#265

Sponsored Omaveloxolone (RTA-408) - It is also NRf2 like sulforaphane hopefully

#266

I would not expect HDAC inhibitors such as ECGC to do that well in C Elegans

1 Like
#267

I’m in touch with them regularly. They’ll update the leaderboard in a few days/weeks.

3 Likes
#268

How do we convert worm doses (µM) to mouse (ppm) or human (mg/kg)?

1 Like
#269

Sponsored more nrf2 stuff. Bardoxolone was already sponsored, but I
Sponsored Oltipraz and Sponsored Bardoxolone methyl
It appears no one has sponsored Spermidine? That is surprising…

2 Likes
#270

Spermidine has had very “mixed” results already in mice, so going back and testing it in nematodes doesn’t seem to make a ton of sense to me.

See: Spermidine Impacts Health and Longevity

e: Spermidine delays aging in humans

3 Likes
#271

Vanilla ice cream anyone :yum:

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6 Likes
#272

Just because regular spermidine isn’t absorbed in mice doesn’t mean you couldn’t use a lipomosal or other version. It seems like perhaps it is converted to spermine by the gut which has some beneficial effects even though no spermidine makes it into the blood/cells. There are two version of spermine which are in Ora library. Also, it looks like someone actually is testing one of the spermidine variants now…

@EverVital the funny thing is that is the artificial vanilla that people generally say would not be as good for you as the “real” thing :slight_smile:. Although natural vanillin is in vanilla the synthetic version is generally not derived from the plant it seems

2 Likes
#273

sponsored Melatonin and Betaine (TMG) and alpha-tocopherol (vitamin E).
FYI, I saw a paper that sulforphane + vit E was very effective antioxidant in C. Elegans. If it does well it’s worth trying that combo Thieme E-Journals - Experimental and Clinical Endocrinology & Diabetes / Abstract

#274

Nice try. I think even if vanillin is good, all the other stuff in vanilla ice cream would send it the other way.

#275
2 Likes
#276

Wow, so curcumin actually turns into vanillin?

#277

I thought you might be a fan of melatonin getting tested :wink: but you also wont alter your stack anyway no doubt.

#278

I am continually making changes to my stack and testing. The test results and hypotheses drive the changes.

1 Like
#279

I’m trying to see which pathway does Vanilla affect because I don’t need another NRF2 activator, but surprise surprise, it touches everything!!

What an amazing molecule:
https://www.sciencedirect.com/science/article/pii/S2772417422000279

4 Likes
#280

Hear me out:

Lifespan Extending Vanilla Ice Cream
Ingredients

  • 1 gallon BB12 yogurt (smuggled from Japan)
  • 100g glycine (for sweetness)
  • Vanillin (enough to achieve 50µM concentration)
  • Vanilla bean, powdered (for show)

Directions

  • Mix all ingredients slowly so as not to stress out the BB12 culture
  • Follow Yogurtland process to freeze into frozen yogurt

Servings: 6, or 1 if you’re breaking a long fast

Goes well with: other palid foods, like skinless sardines in EVOO, or microwaved shitake mushroom; or if you’re @Agetron, goes well with steak and potatoes, like any other food.

8 Likes
Vanillin - Best Tasting Lifespan Extender?
#281

Good recipe for blueprint ice cream

1 Like
#282

Synthetic or natural vanilla, which one did they use in the study?

#283

From what I see, they use Vanillin, the synthetic product.

1 Like
#284

Natural vanilla is a lot more expensive