Completely agree about ME/CFS. It absolutely destroys your life.

I was unable to get a prescription for higher than 15mg compounded, so out of desperation, I have gone the GFJ route. So if we assume 15mg compounded = 5mg bioavail formulation, and then use GFJ (ruby red) theoretically it will get me back up to 15mg bioavail equiv, maybe higher. This is super speculative, and I will certainly start tracking my blood levels going forward, I think next month.

I will say I feel great at this dose. Everything feels back to normal.

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Do you feel great at 15 mg compounded and GFJ ? Why do you use compounded Rapa ? I use Rapamune solution from Pfizer which is pure Rapa (1mg/ml) and get peak values of > 60 ng/l with 14 mg without GF, but no relief from ME/CFS. Following your 45/35 mg indication I have now gone to 25 mg, but not yet measured pik values. I am curious to see you peak values at a dosing which makes you feel well. Blood pik value is best measured at 2.5 hrs after intake. Let me know and good luck.

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Why nobody uses the standard Rapamune solution from Pfizer (1ng/ml) ? Isnt it available in US ?
It s pure Rapa and excellent bioavailability. At 14 mg dosing I got >60 ng/l pik, see my above post.

Yes, I feel great at 15mg compounded and GFJ. The reason I got compounded is they (agelessRx) told me the 15mg compounded was equivalent to 12mg regular prescription, (and yet it was the price of a 5mg regular prescription.) Also, I used some of it for toothpaste, etc. Anyway, if its actually equivalent to 5mg, the cost argument no longer applies.

How severe is your CFS/ME?
is it post-infection? is it slow onset or fast? Do you also have an autoimmune disease? Have you ever been on a large dose of a corticosteroid while you’ve had CFS/ME?

It’s more expensive than Indian generics.

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