#102

Liz Parrish has done the Klotho gene therapy. As well as Telomere, PGC-1α and myostatin gene therapies.

She “looks” pretty darned healthy to me from the many videos she is in. I think she is 54 or 55 now so about 10 years of data should be available from her experience.

#103

Unfortunately n of 1 doesn’t mean anything, and I bet she does as much facial / skin work as Bryan Johnson.

2 Likes
#104

And yet we are all here doing our own N=1 personal studies.

Some would argue that N=1 studies are important when attempting to move something forward, like increasing health span.

She is not doing this in a vacuum :slight_smile:

1 Like
#105

Boosting Klotho Protein Slows Aging and Enhances Health

Summary: Increasing levels of the Klotho protein can slow aging and improve health across multiple systems. Scientists showed that mice treated to produce more secreted Klotho (s-KL) had better muscle strength, bone density, cognitive function, and even lived 15–20% longer.

The treatment promoted neuron growth, reduced muscle fibrosis, and protected bones, especially in females, suggesting widespread benefits. While human applications are still being developed, the findings point to s-KL as a promising future therapy to enhance healthy aging.

Key Facts:

  • Longer Lifespan: Mice producing more Klotho lived 15–20% longer.
  • Stronger Body: Treated mice showed better muscle, bone, and cognitive health.
  • Therapy Potential: Researchers aim to develop Klotho-based treatments for aging.

Original Research: Open access.
“Long-term effects of s-KL treatment in wild-type mice: Enhancing longevity, physical well-being, and neurological resilience” by Miguel Chillón et al. Molecular Therapy

3 Likes
#106

Since the KL protective effect was needed systemically but also in the nervous system, and KL seems to not cross the blood-brain barrier, we performed both IV and ICV injections.33,34,35 In this regard, the double injection approach could be avoided in future studies using AAV serotypes with enhanced capacity to cross the blood-brain barrier following IV injection, increasing translatability to the clinic.

ICV = Brain injections.

2 Likes
#107

Sounds like fun!!

Is there a YT video I can watch so I can it it at home?

J/K :slight_smile:

1 Like
#108

A cohort study on the correlation between serum Klotho levels and all-cause mortality in American diabetic populations

Conclusions: Low levels of Klotho were found to be strongly associated with an increased risk of all-cause mortality in individuals with diabetes (Klotho levels < 829.138 pg/ml), and a nonlinear relationship was observed between these two variables. These associations were largely mediated by age.

Open Access Paper: A cohort study on the correlation between serum Klotho levels and all-cause mortality in American diabetic populations - PMC

1 Like
#109

The first-ever Klotho Conference will be held in California, in September. Among the invited speakers are Dr. Markoto Kuro-o, who first identified klotho, and the redoubtable researcher Dena Dubal.

3 Likes
#110

Interesting. Sounds slightly cultish in a Southern California Kooky way, which occasionally results in spectacular success (e.g. Jobs/Apple) :sweat_smile:. Let’s hope it’s one of those, lol.

The subject is legit, can’t hurt, might help.

#111

Yeah, maybe too much go-go and not enough go.

1 Like
#113

3 trillionths of a gram isn’t going to do anything, you have hundreds of thousands of times more than that already circulating in your bloodstream.

I can get 5 ug for $97 from Thermo Fisher, which is 1.5 million times more material. Recombinant proteins aren’t cheap but $21 for 3.5 pg is highway robbery.

2 Likes
#114

I don’t have a rebuttal to that, except to say that we don’t know more than we know.