#1

Hello,

Im new here and new to rapamycin. I just took my first weekly dose of rapamycin that I received through agelessrx on Wednesday. Yesterday at work my one colleague I was in immediate contact with was sick as a dog. I always wear a 3M aura at work, and I generally avoided him when I could but whatever he had I was obviously exposed to. I have Paxlovid here ready to use if needed, and I was wondering if it’d be safe to start the 5 day pax course since I’ve only taken one dose. Then would restart rapamycin after.

I’ve done some research on interactions with pax/rapa and from what I can tell it’s not good to take them at the same time. Daily users of rapamycin would have more of an issue with this it seems. The half life of rapamycin in humans seems to be around 2 days, so was wondering what you all think.

Im taking rapamycin for long Covid symptoms and I have the pax on hand in case of exposure and since our immune systems as LC patients seem to be out of whack.

Thanks for reading.

#2

I don’t know much about Paxlovid, but perhaps you’ll find some value from these past discussions related to vaccinations:

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#3

Speaking as a doc taking care of many LC patients, one dose of rapa should not be a concern. BUT why would you start Paxlo based on a masked exposure to a person with an unknown illness and you are not sick and have no symptoms and not tested. Paxlo is a great drug but not benign.

#4

Good question. I understand it’s not completely benign. But as someone dealing with LC for years I have to constantly consider alternative therapies and their risks. I’m going mostly off the fact that there is some evidence for pax alleviating some long COVID symptoms, and I have access to pax and as someone who gets really sick and takes a long time to recover when infected with Covid or any other bug, it seemed like not a bad idea.

I woke the next day after posting this not feeling great, so I started pax. Maybe a little tired and have the metallic taste on back of tongue but feeling good so far.

#5

I totally understand where you are coming from. And yes there is evidence that some LC pts will improve with Paxlo but that is different from taking it based on exposure. Don’t get me wrong, I think it’s fine for you to take it given possible benefit outweighs risk IF infected. But maybe you should consider an actual trial of treatment with paxlo for your LC, ie 10-15d.