#121

What are the odds, some random 2 billion year old rock I mentioned for fun?

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#123

Yeah, I knew about c-60 and couldn’t find it on the list either. I’m surprised they didn’t have it on there. Sarah Westall sells it on her program all the time. Supposed to cure all kinds of stuff. LOL.

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#124
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#125

Yes, it is a little pricey even if you make your own.

Frome SES Research:

"SINGLE BOTTLE ESS60 AVOCADO OIL

ESS60 - Carbon 60, 99.99% in Avocado Oil Extra Virgin, Organic, 120ml" $79.95"

From “https://www.sesres.com/carbon-60-supplements/c60-in-avocado-oil/”

I agree with @Bicept, that avocado oil is your best bet to avoid digestive tract problems.

I tried C60 in olive oil several years ago but felt no subjective benefits, I didn’t notice any effect on my blood work so I didn’t continue taking it.

I’m sorry but there is little proof that this does anything in humans.

FWIW: Here are two YouTube videos showing step-by-step how to make your own C60 Olive Oil.

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“https://www.youtube.com/watch?app=desktop&v=7x23GTXl488”

“https://www.youtube.com/watch?v=W_2_Zs5siN8”

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#126

Interesting to see that Curcurma, Apigenin and Pterostilbene quite significantly reduced lifespan, with these worms at least.

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#127

I didn’t see the dosing. Give that these are all HDAC inhibitors (which IMO are harmful in high doses, but beneficial in small doses see Queen Bees/Royal Jelly and beta Hydroxybutyrate during keto) it worries me if the worms respond badly to HDACi whilst other species respond well to that.

HDACi can cause apoptosis through ATP depletion in large quantities and would cause ATP shortage if not high enough to kill.

I suppose it comes down to a dosage level really.

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#128

I agree John. I think they should test at 3 levels for everything. Otherwise you’re just shooting blind. The dosage is very important.

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#129

Are people allowed to choose the dosage, or what’s going on?

#130

I answered this a few posts above. You are free to email them to setup a custom experiment however.

#131

Just remember that things that are bad for worms are not necessarily bad for mammals. Likewise things that are good for worms may or may not be good for mammals.

This experiment is to identify things that are good for worms and then try them out on mammals to see if they work.

This process isn’t perfect.

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#132

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#133

Leaderboard updated: nilvadipine to the top! Wow dihydropyridine calcium channel blockers are really great: 3 in the top :muscle: (poke @Neo @DrFraser).

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#134

It appears one of mine was tested and one i think the did a different chemical than i asked for. I hope they have good procedure to make sure they are testing the chemical they say they are at least
Edit: i havent gotten any emails back so it may be someone with a similar name.

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#135

My results arrived and they all failed: atorvastatin, bimatoprost, flecainide acetate, hydrochlorothiazide, indapamide, isradipine (Dynacirc), lithium carbonate, lithium citrate, naphazoline HCl, sitagliptin, and terazosin HCl.

I’m waiting for the results of the other compounds I sponsored:

  • Semaglutide
  • Selegiline
  • Obicetrapib
  • Urolithin A
  • Telmisartan + Amlodipine Besylate
  • Amlodipine Besylate
  • Lercanidipine
  • Lacidipine
  • Felodipine
  • Nitrendipine
  • Carvedilol
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#136

Thanks for sponsoring these. It’s a bummer that so many are failing though.

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#137

Because worm somatic cells don’t divide you should not get the differentiation problems that arise in mammals. Hence only interventions that target mitochondrial efficiency are likely to get results.

My own view is that senescence is a much bigger issue of longer lived animals as they have often worked out mechanisms to maintain function of mitochondria for longer periods.

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#138

I thought lithium was pretty robust in extending worm lifespan. How do you explain the null findings in light of previous work?

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#139

I thought lithium was pretty robust in extending worm lifespan. How do you explain the null findings in light of previous work?

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#140

Which papers found a lifespan increase in worms with lithium? How big was the increase? What was the confidence interval? Which form of lithium and which concentration did they use?

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#141

To be honest, I had stashed that information in my mind but not the sources. Some references to get started are:

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