My Dementia Protocol - Please improve it and offer advice

[Jay]

This topic may have already been discussed ad infinitum and I may have missed parts of it in which case I apologize for re-hashing a settled discussion.

I understand your calculation thoroughly, but that’s assuming that there is only 5 mg lithium orotate per capsule. I do notice that the front of the Double Wood label indicates lithium orotate 5 mg, but the label on the back says to me that it is 5 mg elemental lithium (from lithium orotate) which means there’s a lot more than just 5 mg of lithium orotate in each capsule.

ChatGPT, being far from foolproof, I believe agrees with me on this. Here is a ChatGPT summary:

Feature	Double Wood	KAL
Label Claim	5 mg Lithium (from lithium orotate)	5 mg Lithium (from lithium orotate)
Type of Lithium Stated	Likely elemental lithium (but not clear)	Explicitly elemental lithium
Approx. Lithium Orotate Content	~130 mg	~130 mg
Approx. Elemental Lithium (absorbable)	~5 mg (assuming label refers to elemental Li)	5 mg (confirmed elemental lithium)
Other Ingredients	Hypromellose (capsule), rice flour	Vegetable cellulose (capsule), cellulose, organic rice extract blend, silica
Estimated Total Capsule Mass	~140–150 mg	~140–160 mg
Capsule Type	Vegan (hypromellose)	Vegan (vegetable cellulose)
Public Certificate of Analysis (COA)	Not publicly available	Not publicly available
Company Transparency	Generally reputable; COA may be provided on request	Company declined COA to a user (per Reddit)
Primary Use	Mood support, neuroprotection, microdosing	Same

[DrFraser]

I agree on further review that they are listing elemental which is interesting as the Rx Lithium Carbonate is listing the mg of the compound not of lithium. Either way, at 10 mg/day this is still <10% of the minimal therapeutic dose of elemental lithium and certainly nothing to monitor levels of.

Good catch though - but not clinically meaningful in this particular instance.

[amuser]

[John_Hemming]

Different lots different results

[59vw]

Double wood capsules are in mg of LiOrotate, not elemental Li according to the company. See my post here

Lithium Supplementation

I bought this brand on Amazon but then reading the reviews someone had written in to ask whether the capsules had 5 mg elemental Li or 5 mg LiOrotate. Turns out they are 5 mg LiOrotate which is a very small dose of elemental Li since ~ 130 mg of LiOrotate is ~ 5mg of elemental Li (0.1915 mg / capsule). Review pasted below… Blockquote M. Jury 1.0 out of 5 stars Dosage info is incorrect! Each capsule contains 0.1915 mg of elemental lithium, not 5 mg! Reviewed in the United States on February 24, 2025 Verified Purchase Here is an email reply I received from Double Wood Customer Support and following that is the email inquiry that prompter their response. The dosage info on the back of the label is incorrect, but the dosage info on the front of the label is correct. There is 5 mg of Lithium Orotate in each capsule which contains only 0.1915 mg of elemental lithium. If you want to get 5 mg of elemental lithium in a single capsule then you need to switch brands and get a 130 m…

[amuser]

I asked the company a couple days ago, and they said it contains 5mg elemental lithium.

I just replied with a pointer to the Amazon review. Will update with any follow up.

Update:

Still insisting that it’s elemental lithium, even after pointing out the Amazon comment.

The COA from the product web page says 5mg lithium orotate, and the third party test just says ‘lithium’, so seems ambigous.

Just buy something else.

[dicarlo2]

Wild that even the supplement manufacturer’s customer support is confused about elemental lithium vs lithium orotate.

[CronosTempi]

If a company cannot answer basic questions about fundamental aspects of their product, but instead engages in a bunch of waffling, it’s time to look for a different product/company.

[59vw]

If this is true at a minimum change the label to indicate 130 mg Li orotate, 5 mg elemental Li.

[CronosTempi]

Nice discussion of rapamycin (04/11/25) courtesy of Dr. Fraser.

Is RAPAMYCIN the KEY to LONGER LIFE and Better Health? (DrApoE4)

Is RAPAMYCIN the KEY to LONGER LIFE and Better Health?

[DrFraser]

Thanks - took a while to get the files and then get them formatted. Dr. Barzilai and Dr. Zazala were on that panel, and it was a pleasure to meet them.

[LaraPo]

I find the “by design” hypothesis compelling. It looks like the original ideal design is gradually eroded by cumulative damage, leading to a final outcome that may likely deviate from the designer’s intended goal. But what was the initial ideal blueprint if there was one at all? We cannot avoid damage unfortunately…

[John_Hemming]

I agree also that evolution selects for mean lifespan. This is very obvious when you look at different species. If people want I can give a link to one of my posts about this.

My own conclusion is that the aging and development clocks are the same clock. That is in my poster for BSRA again if people want the link to this again just ask.

[LaraPo]

Yes, pls post the link.

[John_Hemming]

This is the link which looks at evolution selecting for mean lifespan.

Are we programmed to die?

[desertshores]

There is always hope that if we can’t cure Alzheimer’s, at least little by little, we are reducing the per capita incidence.

Nick (PhD, Oxford; MD, Harvard) is one of my favorite YouTube MDs. His videos are a little shorter than most, and he is not always trying to sell anything or get you to upgrade to “Patreon,” ring that bell, etc.

He is personally interested in Alzheimer’s because he possesses two copies of the APOE4 gene variation.

New Data Suggests This Oil Could Help Prevent Alzheimer’s Disease

Amid all the warnings about a ‘dementia tsunami’, here are the things you...

[John_Hemming]

What oil is it? (20 chars)

[Bicep]

lysophosphotydlcholine, probably spelled wrong. Krill oil is a pretty good source.

I take phosphatydlcholine off and on and he never said whether that would help, or if he did I did’t understand it.

[desertshores]

Krill oil--------------------------------------------

[DrFraser]

So … I think the thing that seems to be clear is that individuals with ApoE4’s (especially homozygous) have real problems getting DHA into their brain (not EPA of which a small % will be converted to DHA).

If the DHA is phospholipid bound then it bypasses the defective receptor … thus an argument for NOT using standard fish oil capsules as they are stripped of their phospholipids. Krill is bound to phospholipids, but also has high risk of being rancid and actually being very hard to determine that it is rancid.

We then see a variety of DHA with phospholipids — and that makes individuals feel like they’ve solve the issue, but when one looks into almost all, they are just DHA/EPA with some mixed phospholipids, but the phospholipids are not actually bound to the DHA.

We know the fatty fish with plenty of Omega 3’s has most of the DHA phospholipid bound … so getting wild caught salmon (biggest fish I’d advise), mackerel, sardines is a good back up. Then I have my backup addition of Krill with the Naturebell product that has a fair bit in it. Amazon.com: Antarctic Krill Oil 2000mg Supplement, 240 Softgels, 3X Strength Natural Source of Omega-3s, EPA 240mg + DHA 160mg + Astaxanthin 800mcg – No Fishy Aftertaste – Mercury Free & Non-GMO : Health & Household
and I take a double dose as I’m trying to get close to 1000 mg of Omega 3’s per day between this and fish.

There are all types of fancy and expensive options out there … this is my current strategy, but it continues to evolve and next month I might change to something different.