#29

Go to the forum “home page” (by clicking on “forum” at the top of the site) and then click on “New Topic” , again in the upper right corner of the screen. Rapamycin Longevity News - Anti-aging User Group & Discussion Forum, Learn, Connect, Live Longer, Healthier.

But - its not a bad idea to search on the site to see the existing discussions on any given topic (and add your question there, if the discussion is focused on your topic of interest), just to reduce the number of times we get the same question over and over.

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#30

ohhh thank you!! got it TY!

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#31
#32

A post was merged into an existing topic: New Adverse Finding on NMN Reported in ConsumerLab

#33

Hello,
As I live in Europe, it’s difficult to obtain rapamycin. I’ve talked to several doctors; they only prescribe it for official indications (kidney transplantation and certain cancers). In the meantime, I’ve discovered another molecule that’s also very interesting: spermidine, which strongly promotes autophagy. Spermidine can be found in wheat germ,cashew nut and Cheddar cheese. That’s what I consume while waiting to find a way to obtain rapamycin.
Michel

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#34

This service works for rapamycin
.

You can search this site (rapamycin news) for more information

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#35

Help, please!
I’ve started RAPA. My functional med MD rx’d me 2 mg weekly for senescent cell treatment, along with daily NAD+ injections and once-a-month Qualia.
Everything I’ve read here on this site points to a 6 mg dose weekly.
My doc asked me for the research pointing to the 6 mg does. Can anyone point me to “solid evidence” I can send him showing 6 mg dose?

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#36

Turn your 2 mg into 6 mg by eating a grapefruit 1-4 hours before you take your Rapamycin. It will boost the effect by 3-3.5X.

That’s how I do it.

Just be careful that none of your other meds are affected by grapefruit juice.

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#37

You need the Joan Mannick human clinical trial on improved immune system.

And PEARL human clinical trial of rapamycin … did several dosing tests. 6 mg was optimal.

Hope that helps.

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#38

Yes, that helps. I’ll google this unless you have links to them?
Best, G

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#39

All the links are in this thread on dosing of rapamycin for longevity: What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity?

If you’ve not read it already, please see our Rapamycin FAQ: Rapamycin Frequently Asked Questions (FAQ)

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#40

I googled it but don’t see the results…

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#41

PEARL study results have not been revealed yet (to the best of my knowledge): PEARL Study Results (progress)

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#42

Here is the Mannick information: mTOR inhibition improves immune function in the elderly - PubMed

The full paper: https://health.uconn.edu/aging/wp-content/uploads/sites/6/2016/04/mTOR-inhibition-improves-immune-function-in-the-elderly.pdf

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Breaking: 15% Healthy Lifespan improvement via Rapamycin seen in Marmosets
#43

A post was split to a new topic: PVC’s (premature ventricular contractions or extra heart beats) and Rapamycin?

#44

Interesting - is this common practice and safe, besides possible interactions w other drugs?

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#45

Doctors don’t generally recommend it, read more here: Improve Bioavailability of Rapamycin (2)

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#46

It becomes a problem if you have other medications that interact with grapefruit. Otherwise it’s fine IMHO.

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#47

Some medications that can interact with grapefruit include:

  • Cholesterol drugs: Atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor)

  • High blood pressure drugs: Felodipine (Plendil), nifedipine (Procardia), and nisoldipine (Sular)

  • Heart arrhythmia drugs: Amiodarone (Cordarone) and disopyramide (Norpace)

  • Anti-anxiety drugs: Buspirone

  • Blood thinners: Eliquis (apixaban), Plavix (clopidogrel), and Xarelto (rivaroxaban)

  • Antidepressants: Sertraline (Zoloft)

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#48

Interesting the vascular effect of rapamycin…
A Japanese team (Ozeki et al. 2025) published a study that may help on this matter. The results were good considering that the vascular anomalies were “intractable”: “Sirolimus treatment for intractable vascular anomalies (SIVA): An open‐label, single‐arm, multicenter, prospective trial”

(…) “Patients received sirolimus tablets or granules (Rapalimus Tablet or Granules, Nobelpharma Co., Ltd., Tokyo, Japan) orally once a day, either after meals or on an empty stomach. The initial dose of oral sirolimus tablets in patients weighing ≥30 kg was 2 mg/day. The starting dose of sirolimus granules in patients ≥30 kg was 0.7 g, equivalent to 1.4 mg of sirolimus, and the initial dose in patients <30 kg was calculated based on the patient’s age and weight (Table [1]. Dose adjustments were made according to sirolimus trough concentrations measured in the second week, to achieve a target concentration of 5–15 ng/mL.”

(I have doubts about rapa intake with or without food)

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