#21

Bard code and training data was retired ~February. The open-access Claude is generally regarded as the most eager to please, as it were.

#22

Yes my Reverse T3 is usually just above 20. I know it’s a controversial test but I think it’s useful too.

#23

I know the internet says not to treat Euthyroid Sick Syndrome or NTIS, but in my case, it was absolutely necessary to improve my symptoms. Nothing else worked besides directly taking thyroid medication that included T3 in it (NP Thyroid in my case).

#24

Replaced by Google Gemini.

#25

Subclinical hypothyroidism has been associated with living longer. Obviously hypothyroidism is not good for you but having thyroid hormones that are just a little on the low end yet not low enough to cause any negative symptoms is likely to be beneficial overall for aging. There is a very good mechanistic explanation for this. It’s simply the fact that slightly lower body temperature will slow down just a little bit, all the stochastic chemical reactions that are a strong causal factor in aging.

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#26

Your point is what started me in this thread a few days ago @Olafurpall. My vague recollection of supporting evidence stuck with me but I cannot locate it. Additionally, my grandmother lived a full life to just short of 100 years with lifelong low basil metabolism, at least as an adult. She preferred not to take synthetic T4 or dessicated thyroid – said they made her feel bad.

Do you recall any references to empirical data? This seems like a fruitful line of inquiry even though the preponderance of evidence seems to run the other way at present.

#27

Here are some references:

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#28
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#29

I’ve always been perplexed by the lack of slow release replacement hormone formulations, given the ubiquity of slow release psychiatric drugs. It doesn’t seem like we’re lacking the slow release technology. In particular, hydrocortisone (dosed at least 3 times a day for Addison/adrenal issues) and thyroid, but probably others too.

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#30

It’s really unfortunate. Piggybacking off what you said, slow release T3 is impossible to find on the “online pharmacies” as far as I’m aware and most physicians won’t prescribe it.

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#31

Hey, here’s a random thought that might not hold any water…

I thought of it only because I just ordered delayed release capsules for my cats in order to give them rapa :slight_smile:

I realize DR is not SR, but can we procure SR capsules and then put a cytomel inside of one? Or, am I a lunatic and the SR has nothign to do with the actual capsule?

EDIT:
I thought through how that might work and don’t see that it could be a thing.

#32

Large new study involving 1.26 million people

Treatment of Hypothyroidism that Contains Liothyronine (T3) is Associated with Reduced Risk of Dementia and Mortality

https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgaf367/8170024?login=false&fbclid=IwQ0xDSwLGwnBleHRuA2FlbQIxMQABHoKQndZ-nTSldnW9juyWY8ZuV1Vx-OotMZylqQ4xajPZhRjTIF5rcRNTVXFN_aem_a3CUSf2yVgik3weHaov6ww

I hope this sets in motion a shift in the medical guidelines. I think it’s really unfortunate that doctors are trained to only prescribe T4 (levothyroxine/synthroid) in all hypothyroid patients.

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#33

I just thought I would mention two things in this comment, one about milk thistle / silymarin, and the other about cancer:

Concerning milk thistle, I saw this paper a while back:

Basically, silymarin seems to block one of the T3 transporters in cells. I personally take milk thistle on and off and don’t notice any problems. But it’s something to be aware of (I noticed Dave Pascoe, the longevity enthusiast, includes it in his supplement list; and he may not be aware of this issue.)

The other thing I wanted to point out that I found interesting is that virtually everyone over the age of 65 (I still have another decade+ till I’m there) gets little thyroid nodules, less than 1 cm in size. They’re like micocarcinomas. I guess the immune system takes care of them, usually, which is a reason to keep the immune system functioning optimally:

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#34

For years, I was having issues with sub optimal Free T3, despite a very strong looking TSH and Free T4. My Free T3 was typically in the 2.6-2.9 range and I was symptomatic.

I don’t know if there is any relationship here or not, but I have had zero thyroid symptoms for the past 8-9 months and it coincided around the time I began taking Retatrutide. I recently had thyroid labs and my Free T3 was 3.3, which is the highest I have seen in years when not supplementing with any thyroid medication.

Can I say for sure that retatrutide solved my poor thyroid conversion problem and raised my active T3 thyroid hormone levels? No. However, I think it’s important to share this information in case somebody sees it and can share a similar (or different) experience.

I’m at the point where I am afraid to come off retatrutide, enough that I snuck it on many airplanes while traveling all over USA and Europe (it successfully passed through security every time with no problems, FYI).

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#35

How were you ever able to get off it? I have severe symptoms - life and death type - if I miss a dose

#36

I was having symptoms while taking it and whenever I checked my thyroid levels, they’d be no better than when I was off. So I just stopped and magically improved eventually.

I wouldn’t recommend this. I have a normal TSH so I knew I wouldn’t be any worse if I stopped.

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