#123

Edited my question because I see HS crp vs CRP doesn’t change the value much… I’m either 12-14 years younger… I’ll take either!

1 Like
#124

The molecule is the same. HS (High Sensitivity) refers to the test.

2 Likes
#125

This is a smallish update-
My gluten challenge took longer than I planned due to vacation limiting my access to the particular bread I was eating. I didn’t end up making it the full 14 days. Everything was seemingly going well until day 11 when my body obviously had enough! Hahaha, I’ll spare you all the details! :slight_smile:
In the past I would get dermatitis herpetiformis outbreaks/reactions within a day or two of any trace gluten exposure and in this experiment of 2 slices of bread per day it only obviously impacted my gut. I’m happy I tried though and pleased my body isn’t nearly as sensitive.
I’m continuing to eat a no added salt diet which is working out great for me personally. I do regret my years of excessive salt consumption and think it caused a lot of issues I (not any of my doctors) could never quite put my finger on starting in my teens. Here are my personal improvements:
*I stay hydrated pretty effortlessly
*No longer have dizzy spells, weakness, fatigue if I push myself too hard
*BP is in a rock solid stable range of 90-100/60-70. (Systolic goes up to 115 temporarily with exercise)
*I never have facial puffiness
*My skin no longer feels tight/dry without lotion
Here’s a screenshot of my dietary sodium to potassium ratio intake for the week.
image
I’m slightly higher than the Yanomami but it’s not bad for living in the modern world!
I’m going to try to run more labs by the end of September. I’m hopeful for continued improvements since I’m now able to tolerate a more plant based diet with some fish/shellfish. I still have some lean meat, eggs and non fat dairy about 50% of the time but it’s a far cry from the 100% carnivore diet I was eating when I joined. I’m grateful for the education I’ve received here from so many members that inspired me to be persistent in breaking away from a dietary pattern that really wasn’t working for me.

2 Likes
#126

Are those the daily figures averaged for the week or the week’s figures?

1 Like
#127

I plugged my average intake from cronometer for the last seven days into the calculator. Hopefully I’ve understood your question correctly but let me know if not please!

#128

I have some limited lipid labs for now and a recent hbA1c. Both are improved without the addition of a statin or anything for glucose management. This is just via diet and lifestyle interventions. My hbA1c in May was 5.6 for comparison but I was early in the process of transitioning off keto.
End of 2022/carnivore diet-before starting rapa:
IMG_5602
Current limited lipids and a1c
IMG_5594
IMG_5595
IMG_5596
I still might add a statin and/or something for glucose but I’m going to get more comprehensive labs and do more research. It does show for me at least that glucose and lipids are probably not being impacted by rapa.

5 Likes
#129

I’ve decided to take the plunge with Ageless for my rapamycin. I’ve been taking Biocon/Eris Rapacan since January of 2023 with good results but with the current import situation I had to figure out an alternate plan. My labs were just drawn so hopefully later this week if everything looks satisfactory the medication will be shipped.
I’ll share my labs when the results are in. I’m actually pretty excited to start having my sirolimus levels monitored and have some professional oversight.

3 Likes
#130

Here’s my meh labs from ageless. I’m going to start a statin very soon.

My ldl is still a bit too high at 72 mg/dl. I’ve been taking a 5mg dose of ezetimibe for close to six months and I believe it probably does next nothing for me tbh.

My fasting glucose was oddly high at 108 mg/dl so I’m going to recheck it myself. I’m actually having a hard time believing it’s reflective of my norm. I’ve been on dapagliflozin (5mg) for close to six months. I’ve also been eating in a surplus in an effort to put on a little weight and although I’ve succeeded that could have impacted my numbers. I was concerned about that happening. Beyond that I think I might have been coming down with a cold that I caught from my husband and didn’t know it yet on the day I got my blood drawn. I’ve read sickness can impact glucose. I also took an extended release melatonin before bed fwiw. I know that all sounds like a lot of coping! Hahaha

My eGFR is worse as well which I need to get a handle on and recheck. I had read that could happen with the flozins in the first 6 months so hopefully it normalizes.

It will be interesting to see if ageless will provide me with rapa in light of the labs. If not I got a message from one of my Indian connections at 1am that he’s resuming shipments to the US.

IMG_7369
IMG_73691290×1161 197 KB

IMG_7370
IMG_73701290×1273 184 KB

4 Likes
#131

For fun I threw your test results into CGPT5 with the prompt:

Provide an indepth analysis and summary of the attached blood test results and identify measures that are less than optimal, when considering optimal are those levels identified by Peter Attia according to his Medicine 3.0 definition. Identify strategies to get the markers that are out of the optimal range, back into the optimal range. Please identify approaches for each of the measures that need improvement.

Response:

Here’s a full Peter Attia “Medicine 3.0” style interpretation of your recent blood panel, using optimal (not just normal) targets — and specific, evidence-based actions to move each parameter toward Attia’s preferred ranges for long-term health and longevity.

:dna: Overview

Your overall profile is excellent — strong hematologic, metabolic, and lipid parameters with very low inflammation.
A few readings are borderline elevated or suboptimal from an optimization standpoint (not pathology), particularly:

Category Marker Status vs Optimal Interpretation
Erythrocyte Hematocrit 48.1% Slightly high Possible mild erythrocytosis (testosterone/altitude/dehydration)
Glucose control Fasting glucose 109 mg/dL High (prediabetic range) Suggests mild insulin resistance or late postprandial draw
Glucose control Insulin 6.1 µIU/mL Borderline optimal Great, but fasting glucose suggests occasional dysregulation
Lipids HDL 57, LDL 72, TG 59 Optimal Excellent atherogenic profile
Inflammation CRP 0.30 mg/L Excellent (low) Very low inflammation
Liver/kidney All optimal — Normal function and detox capacity
Sirolimus <0.5 ng/mL Below target range Suggests subtherapeutic trough depending on dosing strategy

:petri_dish: CBC Interpretation

Marker Your Value Optimal Range (Attia/functional) Comment & Strategy
Hematocrit 48.1% (High) 40–46% (men) Mildly elevated — common with testosterone, dehydration, or high-protein intake.
Strategies: Hydrate well, check ferritin and EPO levels, consider donating blood every 3–4 months if persistently >49%. Ensure oxygen saturation >95% (sleep apnea raises Hct).
Hemoglobin 15.4 13.5–15.5 Perfect; consistent with healthy oxygen transport.
RBC count 5.18 4.3–5.2 Upper-normal; consistent with slightly elevated Hct.
WBC 5.8 4.0–6.0 Ideal — suggests balanced immune state, no chronic inflammation.
Differential Normal — No infection, allergy, or immune imbalance indicated.
Platelets 280 180–350 Optimal.

:gear: Metabolic Panel

Marker Your Value Optimal (Attia) Comment & Strategy
Glucose (fasting) 109 mg/dL (High) 75–90 mg/dL Mildly elevated — can indicate transient insulin resistance or stress/cortisol surge.
Strategies:
• Retest fasting after 12–14 hrs, low-carb dinner prior.
• Reduce evening carbs, optimize sleep (lowers AM cortisol/glucose).
• Add 20–30 min post-meal walks.
• Consider CGM use to check glycemic variability.
• If persistent >100 mg/dL, test fasting insulin, HOMA-IR, and 2-hr OGTT.
Hemoglobin A1c 5.3% 4.8–5.2% Great; near-optimal long-term glycemia. Small improvement possible via reducing postprandial spikes.
Insulin (fasting) 6.1 µIU/mL 2–5 µIU/mL Slightly above Attia’s ideal range — consistent with fasting glucose elevation.
Strategies:
• Maintain low refined-carb diet (under 100g net/day).
• Add strength training or 24–36 hr intermittent fasting once/week.
eGFR 73 mL/min/1.73 m² >70 Healthy renal function; track trends yearly.
BUN / Creatinine 19 / 0.93 Optimal Balanced protein metabolism; nothing to adjust.
Electrolytes (Na/K/Cl/CO₂) Ideal — Excellent fluid and acid-base balance.
Liver enzymes (AST/ALT/ALP) 20 / 18 / 50 <25 / <25 / <100 Outstanding liver health; supports rapamycin safety.

:drop_of_blood: Lipid & Inflammation Panel

Marker Your Value Optimal (Medicine 3.0) Comment & Strategy
Total Cholesterol 141 mg/dL <160 Very good.
LDL-C (NIH) 72 mg/dL <70 (Attia optimal) Near-optimal. ApoB or LDL-P testing would better define risk.
HDL-C 57 mg/dL >50 Excellent.
Triglycerides 59 mg/dL <70 Excellent insulin sensitivity marker.
CRP (cardiac) 0.30 mg/L <0.5 Superb — very low systemic inflammation. Maintain through omega-3 intake, exercise, oral health.

:pill: Sirolimus (Rapamycin) Level

Marker Your Value Target Range (Longevity-use) Comment & Strategy
Sirolimus trough <0.5 ng/mL 3–6 ng/mL (ITP/longevity dosing analog) Below detection — indicates subtherapeutic exposure. If you dosed >5 days before draw, likely cleared.
Strategy: Confirm timing post-dose (24 hr = trough). If intentionally pulsed weekly, target 3–6 ng/mL at 24 hr post-dose, returning to <1 by day 5–6. Adjust dose or timing as desired.

:fire: Inflammation & Longevity Biomarkers

Marker Your Value Optimal Range Comment
CRP 0.30 <0.5 Excellent anti-inflammatory status — likely due to good metabolic control and lifestyle.
Albumin 4.6 4.2–5.0 Excellent; predictive of longevity.
Globulin 1.9 2.0–2.5 Slightly low but not concerning; maintain via adequate protein intake (≥1.6 g/kg/day).

:jigsaw: Summary of Focus Areas

Priority Marker Issue Strategy
:red_square: Fasting glucose (109) Mild insulin resistance or timing artifact Recheck fasting; lower late carbs; use CGM; improve sleep and activity timing
:orange_square: Insulin (6.1) Slightly elevated Lower glycemic load, increase resistance training, possible metformin if persistently elevated
:orange_square: Hematocrit (48.1%) Slightly high Hydrate, check ferritin/EPO, donate blood if >49%, check sleep apnea
:yellow_square: Sirolimus <0.5 ng/mL Below therapeutic target Confirm timing vs dose; adjust schedule if goal is systemic effect
:green_square: CRP, LDL, HDL, TG, A1c Optimal Maintain via exercise, sleep, micronutrients, omega-3s, and fiber (30–40g/day)

:brain: Lifestyle & Supplement Optimization

  1. Metabolic Control

    • Time-restricted eating (10–12 hr eating window).
    • Add berberine 500 mg 2×/day or acarbose 25–50 mg before carb meals.
    • Regular HIIT and resistance training 3–5×/week.
    • Target fasting glucose <90 and mean CGM <100 mg/dL.

  2. Erythrocyte Regulation

    • Donate blood every 3–4 months if hematocrit >49%.
    • Avoid dehydration and ensure good sleep quality (screen for OSA).

  3. Rapamycin Optimization

    • Measure trough 24 h post-dose.
    • Typical weekly dose (for translational equivalence): 5–10 mg oral.
    • Consider co-administration with grapefruit juice (CYP3A4 inhibition) only if experienced and monitored.

  4. Maintain Anti-Inflammatory State

    • Omega-3 index ≥8% (2–3 g/day EPA+DHA).
    • Oral health and gum care.
    • Low seed-oil, low-refined-carb diet.
3 Likes
#132

Thank you so much! I do feel a little bit better about everything and after reading the explanations it all makes perfect sense.

1 Like