarity in the blood as a measure of dosage to achieve his “rho-zero” effect on the the csc mitochondria (effectively corraling them between a rock and a hard place), before throwing in the Vitamin C bomb to wipe them out. To get a dosage of dx in mg/kg-body weight requires a conversion involving the molecular weight of dx (believe me you don’t want to go there), and then absorbability must be taken in to account. A better way is to review the old literature for dose/plasma concentration tables (difficult but dooable). I have reviewed these and they are not out of line with the dosages refered to in item (62) of his patent. Thirdly, concerning patent applications, the point is to think of every possible configuration of the effect you are trying to achieve. it is clear therefore that any one description is not meant to void any other. Therefore, the experiment as listed in item (62) stands on its own. Patents are pie-in-the-sky descriptions and are by their nature very different from research papers, and would present the opportunity for a properly published researcher to tell you what he really thinks. In fact it would not surprise me if after 35 years of research, Lisanti decided to experiment on himself, (I know I would).
It is a new world gentlemen, have at it, but be careful out there.
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Livin
#412
I think the risk is from macrolides such as azithromycin prolonging the qt interval. So if you have inherited long qt syndrome this combo is probably not for you. Maybe people should have an ekg before starting this therapy to confirm they do not have long qt syndrome. Also probably not a good idea to stack any other drugs known to prolong the qt interval.
3 Likes
