My Skunkwork begins - Rapamycin Powder

[José]

Took me over 9 week to acquire 100mg of rapamycin with purity: > 99% by HPLC.

From my posting June 13, 2022;

Intranasal Rapamycin Lessens Alzheimer-like Cognitive Decline in a Mouse Model of Down Syndrome

Open Access Compounding My compounding; 100mg of rapamycin powder 1ml of DMSO 99ml of IV saline solution at .9% Curaplex Dart Nasal Atomization Device 1mg of rapamycin up each nostril. I can hear the black in the dark room.

Syringe is an all glass with lure lock, the only “plastic” part in contact with the solution will be the Curaplex Dart Nasal Atomization Device during administration.

08/27/2022

1ml of DMSO

1ml of DMSO added to 100mg of rapamycin

[RapAdmin]

So - you’re going to be using this for nasal administration! Let us know how it goes. It would be great to do a blood/sirolimus level test after the nasal admin, to see how much is getting into your system.

[medaura]

Hi Joseph (and hi everyone ),

I’ve been lurking here for a few weeks, picking up what all you ninja biohackers are laying down and have just started my weekly dose of 6 mg. Since COVID I can’t shake my brain fog though and I don’t know that oral rapa makes it past the BBB seeing as its molecular size is > 900 g/mol and only molecules 400-600 g/mol normally make it.

I’m therefore very interested in intranasal application and somewhat of a DIY power-dabbler. But I have misgivings about using any rapa powder from any source to deliver straight into my brain.

Anything you can share about your process so far? Your supplier of the 99% pure powder? Your overall satisfaction with your DIY delivery method?

I’d be very grateful for all input as I’m headed down the same road vs intranasal delivery.

[RapAdmin]

Hi medaura, and welcome to the forums!

Be sure to review this thread Intramuscular (IM) + Intranasal (IN) Rapamycin - A new paradigm for human longevity translation

And this thread Sirolimus Powder - 3rd party analysis

[RapAdmin]

Oh - also this thread may be of interest: Rapamycin and the Issue of Getting Through the Blood Brain Barrier

[Martin]

Hi, not sure if there’s been any update on another thread on this experiment. Any side effects? Many thanks