Outlive - Peter Attia

[Jonas]

This is a podcast by Peter Attia talking about good vs. bad science, I listened once and will listen to it again. I will buy his next book without hesitation

. #269 - Good vs. bad science: how to read and understand scientific studies - Peter Attia

269 - Good vs. bad science: how to read and understand scientific studies

[Neo]

@Jonas

will buy his next book without hesitation

Is there another one in the works?

[Jonas]

No, it is just an expression. I doubt he will write another book any time soon. Business is too good. And deservedly so.

[Jonas]

@arugula

He’s 55 and no jowls yet.

do we know what stacks Luigi Fontana on? Rapamycin? Did anyone read his book? Takeaway?
Good to know he is a rapamycin researcher and 12 years ahead

: Intermittent supplementation with rapamycin as a dietary restriction mimetic - PMC

[arugula]

You can ask him. He’s on Instagram. I predict that he will say something along the lines of “not necessary if you are CR’d on a good diet” and “we don’t know the appropriate doses to avoid adverse effects yet.”

Here he says he takes only vitamin D in winter.
I'm a longevity expert. Here are my 7 habits to live longer.

[Olafurpall]

Sure, without muscle mass, people will become frail eventually. However, that doesn’t automatically mean high protein is good for that. In the short term, high protein certainly helps with muscle growth, but over the long term it can be harmful and have the opposite effect. Note that calorie restricted animals have lower muscle mass in young adulthood but then they catch up later in life because the low calorie/low protein diet helps maintain healthy muscles and prevent sarcopenia. Overstimulation of mTOR throughout life probably leads to damage and desensitization to anabolic stimuli later in life. If you want to have more muscle mass now or in the next decade or two, then eating higher protein is almost definitely going to help. However, if you’re wanting to preserve muscle mass several decades from now when sarcopenia starts kicking in, then high protein early in life might actually be worse.

[AnUser]

I actually realized that my thinking was a bit faulty, as it’s muscle strength that’s important against frailty and not muscle mass per say. It opens a pandora’s box about what keeps strength intact except muscle mass. That can be neurological things as well, I wonder why chronologically older people tend to move slowly or slower as well. There’s a lot of olympic athletes participating in low weight classes with enormous strength and relatively little muscle mass. So it’s possible. Might just be neurological adaptations weakening over time, along with the exponential decrease in muscle mass over time, and a reduction in for example dopamine.

[Agetron]

On rapamycin…I find my muscles are shredded… smaller… but also significantly stronger. Can do higher muscle resistance training weights on less muscle size.

Can out arm wrestle younger dudes whose arms are twice my size… lol.

[Olafurpall]

Here is a previous post I posted that is relevant to the discussion of protein intake and muscle mass. It shows how excessive mTOR activation, although stimulating protein synthesis and muscle mass gains in the short term, can have the opposite effects in the long term.

The effect of rapamycin on muscle growth and strength

Although it’s well known that mTORC1 activation stimulates protein synthesis and is necessary for muscle growth, too much mTORC1 for too long may have opposite effects. The study below shows that mutant mice with chronically activated mTORC1 have skeletal muscle atrophy and reduced muscle strength. Administration of rapamycin to such mutant mice in old age results in increased autophagy and partial reversal of the skeletal muscle atrophy and strength, as seen in the following study: Older animals may also suffer from chronically elevated mTORC1 similar to the mutant mice, although to a smaller extent. When atrophy due to muscle disuse is induced in old rats, they were found to have limited recovery of muscle mass in response to reuse, despite having higher myofibrillar protein synthesis than young adult rats. They also had higher rates of protein degradation. The authors speculated that the higher rate of protein synthesis in the older rats contributed to increased rates of protein…

[Jonas]

@arugula

I disagree with Fontana on his sun exposure ideals (

does he does not use sun screen or?

[arugula]

He wants his vitamin D from skin exposure.

A few more years in Sydney where the UV index reaches 13 might change his mind.

[desertshores]

FWIW: I am 82, and years of observation of people I know, tells me that sun exposure is the most damaging, aging thing you can do to your skin, followed by drug abuse and smoking.

[Olafurpall]

I second that. People usually guess I’m a lot younger than I am. While there are a lot of reason for that, I think deliberate sun avoidance and sunscreen use in the past 20 years of my life is a major one.

[jakexb]

I am 100% on the sunscreen train, especially for the face. I get moderate amounts of sun on the rest of my body, but not excessive. If I’m going to be out for a long time in heavy UV I will use sunscreen for my body also.

This is really for a few reasons:

1. Your face is one of the most exposed parts of the body and is a very big location for skin cancer.
2. UV exposure is the number one aging factor for skin. Not just from direct damage but the aged phenotype will contribute aged signaling to the surrounding tissues.
3. It’s not just vanity, but a big contributor to how old you feel is how other people treat you. You might have an epigenetic age of 20 years younger, but if everyone treats you as 20 years older, you’re going to find your self-image (and subsequently, how healthy you feel) pulled in two different directions. Looking less affected by age is a ingredient in the whole longevity picture.

[arugula]

True. Also I don’t want to be shown the door at a certain age in the workplace. I feel that if I present as a youthful person I will stay at work longer.

But vanity is a big part of it, too, for me. I think a huge part of enjoying my 60s will stem from not looking it.

I also believe strongly in the mind-body connection. If you look in the mirror and see a relatively youthful 40-year old instead of a decrepit 60-year old, that’s powerfully rejuvenating all over!

[arugula]

Regarding epidemiology, granted it’s losing value in the days where anyone can go to the grocery store and be confronted with 87 varieties of Cheez-its which are BOGO free, or McDonald’s and KFC on every block and so on.

People lie on their food frequency questionnaires, too.

But in the pre-WWII days this wasn’t an issue, people didn’t have nearly as much opportunity to eat garbage (if any), and epidemiology from back then probably retains some meaning.

[jakexb]

Nutrition studies are so so hard to get good data from. People are really terrible at reporting or even realizing what they’re eating. People think they’re eating at a deficit and go looking for wackier more exotic explanations for why they’re gaining weight, but every single study that has been done in a metabolic ward where 100% of food is monitored and measured, it always works out to calories in / calories out.

[Christoph]

New “thedrive” Podcast is out (25.9. #272) about Rapamycin with guests Sabatini and Kaeberlein

#272 ‒ Rapamicina: potenciais benefícios de longevidade, aumento de popularidade,...

[ReppinMycin]

A review that came out by the channel Plant Chompers. For context: A channel that reviews nutrition and longevity books and is in favour of plant based nutrition and Mediterranean style diets.

Peter Attia's Longevity Book Outlive: The BEST or WORST longevity book?

[Joseph_Lavelle]

@ReppinMycin That was a useful video. Thanks for posting it!