#6

Here is the general mantra on this - basically clean living, exercise, good diet …

To improve the neutrophil-to-lymphocyte ratio (NLR), which is a marker of systemic inflammation and has prognostic value in various conditions, several strategies can be considered. Lifestyle modifications such as regular exercise, stress reduction techniques like meditation or yoga, and ensuring adequate sleep can help reduce inflammation and improve immune function. An anti-inflammatory diet rich in omega-3 fatty acids, antioxidants, and fiber, while reducing processed foods and sugar intake, can also be beneficial.

Nutritional supplements like omega-3 fatty acids, vitamin D, and probiotics may help modulate immune responses and reduce inflammation. In some cases, medications such as NSAIDs, statins, or corticosteroids might be appropriate, but these should be used cautiously due to potential side effects.

Addressing underlying conditions that contribute to an elevated NLR, such as chronic infections or inflammatory diseases, is crucial. Managing chronic conditions like diabetes or autoimmune disorders can also help. Smoking cessation and maintaining a healthy weight are additional strategies to reduce systemic inflammation.

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Bryan Johnson stops rapamycin
#7

If anyone is smoking and taking rapamycin, I’ll start rooting for the AI takeover. Anyone care to admit it?

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#8

That’s a good point. How long does it take for the lymphocytes count to come back up and by what amount?

#9

Just a three weeks break increases it by 500 for me.

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#10

Smoking and Rapamycin.

There have been people who have admitted to it before. It happens.

BTW, I have never smoked.

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#11

My experience on this is that the Neutrophil/Lymphocyte ratio decreases with Rapamycin, which is good.

Most of my patients have total WBC’s around 2.8-3.5K. I think my last was 2.9. So yes in absolute terms your lymphocyte count will go down, but in general your neutrophil count will go down much more leading to an better ratio.

Everyone is different and I have people who do the opposite of what would be predicted, but this is the overwhelming pattern.

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#12

How rapidly do WBC, neutrophil, and lymphocyte levels fluctuate? I assume the immune system leaps into action pretty quickly if you get an infection. But let’s say I get a “not sick” baseline reading today - how soon do I want to re-check? Quarterly, twice a year, annually?

#13

These can move in hours to respond to an issue. I think it is sensible when getting a CBC to get a HsCRP. If that is elevated, then there is inflammation that will drive neutrophils up, or in some cases of a viral infection lymphocytes go up. The experience with covid was we usually got a neutrophilia even though it is a viral infection.

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#14

Even though I quit rapa I love this forum - have never heard of this ratio. Thanks for all your input to various questions DrFraser.

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#15

I do all the lifestyle modifications mentioned by dr Fraser including a near-perfect diet, yet my NLR is 8 and lymphocyres abysmally low. The downhill journey probably started with extensive radiation a few years ago, but it has become even worse lately.

I have tried a number of supplements to no effect. Just started my latest effort, injecting peptide Thymosin Alpha 1

On the bright side, I have had no infection or cold or sickness for ages. All around me catch colds but not me. Could it be that the dismal numbers somehow don’t matter in my case? All my other biomarkers are fine, e.g. hsCRP 0.17, in line with my life-style. I realize this is almost certainly wishful thinking, stemming from something I read with the gist that a strong body doesn’t need a high lymphocyte count… probably bs.

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#16

This study gives average lymphocytes by age in a healthy population:

image

with no significant difference between men and women:

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image937×567 24.1 KB

other tidbits from the paper: NLR tends to go up with blood pressure, BMI, and various diseases.

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#17

NLR 8 is very high. Are you sure that you are calculating the ratio correctly?

#18

I think the main issue in terms of Rapa and NLR is that the different types of WBC have different half lives. Hence as Rapa reduces the production of new WBC it hits Neutrophils first.

You can see that in my results on this topic.

To be honest, however, although NLR is a good target for improvement, the improvement from Rapamycin is I think meaningless.

Its a bit like the reduction in MCV which generally is good, but that from inhibiting mTOR does not mean otherwise the circumstances are good.

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#19

Just checking on your use protocol for this one. It has a short shelf life once reconstituted. It’s recommenced that once reconstituted a vial should be used in 5 days or less.

I set up my vials for 3 to 4 doses in 5 days. Did a low dose run a couple months ago, had a small bump up in lymphocytes and we have just started a 1 month, higher dose (1.67mg per). One month = 4 vials, only reconstituted prior to use.

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#20

It was almost 11:1 the last time before TA1. 4300 neutrophils per micrliter, 400 lymphocytes.
Maybe that was an extreme, it used to be more around 2800 and 600.
Now 2800 and 1000. Can’t wait for my order of TA1 to arrive.

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#21

I tend to be leucopenic even when not on rapa. My last result was 980 n vs 830 l. I think my protocol soups up short transcripts and i dont take any exogenous peptides.

#22

I did 1.67 mg on three consecutive days. Can hardly get better results, but still ask do you think there is any advantage in spacing it more?

#23

In clinical use, TA-1 is often dosed every day for months but that is for immune compromised individuals.

I’d do a more conservative approach like you are doing, 3 to 4 doses a week for 4 weeks and then test.

#24

How long is the improvement expected to last? Can TA-1 be taken for a month every N months?

#25

I also don’t gave an optimal NLR and do everything positive mentioned in this topic. ChatGPT suggested low-dose naltrexone, so I started 2mg/day 2 weeks ago. This is a good article about LDN for autoimmunity;

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