#182

Sunscreen users were right all along.

1 Like
#183

Well this is c elegans only to be clear.

1 Like
#184

Salicin, a component of white willow bark, produced no significant results.

IMG_1293
IMG_12931179×1357 107 KB

Clarifying that study that saw a 4x max lifespan increase in yeast with white willow bark extract

10 Likes
#185

Wow! Id been taking sulforaphane now and then but didn’t think it really had a lifespan effect.

2 Likes
#186

I saw this quote and was wondering where we are in testing things in these 3 classes. Sinxe berberine and sulforaphane are some of our best so far! However ecgc from tea was not so theyre not all winners. Has angone tested a terpenoid like beta carotene? I saw thats on the list.

“Polyphenols are one of the most common classes of bioactive compounds found in plants, along with alkaloids (e.g., berberine), organosulfur compounds (e.g., sulforaphane), and terpenoids (e.g., beta carotene”

potential organosulfurs to test:
Allacin - didnt see
Diallyl trisulfideis
ALA - i saw available
lipoic acid - i saw available
glutathione
Methionine - both had alternatives im not sure are same?

1 Like
#187

+20% lifespan increase with lithium chloride “medium” dose: Lithium Supplementation - #226 by adssx

8 Likes
#188

I think the Examine page does a great job presenting the evidence for lithium

2 Likes
#189

I sponsored Trametinib

#191

Ora Biomedical MMC Leaderboard

2 Likes
#192

I sponsored berberine plus sulforaphane.

7 Likes
#193

Sponsored dl lipoic acid and sn-Glycero-3-phosphocholine separately

4 Likes
#194

I wonder if ora can use this for extra data on aging performance? Probably too expensive. Or we can look for supplements that target this pathway?

1 Like
#195

Sponsored:

  • Ezetimibe 100 µM
  • Fluoxetine 50 µM
  • Fluoxetine 0.2 µM
  • Caffeine 5 mM
  • Sulforafane 100 µM
  • Sitagliptin 2 µM
  • Selegiline (L-deprenyl) 10 µM
  • Selegiline (L-deprenyl) 100 µM
  • Sildenafl citrate 50 µM
  • GlyNAC (Glycine 8 mM + N-acetyl-L-cysteine 3.7 mM)
  • Sertraline TBD
  • Rilmenidine 200 μM
19 Likes
#196

Thank you for doing this, much appreciated

1 Like
#197

Due to the major differences between worms and humans, my takeaway from these results is I am disregarding them if they fail, but paying more attention if they succeed.

1 Like
#198

The difficulty is that these worms dont really have senescent cells.

#199

On the topic of sulforaphane, I used to take it when Rhonda Patrick really started getting excited over it. Avmacol and BROQ were the two tested brands (both very expensive) with both components of sulforaphane. So if you see a supplement called sulforaphane “glucosinolate”, don’t buy it or you’re wasting your money.

Jarrow Broccomax seems to be the right form but it hasn’t been tested to my knowledge. It is also suspiciously cheaper.

1 Like
#200

Im excited to see high dose sulforaphane although i think it wont dissolve fully. I expect one of my combos will beat just higher dose.
Glynac also interesting.

#201

I just realized even sulforaphane hasnt approached the secret orb chemical with 71% improvement, so it should be relatively easy to find combos that do similar amounts.

#202

One paper found more life extension with 100 vs 50, that’s why I wanted to reproduce it.

1 Like