#41

Thank you. That is very helpful!

#42

Hi Grant,
Good question about xylitol. Lots of studies reveal that xylitol provides excellent benefits on the oral microbiome. However, very little research has been conducted regarding xylitol and other polyols (alcohol sugars) on the human gut microbiome. My intuitive reply is that in moderation, xylitol would not have much of a negative impact on the gut microbiome. That said, the gut microbiome is one of the most critical regulators of human health. I encourage people to take proactive steps to create and maintain a healthy gut microbiome. Diet is the most critical factor. It is necessary to Ingest a diverse range of plant-based foods to create a healthy gut microbiome. Watch my 8-minute YouTube video titled Ross’ Salad Buzz: https://youtu.be/IwEfAW70W2I Also, Dr. Ohhira’s Probiotics, which contains over 500 postbiotic metabolites, is the best microbiome supplement to take. Here is link to a free booklet: naturalpharmacist.net/ohhirabook Healthcare professionals can open a Professional Account by calling Essential Formulas 800-430-6180.

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#43

any recommended references about trehalose and allulose for or against gut health or brain health?

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#44

I’m not familiar with either trehalose of allulose…sorry.

#45

Great list, thanks for sharing, @DrFraser; lots to look into.

For Alzheimer’s specifically, which I think is relevant if we’re targeting those with ApoE4, Berberine looks promising, at least in animal models of Alzheimer’s.

Berberine has a lot of other potential benefits outside of it’s neuroprotective effects too.

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#46

My question for you, was around the discussion on NT Factor. I know you are familiar with that product and I’d love to have your thoughts, and also where the best evidence available (e.g. research) is supporting this. I know there are a lot of articles out there, many not that compelling. I’m wondering if you can highlight the most compelling data?

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#47

DrFraser, You’ve likely already read it, but in case not I found the Dale E. Bredesen book “The End of Alzheimer’s” published in 2017 to be an interesting read about 8 years ago. I wonder if he’s updated his protocols since then? Hmmm … another area I’ll need to research!

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#48

FWIW, a test like Prodrome | ProdromeScan™ might be useful in determining if supplementing membrane lipids would be beneficial (whether NTFactor or Prodrome or BodyBio PC). Relevant test biomarkers:

Ethanolamine phospholipids
Ethanolamine plasmalogens
DHA ethanolamine phospholipids
Choline phospholipids
Choline plasmalogens
DHA choline phospholipids
Methyltransferase/choline system
Phosphatidylethanolamines
Phosphatidylcholine
Sphingomyelins
Ceramides
Phosphatidylethanolamines
Ethanolamine plasmalogens
Phosphatidylcholine
Choline plasmalogens

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#49

GlyNac
Theracurmin
Creatinine

The first two have shown benefit on limited human studies in patients with dementia,
Last has shown some indirect evidence

Also to consider:
Pentanoic acid
Lion’s mane

Scant animal evidence that these maybe helpful as well.

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#50

Grant,
NTFactor Lipids renews mitochondrial membranes and increases ATP/energy production. Send me your email addreas and I’ll forward extensive info to you. There are over 60 publications on NTFactor Lipids. I take it daily…it is one to my top life extension supplements. Ross

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#51

Hit of xenon anyone?
https://www.science.org/doi/10.1126/scitranslmed.adk3690

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#52

Maybe consider adding Carnosine, specifically for those with APOE4.

Also a more recent meta analysis:

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#53

I want to thank everyone for contributing, and hopefully we keep this topic open as a great source for adding to my protocols. Now need to go through all of this content and pick what to add.

Sorry I’ve been a bit absent - have 3 very solid 12 hr + commute days in the ER.

Naturally for all of us, neurocognitive decline is one of the worst things that can happen, and everyone, with or without ApoE4’s would tend to benefit from such an approach as all these thing also seem to extend longevity.

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#54

The older we aim to be, the more we are at risk for cognitive decline. An almost inevitable decline in funtion as we get older.

Yes, I find brain health the most important part of longevity. Living a 110-year-long life, while having the last 40 years spent lost in a severely demented state is just so sad.

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#55

I just canceled my order. Too much stuff I don’t want.

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#56

hi, can you please just explain what you mean by. * Rapamycin/Sirolimus, if ApoE4, consider q14 day dosing with goal 100 hr level of ~3 ng/mL
I am apoe4+ and take 6mg rapamycin weekly but sometimes every 2 weeks - but I dont know what you mean by “100hr level of 3 ng/Ml”

I take mounjaro also though BMI 25.5 and weight lift but the other drugs are hard to get in the UK -ezetimibe and a SGLT2 for example.

I got it from Dr Alan Green (RIP).

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#57

He means measure your blood level of Sirolimus 100 hours after taking your dose and the level should be ~ 3 ng/ml. If less take more if more take less and repeat the 100 hour measurement until it is close to 3 ng/ml.

I’m not sure why he focuses on that blood level but we have to standardize things and I think that is what Dr. Frazer is attempting to do.

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#58

The reason why, is that 3.0 ng/mL is the minimal level that has been shown to have a significant immunosuppressant effect, and the mechanism of this is mTOR inhibition. Below that level, it is not felt to have significant effect. The data on this is the basis for them making the lower limit of normal 3.0 ng/mL.

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#59

Does this mean that anything that inhibits mTOR suppresses the immune system?

#60

The immune system is a very complex, with a large variety of cytokines, t-cells etc. Rapamycin elevates some, lowers others. This is why we don’t classify it as an immine suppressant, but an immune modulator.

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