It is likely that it will appear as available because there are several concentrations to test, but it is not explicitly listed anywhere,
liked this project, but these inaccuracies make me hesitate to pay for a test again
2 Likes
My understanding is that if P>0.05 the test is not statistically significant at the 95% confidence level.
adssx
#43
Yes p=0.08 is very close to significance. Especially with this small sample size.
1 Like
Josh
#44
Did they get bafk to you why its still on list? Mine is too, but i thought maybe it would be marked once test started. But it says daily. Maybe they have automated system thats broken
adssx
#45
I emailed them abd they fixed it. I think it’s a manual process…
Which email do you use to contact them? They haven’t responded to mine.
1 Like
adssx
#48
I sponsored curcumin. Surprisingly, curcumin shortens average lifespan in worms. Hmmm.
6 Likes
Bicep
#50
Nice try! I really wanted to do a triple, but expensive and it’s worms. I just didn’t get there.
1 Like
adssx
#51
All my sponsored compounds failed:
Empagliflozin:
Dapagliflozin:
Canagliflozin:
(poke @Neo)
Telmisartan: perfectly neutral
Ezetimibe:
10 Likes
AnUser
#52
Just a note that your control worms lived longer than berberine or its control, does that mean anything?
1 Like
adssx
#53
How do you see that? We don’t have the median lifespan for berberine or its control, do we?
Cana failed in worms but succeeded in mice. A dose thing or a species thing? This just shows how uncertain (or at least wildly complicated) all of this is. It’s no wonder kaeberlein is so conservative. I’ve decided to never ingest anything only for longevity purposes.
Good reasons
- fix a measured deficiency (vit D, b12, omega3, etc)
- solve a physiological problem (high apoB, high HbA1c, inflammation, fatigue, low HRV, etc)
- feel better/stronger when I take it (placebo is good enough)
What am I missing?
6 Likes
AnUser
#55
I don’t know, I was looking at the survival curve posted earlier for berberine and compared:
https://mmabrasil.localizer.co/t/ora-biomedical-launches-crowdfunding-of-million-molecule-challenge/10093/98?u=anuser
I don’t know the methodology they use or anything nor if this matters.
It seems they vary in lifespan for control etc very much between interventions, but I don’t know what that means. It probably doesn’t mean anything.
What would be useful is to see a list of molecules where there is a difference between species. We may see then a logical pattern.
To me the priorities not on your list are:
a) Increasing gene expression for longer genes
b) Increasing mitochondrial efficiency
3 Likes
Good idea.
What symptoms would show up from:
- Long gene expression issues? Bone health? Grey hair?
- Mitochondria efficiency? Brain fog? Muscle weakness? Inflammation?
I am definitely chasing mitochondrial dysfunction in my daily behaviors to solve symptoms I face right now. MB and glutathione substrates come to mind.
I do use the citrate forms of mineral supplements I consume for calcium, potassium, magnesium based on your recommendations. (Sodium is out due to edema). But I’m primarily targeting the mineral deficiency.
1 Like
Of course Rapamycin worked on worms, flies, yeast, mice, and dogs… Every time. (Almost - don’t give it to diabetic mice).
As Dr. Kaeberlein says, Rapamycin is the only real longevity drug out there.
2 Likes
The long gene issues are basically behind quite a few of the diseases of aging.
3 Likes
Nematodes don’t have kidneys I guess.
People can have nematodes in their kidneys though, which is not good for sure.
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