No. Nicatinamide is a form of B3 that is very inexpensive. It does not cause flushing like nicotinic acid. Both are called niacin accord to the article below but I usually see nicotinic acid labeled as niacin.
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Vlasko
#82
New study finds that NMN exerts anti-atherosclerotic effects in mice fed a high-fat diet. 36% reduction of atherosclerotic plaque.
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Vlasko
#83
David Sinclair reports that NMN extends lifespan of mice, not yet published. See time index 23:55:
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NR failed the ITP, why would NMN work?
JuanDaw
#85
https://academic.oup.com/innovateage/article/7/Supplement_1/1077/7490297
Increase in median lifespan in females. No mention of maximal lifespan…
NMN treatment delayed the onset of frailty in both sexes, improved metabolic health in male mice, and increased median lifespan by 8.5% in female mice.
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Vlasko
#86
So it was published. The lack of male life extension is disappointing. Its anti-atherosclerotic effects (see above) may still make it a potential life-extending compound in men since mice are less susceptible to heart disease. And probably good for healthspan assuming it doesn’t increase cancer risk.
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It may not increase cancer development, but it may increase cancer growth. It’s generally good for all cells including cancer according to the experts.
jnorm
#88
Seems in line with the finding that NAM fails to increase lifespan in male mice, as NMN is largely degraded to NAM prior to tissue uptake.
One possible concern with NAM is that it competitively inhibits the enzyme Sirt6, overexpression of which extends lifespan in mice.
For this reason it seems that nicotinic acid/niacin might actually be a better choice than NR, NMN, or NAM. It’s been shown to increase blood NAD levels at max daily dose of 750-1000mg, much lower than the max daily dose of 3g historically used to treat lipid dysregulation.
Acutely, niacin produces smaller increases in plasma homocysteine than comparable dose of NAM.
Also, with 2 weeks supplementation in rats, (500mg/kg diet) niacin increases NAD levels in multiple tissues and blood, whereas (1000mg/kg diet) NAM only increases NAD in liver and blood.
Main side-effects with niacin is flushing and stomach irritation, but possibly these could be sidestepped with ‘flush-free’ formulations like inositol hexanicotinate.
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mccoy
#89
Have you guys watched the video from Professor Andrea Meier (SIngapore NUS)? It has a section on NMN and a human study on it, the reports seem to be reasonably good.
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“Main side-effects with niacin is flushing and stomach irritation, but possibly these could be sidestepped with ‘flush-free’ formulations like inositol hexanicotinate.”
Studies show inositol hexanicotinate results in very low plasma levels of free nicotinic acid compared to regular niacin supplements. This may explain the reduced flushing effect. So you would probably have to take high doses of inositol hexanicotinate compared to regular nicotinic acid.
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Small study, but the result of dose-dependent MNM supplementation on the walking test is nothing short of amazing. Maybe I’ll have to reconsider taking NMN. Measuring the 6-minute walking test before and after 60 days of supplementation would be easy for someone to do. It is also nice to know that you only have to take 600 mg.
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A relatively new and overlooked NAD precursor is NMNH (Dihydronicotinamide Mononucleotid).
It is much cheaper than NR or NMN because the dose required is much smaller. Unfortunately, I can’t find any studies on humans.
Dr. Oracle:
"How do Nicotinamide Riboside, NMNH (Dihydronicotinamide Mononucleotid) and Nicotinamide mononucleotide (NMN) compare in raising NAD levels?
“NMNH is superior at boosting NAD+ levels rapidly at lower doses compared to NR and NMN
NMNH increases NAD+ levels up to 19-fold in cell studies, compared to only 1.3-2.4 fold for NMN.
NMNH boosts NAD+ at doses about 10-fold lower than NR and NMN.
NMNH elevates NAD+ within 1 hour, while NR and NMN can take 24+ hours.
Dosage”
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I am not myself persuaded that extra B3 is inherently good.
Does that imply that you don’t believe in raising age-related decline of NAD levels?
I don’t know, but there is some evidence (and I don’t have it to hand) that increasing B3 (eg NR, NMN) inputs is not helpful.
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@John_Hemming Based on my vague understanding that NAD+ was important for cellular energy, and a shortage of cellular energy was a problem of aging, I have been rotating niacin and nicotinimide a few days a week. Is that not a good practice? @ConquerAging seems to think youthful NAD+ is good. Not you?
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@ConquerAging seemed to have the best results with 1 g of NMN daily if I remember correctly from the videos. Niacin caused some aging biomarkers to go in the wrong direction.
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I recall differently but only vaguely. He went away from NMN and high dose niacin. Settled on low dose niacin is my fuzzy memory. Can anyone remember clearly?
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I guess it depends on which videos you’ve watched. I may have watched older ones. The key takeaway for me was high dose niacin was not good.
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mccoy
#100
I don’t know if it has been hinted at previously, but before taking NMN, which is also pretty expensive, shouldn’t we check our NAD values? On average, NAD decreases with increasing age, but as individuals, we might be placed in the upper percentiles where NAD has not decreased so much. I don’t know what happens if NMN is administered on top of regular NAD values and also I don’t know if NAD analyses are part of an established protocol.
Also, do not let’s forget, probably already cited in previous posts, that NMN may elevate blood homocysteine, so NMN supplementation should go hand in hand with L-methyl folate supplementation.
I’m presently taking NMN but do not perceive any differences, whereas other people I know perceive big differences in terms of more energy experienced. May be that’s the difference among different NAD percentiles in the statistical distribution.
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